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DKK1

Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene.

Research, Function & In vitro studies

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Aliases
DKK1, DKK-1, SK, dickkopf WNT signaling pathway inhibitor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S2K, 3S8V, 3SOQ, 5FWW
Band
10q21.1 · 19|19 C1
Bgee
decidua · stromal cell of endometrium · mucosa of urinary bladder · epithelium of esophagus · tibia
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 19 (mouse)

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Overview

Function

Interactions

Clinical significance

Animal studies

In vitro studies

DKK1 and Alzheimer's

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Map overview Semantic statistics

DKK1

Nodes30
Edges29
Triples152
Avg. degree1.93
Density0.066667
Components1

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DKK1

Top relations

Gene ontology · 61
DKK1 → cell morphogenesis involved in differentiation, co-receptor binding, early endosome membrane, embryonic limb morphogenesis, endoderm development, endoderm formation, extracellular negative regulation of signal transduction, extracellular region, extracellular space, face morphogenesis, forebrain development, growth factor activity, hair follicle development, head morphogenesis, learning or memory, limb development, low-density lipoprotein particle receptor binding, mesoderm formation, motor learning, multicellular organism development
Bgee · 20
DKK1 → calvaria, canal of the cervix, decidua, dermis, desmocranium, epithelium of esophagus, eyelid, fossa, gonad, Jacobson's organ, mandible, maxilla, membranous bone, molar, mucosa of urinary bladder, skin of leg, sperm, stromal cell of endometrium, tibia, vagina
RNA expression pattern · 20
DKK1 → calvaria, canal of the cervix, decidua, dermis, desmocranium, epithelium of esophagus, eyelid, fossa, gonad, Jacobson's organ, mandible, maxilla, membranous bone, molar, mucosa of urinary bladder, skin of leg, sperm, stromal cell of endometrium, tibia, vagina
related to Function · 7
DKK1 → Dickkopf WNT, It, LRP6, The, This, Wnt, Wnt/β-catenin
related to DKK1 and Alzheimer's · 6
DKK1 → Alzheimer's, Because, Downregulation, In, The Wnt, Wnt
related to In vitro studies · 5
DKK1 → DHT, DKK-1, L-threonate, Neutralizing, RNA
related to Animal studies · 4
DKK1 → All, Scientists, This, Wnt
Band · 2
DKK1 → 10q21.1, 19|19 C1
Chr. · 2
DKK1 → Chromosome 10 (human), Chromosome 19 (mouse)
End · 2
DKK1 → 30,527,065 bp, 52,318,042 bp

Important terminology Word statistics

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Important terminology

signaling gene wnt pathway bp chr human band protein development chromosome 10 dickkopf alzheimer's dkk-1 location function vitro mouse bone

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DKK1AliasesDKK1, DKK-1, SK, dickkopf WNT signaling pathway inhibitor 11.00infobox
DKK1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S2K, 3S8V, 3SOQ, 5FWW1.00infobox
DKK1Band10q21.11.00infobox
DKK1Band19|19 C11.00infobox
DKK1Bgeedecidua1.00infobox
DKK1Bgeestromal cell of endometrium1.00infobox
DKK1Bgeemucosa of urinary bladder1.00infobox
DKK1Bgeeepithelium of esophagus1.00infobox
DKK1Bgeetibia1.00infobox
DKK1Bgeecanal of the cervix1.00infobox
DKK1Bgeegonad1.00infobox
DKK1Bgeesperm1.00infobox
DKK1Bgeeskin of leg1.00infobox
DKK1Bgeevagina1.00infobox
DKK1Bgeemembranous bone1.00infobox
DKK1Bgeemandible1.00infobox
DKK1Bgeedesmocranium1.00infobox
DKK1Bgeecalvaria1.00infobox
DKK1Bgeeeyelid1.00infobox
DKK1BgeeJacobson's organ1.00infobox
DKK1Bgeemolar1.00infobox
DKK1Bgeedermis1.00infobox
DKK1Bgeefossa1.00infobox
DKK1Bgeemaxilla1.00infobox
DKK1BioGPSMore reference expression data1.00infobox
DKK1Chr.Chromosome 10 (human)1.00infobox
DKK1Chr.Chromosome 19 (mouse)1.00infobox
DKK1DatabasesNCBI: entry; OMA: entry1.00infobox
DKK1End52,318,042 bp1.00infobox
DKK1End30,527,065 bp1.00infobox

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