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DKK1: Research, Function & In vitro studies

Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene.

Language: English [EN]
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DKK1 topic overview

The analysis highlights Research, Function and In vitro studies as prominent areas in the source structure around DKK1.

Related topics
22
Source areas
7
Connected nodes
29
Extracted relationships
152
Concept neighborhoods
16
Bridge connections
29

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 6 topics
In vitro studies · 5 topics
DKK1 and Alzheimer's · 4 topics
Clinical significance · 2 topics
Interactions · 2 topics
Overview · 2 topics
Animal studies · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
DKK1, DKK-1, SK, dickkopf WNT signaling pathway inhibitor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S2K, 3S8V, 3SOQ, 5FWW
Band
10q21.1 · 19|19 C1
Bgee
decidua · stromal cell of endometrium · mucosa of urinary bladder · epithelium of esophagus · tibia
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 19 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Clinical significance

Animal studies

In vitro studies

DKK1 and Alzheimer's

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How DKK1 connects Entity context

The extracted context around DKK1 shows recurring relationship patterns in the source. For example, DKK1 → cell morphogenesis involved in differentiation, co-receptor binding, early endosome membrane, embryonic limb morphogenesis, endoderm development, endoderm formation, extracellular negative regulation of signal transduction, extracellular region, extracellular space, face morphogenesis, forebrain development, growth factor activity, hair follicle development, head morphogenesis, learning or memory, limb development, low-density lipoprotein particle receptor binding, mesoderm formation, motor learning, multicellular organism development Another extracted example is DKK1 → calvaria, canal of the cervix, decidua, dermis, desmocranium, epithelium of esophagus, eyelid, fossa, gonad, Jacobson's organ, mandible, maxilla, membranous bone, molar, mucosa of urinary bladder, skin of leg, sperm, stromal cell of endometrium, tibia, vagina. Use these groups to spot repeated connection types before inspecting the individual relationships.

DKK1

Top relations

Gene ontology · 61
DKK1 → cell morphogenesis involved in differentiation, co-receptor binding, early endosome membrane, embryonic limb morphogenesis, endoderm development, endoderm formation, extracellular negative regulation of signal transduction, extracellular region, extracellular space, face morphogenesis, forebrain development, growth factor activity, hair follicle development, head morphogenesis, learning or memory, limb development, low-density lipoprotein particle receptor binding, mesoderm formation, motor learning, multicellular organism development
Bgee · 20
DKK1 → calvaria, canal of the cervix, decidua, dermis, desmocranium, epithelium of esophagus, eyelid, fossa, gonad, Jacobson's organ, mandible, maxilla, membranous bone, molar, mucosa of urinary bladder, skin of leg, sperm, stromal cell of endometrium, tibia, vagina
RNA expression pattern · 20
DKK1 → calvaria, canal of the cervix, decidua, dermis, desmocranium, epithelium of esophagus, eyelid, fossa, gonad, Jacobson's organ, mandible, maxilla, membranous bone, molar, mucosa of urinary bladder, skin of leg, sperm, stromal cell of endometrium, tibia, vagina
related to Function · 7
DKK1 → Dickkopf WNT, It, LRP6, The, This, Wnt, Wnt/β-catenin
related to DKK1 and Alzheimer's · 6
DKK1 → Alzheimer's, Because, Downregulation, In, The Wnt, Wnt
related to In vitro studies · 5
DKK1 → DHT, DKK-1, L-threonate, Neutralizing, RNA
related to Animal studies · 4
DKK1 → All, Scientists, This, Wnt
Band · 2
DKK1 → 10q21.1, 19|19 C1
Chr. · 2
DKK1 → Chromosome 10 (human), Chromosome 19 (mouse)
End · 2
DKK1 → 30,527,065 bp, 52,318,042 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

signaling gene wnt pathway bp chr human band protein development chromosome 10 dickkopf alzheimer's dkk-1 location function vitro mouse bone

