Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Mucin-16: Structure, Role in cancer & Function

Mucin-16 (MUC-16) also known as Ovarian cancer-related tumor marker CA125 is a protein that in humans is encoded by the MUC16 gene. MUC-16 is a member of the mucin family glycoproteins. MUC-16 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, most notably ovarian…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

Mucin-16 topic overview

The analysis highlights Structure, Role in cancer and Function as prominent areas in the source structure around Mucin-16.

Related topics
52
Source areas
5
Connected nodes
57
Extracted relationships
54
Concept neighborhoods
17
Bridge connections
57

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 16 topics
Role in cancer · 15 topics
Function · 10 topics
Overview · 8 topics
Discovery · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
MUC16, CA125, mucin 16, cell surface associated
Band
19p13.2
Bgee
nasal epithelium · epithelium of bronchus · olfactory zone of nasal mucosa · bronchial epithelial cell · mucosa of paranasal sinus
BioGPS
n/a
Chr.
Chromosome 19 (human)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Role in cancer

Discovery

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Mucin-16 connects Entity context

The extracted context around Mucin-16 shows recurring relationship patterns in the source. For example, Mucin-16 → cell adhesion, extracellular exosome, extracellular region, extracellular space, extrinsic component of membrane, Golgi lumen, integral component of membrane, membrane, O-glycan processing, plasma membrane, protein binding, stimulatory C-type lectin receptor signaling pathway, vesicle Another extracted example is Mucin-16 → bronchial epithelial cell, epithelium of bronchus, epithelium of nasopharynx, minor salivary glands, mucosa of paranasal sinus, nasal epithelium, olfactory zone of nasal mucosa, palpebral conjunctiva, right uterine tube, trachea. Use these groups to spot repeated connection types before inspecting the individual relationships.

Mucin-16

Top relations

Gene ontology · 13
Mucin-16 → cell adhesion, extracellular exosome, extracellular region, extracellular space, extrinsic component of membrane, Golgi lumen, integral component of membrane, membrane, O-glycan processing, plasma membrane, protein binding, stimulatory C-type lectin receptor signaling pathway, vesicle
Bgee · 10
Mucin-16 → bronchial epithelial cell, epithelium of bronchus, epithelium of nasopharynx, minor salivary glands, mucosa of paranasal sinus, nasal epithelium, olfactory zone of nasal mucosa, palpebral conjunctiva, right uterine tube, trachea
RNA expression pattern · 10
Mucin-16 → bronchial epithelial cell, epithelium of bronchus, epithelium of nasopharynx, minor salivary glands, mucosa of paranasal sinus, nasal epithelium, olfactory zone of nasal mucosa, palpebral conjunctiva, right uterine tube, trachea
Aliases · 1
Mucin-16 → MUC16, CA125, mucin 16, cell surface associated
Band · 1
Mucin-16 → 19p13.2
BioGPS · 1
Mucin-16 → n/a
Chr. · 1
Mucin-16 → Chromosome 19 (human)
Databases · 1
Mucin-16 → NCBI: entry; OMA: entry
End · 1
Mucin-16 → 8,981,342 bp
Ensembl · 1
Mucin-16 → ENSG00000181143

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

muc16 cancer cell ovarian tumor ca-125 also mesothelin human domain cells protein mucin gene muc-16 extracellular bp may location surface

