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Dickkopf

Dickkopf (DKK) is a family of proteins consisting of five members as of 2020. That is, vertebrates usually contain five genes that are members of the family. The most well-studied is Dickkopf-related protein 1 (DKK1). DKK proteins inhibit the Wnt signaling pathway coreceptors LRP5 and LRP6. They bind with high affinity as ligands to KREMEN1 and KREMEN2…

Structure, Etymology & Proteins

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Structure

GlycoproteinsAmino acidsMolecular weightsDaCysteine
6 related topics

Etymology

GermanNatureEmbryogenesisXenopus
4 related topics

Proteins

DKK2DKK3DKK4DKKL1
4 related topics

Human disease

PathophysiologyArteryAtherosclerosis
3 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Domains
InterPro
HGNC
2891
Locus
Chr. 10 q21.1
NCBI gene
22943
OMIM
605189
RefSeq
NP_036374

Topics to explore

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Overview

Etymology

Structure

Proteins

Human disease

Advanced semantic analysis

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Map overview Semantic statistics

Dickkopf

Nodes33
Edges32
Triples16
Avg. degree1.94
Density0.060606
Components1

How this topic connects Entity context

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Dickkopf

Top relations

related to Etymology · 6
Dickkopf → DKK1, German, Glinka, It, Nature, Xenopus
Domains · 1
Dickkopf → InterPro
HGNC · 1
Dickkopf → 2891
Locus · 1
Dickkopf → Chr. 10 q21.1
NCBI gene · 1
Dickkopf → 22943
OMIM · 1
Dickkopf → 605189
RefSeq · 1
Dickkopf → NP_036374
Search for · 1
Dickkopf → Search forStructuresSwiss-modelDomainsInterPro
Structures · 1
Dickkopf → Swiss-model
Symbol · 1
Dickkopf → DKK1

Important terminology Word statistics

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Important terminology

proteins dkk1 dkk vertebrates dkk3 family five members consisting protein high chr 10 q21 human disease dkk2 dkk4 domains lrp5

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DickkopfDomainsInterPro1.00infobox
DickkopfHGNC28911.00infobox
DickkopfLocusChr. 10 q21.11.00infobox
DickkopfNCBI gene229431.00infobox
DickkopfOMIM6051891.00infobox
DickkopfRefSeqNP_0363741.00infobox
DickkopfSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
DickkopfStructuresSwiss-model1.00infobox
DickkopfSymbolDKK11.00infobox
DickkopfUniProtO949071.00infobox
Dickkopfrelated to EtymologyGerman0.60section
Dickkopfrelated to EtymologyIt0.60section

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    Min side: 3
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