DKK1 relationships Subject–Predicate–Object triples

TTTA extracted 152 structured relationships around DKK1. Examples in this analysis include DKK1 → Aliases → DKK1, DKK-1, SK, dickkopf WNT signaling pathway inhibitor 1 and DKK1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S2K, 3S8V, 3SOQ, 5FWW. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DKK1AliasesDKK1, DKK-1, SK, dickkopf WNT signaling pathway inhibitor 11.00infobox
DKK1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S2K, 3S8V, 3SOQ, 5FWW1.00infobox
DKK1Band10q21.11.00infobox
DKK1Band19|19 C11.00infobox
DKK1Bgeedecidua1.00infobox
DKK1Bgeestromal cell of endometrium1.00infobox
DKK1Bgeemucosa of urinary bladder1.00infobox
DKK1Bgeeepithelium of esophagus1.00infobox
DKK1Bgeetibia1.00infobox
DKK1Bgeecanal of the cervix1.00infobox
DKK1Bgeegonad1.00infobox
DKK1Bgeesperm1.00infobox
DKK1Bgeeskin of leg1.00infobox
DKK1Bgeevagina1.00infobox
DKK1Bgeemembranous bone1.00infobox
DKK1Bgeemandible1.00infobox
DKK1Bgeedesmocranium1.00infobox
DKK1Bgeecalvaria1.00infobox
DKK1Bgeeeyelid1.00infobox
DKK1BgeeJacobson's organ1.00infobox
DKK1Bgeemolar1.00infobox
DKK1Bgeedermis1.00infobox
DKK1Bgeefossa1.00infobox
DKK1Bgeemaxilla1.00infobox
DKK1BioGPSMore reference expression data1.00infobox
DKK1Chr.Chromosome 10 (human)1.00infobox
DKK1Chr.Chromosome 19 (mouse)1.00infobox
DKK1DatabasesNCBI: entry; OMA: entry1.00infobox
DKK1End52,318,042 bp1.00infobox
DKK1End30,527,065 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around DKK1 bring nearby vocabulary together. In this analysis, examples include Signaling, Pathway and Wnt. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • DKK1
    • Signaling
    • Pathway
    • Wnt
    • Gene
    • Dickkopf
    • Bone
    • Alzheimer's
    • Protein
    • Development
    • Encoded
    • Inhibitor
    • Interact
  • dkk1
    • Signaling
    • Pathway
    • Wnt
    • Gene
    • Dickkopf
    • Bone
    • Alzheimer's
    • Protein
    • Development
    • Encoded
    • Inhibitor
    • Interact
  • gene
    • Location
    • Chromosome
    • Dickkopf
    • Human
    • Bp
    • Chr
    • End
    • Inhibitor
    • Mouse
    • Search
    • Function
    • Pathway
  • dickkopf
    • Inhibitor
    • Pathway
    • Search
    • Wnt
    • Signaling
    • Gene
    • Function
    • Location
    • Chromosome
    • Human
    • Protein
    • Bp
  • wnt signaling pathway
    • Pathway
    • Wnt
    • Signaling
    • Dickkopf
    • Development
    • Dkk1
    • Protein
    • Gene
    • Inhibitor
    • Search
    • Function
    • Inhibition
  • function
    • Search
    • Location
    • Alzheimer's
    • Chromosome
    • Dickkopf
    • Human
    • Bp
    • Chr
    • Gene
    • End
    • Inhibitor
    • Morphogenesis
  • dkk1 and alzheimer's
    • Signaling
    • Function
    • Pathway
    • Wnt
    • Gene
    • Dickkopf
    • Bone
    • Inhibitor
    • Search
    • Structures
    • Alzheimer's
    • Dkk1
  • osteolytic bone lesions
    • End
    • Morphogenesis
    • Mouse
    • Rna
    • Search
    • Dkk1
    • Due
    • Function
    • Location
    • Neuron
    • Chromosome
    • Dickkopf

Connections between topic areas Semantic bridges

For DKK1, one of the stronger structural bridges in this analysis connects DKK1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DKK1Function · splits 23 ⟂ 7
DKK1In vitro studies · splits 24 ⟂ 6
DKK1DKK1 and Alzheimer's · splits 25 ⟂ 5
DKK1Overview · splits 27 ⟂ 3
DKK1Interactions · splits 27 ⟂ 3
DKK1Clinical significance · splits 27 ⟂ 3

Map overview Semantic statistics

DKK1

Nodes30
Edges29
Triples152
Avg. degree1.93
Density0.066667
Components1

Source & methodology

TTTA analyzes the structure around DKK1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, Function & In vitro studies, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — DKK1 · EN edition · Analysis: TopicsToTalkAbout

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