Mucin-16 relationships Subject–Predicate–Object triples

TTTA extracted 54 structured relationships around Mucin-16. Examples in this analysis include Mucin-16 → Aliases → MUC16, CA125, mucin 16, cell surface associated and Mucin-16 → Band → 19p13.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Mucin-16AliasesMUC16, CA125, mucin 16, cell surface associated1.00infobox
Mucin-16Band19p13.21.00infobox
Mucin-16Bgeenasal epithelium1.00infobox
Mucin-16Bgeeepithelium of bronchus1.00infobox
Mucin-16Bgeeolfactory zone of nasal mucosa1.00infobox
Mucin-16Bgeebronchial epithelial cell1.00infobox
Mucin-16Bgeemucosa of paranasal sinus1.00infobox
Mucin-16Bgeepalpebral conjunctiva1.00infobox
Mucin-16Bgeetrachea1.00infobox
Mucin-16Bgeeepithelium of nasopharynx1.00infobox
Mucin-16Bgeeright uterine tube1.00infobox
Mucin-16Bgeeminor salivary glands1.00infobox
Mucin-16BioGPSn/a1.00infobox
Mucin-16Chr.Chromosome 19 (human)1.00infobox
Mucin-16DatabasesNCBI: entry; OMA: entry1.00infobox
Mucin-16End8,981,342 bp1.00infobox
Mucin-16EnsemblENSG000001811431.00infobox
Mucin-16Entrez940251.00infobox
Mucin-16External IDsOMIM: 606154; GeneCards: MUC161.00infobox
Mucin-16Gene location (Human)Gene location (Human)Chr.Chromosome 19 (human)Band19p13.2Start8,848,844 bpEnd8,981,342 bp1.00infobox
Mucin-16Gene ontologyprotein binding1.00infobox
Mucin-16Gene ontologyGolgi lumen1.00infobox
Mucin-16Gene ontologyintegral component of membrane1.00infobox
Mucin-16Gene ontologyextracellular region1.00infobox
Mucin-16Gene ontologyvesicle1.00infobox
Mucin-16Gene ontologyextracellular exosome1.00infobox
Mucin-16Gene ontologymembrane1.00infobox
Mucin-16Gene ontologyextrinsic component of membrane1.00infobox
Mucin-16Gene ontologyextracellular space1.00infobox
Mucin-16Gene ontologyplasma membrane1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Mucin-16 bring nearby vocabulary together. In this analysis, examples include Cytoplasmic, Extracellular and Domain. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • tumor marker
    • Muc-16
    • Biomarker
    • Tumor
    • Cells
    • Blood
    • Ca125
    • Cancers
    • Conditions
    • Found
    • Invasion
    • Ovarian
    • Patients
  • biomarker
    • Marker
    • Blood
    • Bp
    • Ca125
    • Cancers
    • Chr
    • Chromosome
    • Conditions
    • Found
    • Invasion
    • Muc-16
    • Patients
  • ovarian cancer
    • Cancer
    • Ovarian
    • Conditions
    • Found
    • Patients
    • Ca-125
    • Cell
    • Blood
    • Cancers
    • Types
    • Protein
    • Role
  • squamous cell carcinoma
    • Mesothelin
    • Invasion
    • Surface
    • Human
    • Muc16
    • Domain
    • Bp
    • Chr
    • Chromosome
    • Expressed
    • Expression
    • Extracellular
  • role in cancer
    • Ovarian
    • Conditions
    • Found
    • Patients
    • Ca-125
    • Cell
    • Bp
    • Chr
    • Chromosome
    • Cancers
    • Role
    • Types
  • gene
    • Location
    • Human
    • Bp
    • Chr
    • Chromosome
    • Mucin
    • Protein
    • Biomarker
    • Marker
    • Membrane
    • Cell
    • Muc16
  • protein
    • Cytoplasmic
    • Extracellular
    • Domain
    • Cell
    • Membrane
    • Bp
    • C-terminal
    • Chr
    • Chromosome
    • Expressed
    • Expression
    • Location
  • erm protein family
    • Cytoplasmic
    • Extracellular
    • Domain
    • Cell
    • Membrane
    • Bp
    • C-terminal
    • Chr
    • Chromosome
    • Expressed
    • Expression
    • Location

Connections between topic areas Semantic bridges

For Mucin-16, one of the stronger structural bridges in this analysis connects Mucin-16 with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Mucin-16Structure · splits 41 ⟂ 17
Mucin-16Role in cancer · splits 42 ⟂ 16
Mucin-16Function · splits 47 ⟂ 11
Mucin-16Overview · splits 49 ⟂ 9
Mucin-16Discovery · splits 54 ⟂ 4

Map overview Semantic statistics

Mucin-16

Nodes58
Edges57
Triples54
Avg. degree1.97
Density0.034483
Components1

Source & methodology

TTTA analyzes the structure around Mucin-16 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Role in cancer & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Mucin-16 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.