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KCND3: Function, Clinical significance & Overview

Potassium voltage-gated channel subfamily D member 3 also known as Kv4.3 is a protein that in humans is encoded by the KCND3 gene. It contributes to the cardiac transient outward potassium current (Ito1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.

Language: English [EN]
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KCND3 topic overview

The analysis highlights Function, Clinical significance and Overview as prominent areas in the source structure around KCND3.

Related topics
9
Source areas
3
Connected nodes
12
Extracted relationships
96
Concept neighborhoods
8
Bridge connections
12

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 5 topics
Clinical significance · 2 topics
Function · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
KCND3, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22, BRGDA9, potassium voltage-gated channel subfamily D member 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1S1G, 2NZ0
Band
1p13.2 · 3|3 F2.2
Bgee
cerebellar vermis · pars reticulata · lateral nuclear group of thalamus · pars compacta · paraflocculus of cerebellum
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 3 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How KCND3 connects Entity context

The extracted context around KCND3 shows recurring relationship patterns in the source. For example, KCND3 → A-type (transient outward) potassium channel activity, cardiac conduction, cell projection, dendrite, GABA-ergic synapse, integral component of membrane, integral component of postsynaptic specialization membrane, ion channel activity, ion transport, membrane, membrane repolarization, membrane repolarization during cardiac muscle cell action potential, membrane repolarization during ventricular cardiac muscle cell action potential, metal ion binding, plasma membrane, potassium channel activity, potassium ion export across plasma membrane, potassium ion transmembrane transport, potassium ion transport, protein binding Another extracted example is KCND3 → anterior amygdaloid area, Brodmann area 23, caput epididymis, cerebellar vermis, habenula, lateral geniculate nucleus, lateral nuclear group of thalamus, medial geniculate nucleus, middle temporal gyrus, paraflocculus of cerebellum, parietal lobe, pars compacta, pars reticulata, pineal gland, subiculum, substantia nigra, supraoptic nucleus, tail of epididymis, vas deferens, ventral tegmental area. Use these groups to spot repeated connection types before inspecting the individual relationships.

KCND3

Top relations

Gene ontology · 33
KCND3 → A-type (transient outward) potassium channel activity, cardiac conduction, cell projection, dendrite, GABA-ergic synapse, integral component of membrane, integral component of postsynaptic specialization membrane, ion channel activity, ion transport, membrane, membrane repolarization, membrane repolarization during cardiac muscle cell action potential, membrane repolarization during ventricular cardiac muscle cell action potential, metal ion binding, plasma membrane, potassium channel activity, potassium ion export across plasma membrane, potassium ion transmembrane transport, potassium ion transport, protein binding
Bgee · 20
KCND3 → anterior amygdaloid area, Brodmann area 23, caput epididymis, cerebellar vermis, habenula, lateral geniculate nucleus, lateral nuclear group of thalamus, medial geniculate nucleus, middle temporal gyrus, paraflocculus of cerebellum, parietal lobe, pars compacta, pars reticulata, pineal gland, subiculum, substantia nigra, supraoptic nucleus, tail of epididymis, vas deferens, ventral tegmental area
RNA expression pattern · 20
KCND3 → anterior amygdaloid area, Brodmann area 23, caput epididymis, cerebellar vermis, habenula, lateral geniculate nucleus, lateral nuclear group of thalamus, medial geniculate nucleus, middle temporal gyrus, paraflocculus of cerebellum, parietal lobe, pars compacta, pars reticulata, pineal gland, subiculum, substantia nigra, supraoptic nucleus, tail of epididymis, vas deferens, ventral tegmental area
Band · 2
KCND3 → 1p13.2, 3|3 F2.2
Chr. · 2
KCND3 → Chromosome 1 (human), Chromosome 3 (mouse)
End · 2
KCND3 → 105,581,318 bp, 111,989,668 bp
Aliases · 1
KCND3 → KCND3, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22, BRGDA9, potassium voltage-gated channel subfamily D member 3
Available structures · 1
KCND3 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1S1G, 2NZ0
BioGPS · 1
KCND3 → More reference expression data
Databases · 1
KCND3 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

potassium voltage-gated channel bp human gene chr band member kv4 chromosome subfamily action potential location function protein also mouse ion

KCND3 relationships Subject–Predicate–Object triples

TTTA extracted 96 structured relationships around KCND3. Examples in this analysis include KCND3 → Aliases → KCND3, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22, BRGDA9, potassium voltage-gated channel subfamily D member 3 and KCND3 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1S1G, 2NZ0. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
KCND3AliasesKCND3, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22, BRGDA9, potassium voltage-gated channel subfamily D member 31.00infobox
KCND3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1S1G, 2NZ01.00infobox
KCND3Band1p13.21.00infobox
KCND3Band3|3 F2.21.00infobox
KCND3Bgeecerebellar vermis1.00infobox
KCND3Bgeepars reticulata1.00infobox
KCND3Bgeelateral nuclear group of thalamus1.00infobox
KCND3Bgeepars compacta1.00infobox
KCND3Bgeeparaflocculus of cerebellum1.00infobox
KCND3BgeeBrodmann area 231.00infobox
KCND3Bgeemiddle temporal gyrus1.00infobox
KCND3Bgeetail of epididymis1.00infobox
KCND3Bgeeparietal lobe1.00infobox
KCND3Bgeecaput epididymis1.00infobox
KCND3Bgeesubstantia nigra1.00infobox
KCND3Bgeeventral tegmental area1.00infobox
KCND3Bgeelateral geniculate nucleus1.00infobox
KCND3Bgeemedial geniculate nucleus1.00infobox
KCND3Bgeehabenula1.00infobox
KCND3Bgeevas deferens1.00infobox
KCND3Bgeeanterior amygdaloid area1.00infobox
KCND3Bgeesubiculum1.00infobox
KCND3Bgeepineal gland1.00infobox
KCND3Bgeesupraoptic nucleus1.00infobox
KCND3BioGPSMore reference expression data1.00infobox
KCND3Chr.Chromosome 1 (human)1.00infobox
KCND3Chr.Chromosome 3 (mouse)1.00infobox
KCND3DatabasesNCBI: entry; OMA: entry1.00infobox
KCND3End111,989,668 bp1.00infobox
KCND3End105,581,318 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around KCND3 bring nearby vocabulary together. In this analysis, examples include Protein, Search and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • KCND3
    • Protein
    • Search
    • Gene
    • Function
    • Location
    • Voltage-gated
    • Chromosome
    • Subfamily
    • Potassium
    • Bp
    • Chr
    • External
  • kcnd3
    • Protein
    • Search
    • Gene
    • Function
    • Location
    • Voltage-gated
    • Chromosome
    • Subfamily
    • Potassium
    • Bp
    • Chr
    • External
  • gene
    • Kcnd3
    • Location
    • Chromosome
    • Bp
    • Chr
    • Human
    • Member
    • End
    • F2
    • Mouse
    • Protein
    • Search
  • cardiac transient outward potassium current
    • Outward
    • Transient
    • Channel
    • Voltage-gated
    • Action
    • Potential
    • Subfamily
    • Kv4
    • Member
    • Kcnd3
    • End
    • Entry
  • phase 1 of the cardiac action potential
    • Outward
    • Potential
    • Transient
    • Action
    • Cardiac
    • Ion
    • Phase
    • Potassium
    • End
    • Entry
    • F2
    • Mouse
  • action potential
    • Potential
    • Cardiac
    • Ion
    • Outward
    • Phase
    • Transient
    • Potassium
    • Voltage-gated
    • Channel
    • End
    • Entry
    • F2
  • function
    • Search
    • Kcnd3
    • Location
    • Chromosome
    • Bp
    • Chr
    • Gene
    • Human
    • Kv4
    • Voltage-gated
    • End
    • Entry
  • protein
    • Cardiac
    • End
    • Entry
    • F2
    • Ion
    • Mouse
    • Ncbi
    • Outward
    • Q9uk17
    • Search
    • Transient
    • Uniprot

Connections between topic areas Semantic bridges

For KCND3, one of the stronger structural bridges in this analysis connects KCND3 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
KCND3Overview · splits 7 ⟂ 6
KCND3Function · splits 10 ⟂ 3
KCND3Clinical significance · splits 10 ⟂ 3

Map overview Semantic statistics

KCND3

Nodes13
Edges12
Triples96
Avg. degree1.85
Density0.153846
Components1

Source & methodology

TTTA analyzes the structure around KCND3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — KCND3 · EN edition · Analysis: TopicsToTalkAbout

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