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Interleukin 3: Function, Receptor & Immunological therapy

Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. Sometimes also called colony-stimulating factor, multi-CSF, mast cell growth factor, MULTI-CSF, MCGF; MGC79398, MGC79399: after removal of the signal peptide sequence, the mature protein contains 133 amino acids in its polypeptide chain. IL-3 is…

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Interleukin 3 topic overview

The analysis highlights Function, Receptor and Immunological therapy as prominent areas in the source structure around Interleukin 3.

Related topics
47
Source areas
6
Connected nodes
53
Extracted relationships
69
Concept neighborhoods
23
Bridge connections
53

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 27 topics
Overview · 8 topics
Receptor · 7 topics
Immunological therapy · 2 topics
Interactions · 2 topics
Disease · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
IL3, interleukin 3, IL-3, MCGF, MULTI-CSF
Available structures
Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1JLI
Band
5q31.1
Bgee
Achilles tendon · bone marrow · lymph node · appendix
BioGPS
More reference expression data
Chr.
Chromosome 5 (human)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Receptor

Disease

Immunological therapy

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Interleukin 3 connects Entity context

The extracted context around Interleukin 3 shows recurring relationship patterns in the source. For example, Interleukin 3 → cell-cell signaling, cytokine activity, cytokine-mediated signaling pathway, embryonic hemopoiesis, extracellular region, extracellular space, fever generation, growth factor activity, immune response, interleukin-1 receptor binding, interleukin-3 receptor binding, intracellular anatomical structure, MAPK cascade, nervous system development, peptidyl-tyrosine phosphorylation, positive regulation of cell population proliferation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of tyrosine phosphorylation of STAT protein, protein tyrosine kinase activity, regulation of cytokine-mediated signaling pathway Another extracted example is Interleukin 3 → CSF, GM-CSF, However, IgG, IL-3, IL-5, In, Interleukin. Use these groups to spot repeated connection types before inspecting the individual relationships.

Interleukin 3

Top relations

Gene ontology · 21
Interleukin 3 → cell-cell signaling, cytokine activity, cytokine-mediated signaling pathway, embryonic hemopoiesis, extracellular region, extracellular space, fever generation, growth factor activity, immune response, interleukin-1 receptor binding, interleukin-3 receptor binding, intracellular anatomical structure, MAPK cascade, nervous system development, peptidyl-tyrosine phosphorylation, positive regulation of cell population proliferation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of tyrosine phosphorylation of STAT protein, protein tyrosine kinase activity, regulation of cytokine-mediated signaling pathway
related to Function · 8
Interleukin 3 → CSF, GM-CSF, However, IgG, IL-3, IL-5, In, Interleukin
related to Discovery · 6
Interleukin 3 → Ginsberg, IL-3, In, Interleukin, Sachs, The
Bgee · 4
Interleukin 3 → Achilles tendon, appendix, bone marrow, lymph node
RNA expression pattern · 4
Interleukin 3 → Achilles tendon, appendix, bone marrow, lymph node
related to Interactions · 2
Interleukin 3 → IL3RA, Interleukin
Aliases · 1
Interleukin 3 → IL3, interleukin 3, IL-3, MCGF, MULTI-CSF
Available structures · 1
Interleukin 3 → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1JLI
Band · 1
Interleukin 3 → 5q31.1
BioGPS · 1
Interleukin 3 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

il-3 cells cell interleukin factor also human gene receptor proliferation chromosome protein growth gm-csf cytokine function produced activated differentiation il3

Interleukin 3 relationships Subject–Predicate–Object triples

TTTA extracted 69 structured relationships around Interleukin 3. Examples in this analysis include Interleukin 3 → Aliases → IL3, interleukin 3, IL-3, MCGF, MULTI-CSF and Interleukin 3 → Available structures → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1JLI. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Interleukin 3AliasesIL3, interleukin 3, IL-3, MCGF, MULTI-CSF1.00infobox
Interleukin 3Available structuresAvailable structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1JLI1.00infobox
Interleukin 3Band5q31.11.00infobox
Interleukin 3BgeeAchilles tendon1.00infobox
Interleukin 3Bgeebone marrow1.00infobox
Interleukin 3Bgeelymph node1.00infobox
Interleukin 3Bgeeappendix1.00infobox
Interleukin 3BioGPSMore reference expression data1.00infobox
Interleukin 3Chr.Chromosome 5 (human)1.00infobox
Interleukin 3DatabasesNCBI: entry; OMA: entry1.00infobox
Interleukin 3End132,063,204 bp1.00infobox
Interleukin 3EnsemblENSG000001643991.00infobox
Interleukin 3Entrez35621.00infobox
Interleukin 3External IDsOMIM: 147740; GeneCards: IL31.00infobox
Interleukin 3Gene location (Human)Gene location (Human)Chr.Chromosome 5 (human)Band5q31.1Start132,060,655 bpEnd132,063,204 bp1.00infobox
Interleukin 3Gene ontologygrowth factor activity1.00infobox
Interleukin 3Gene ontologyinterleukin-3 receptor binding1.00infobox
Interleukin 3Gene ontologycytokine activity1.00infobox
Interleukin 3Gene ontologyprotein tyrosine kinase activity1.00infobox
Interleukin 3Gene ontologyinterleukin-1 receptor binding1.00infobox
Interleukin 3Gene ontologyextracellular region1.00infobox
Interleukin 3Gene ontologyintracellular anatomical structure1.00infobox
Interleukin 3Gene ontologyextracellular space1.00infobox
Interleukin 3Gene ontologyMAPK cascade1.00infobox
Interleukin 3Gene ontologyembryonic hemopoiesis1.00infobox
Interleukin 3Gene ontologycell-cell signaling1.00infobox
Interleukin 3Gene ontologynervous system development1.00infobox
Interleukin 3Gene ontologypositive regulation of peptidyl-tyrosine phosphorylation1.00infobox
Interleukin 3Gene ontologyimmune response1.00infobox
Interleukin 3Gene ontologypeptidyl-tyrosine phosphorylation1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Interleukin 3 bring nearby vocabulary together. In this analysis, examples include Il3, Uniprot and Chromosome. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Interleukin 3
    • Il3
    • Uniprot
    • Chromosome
    • Gene
    • Bp
    • Chr
    • Function
    • Protein
    • Interleukin-3
    • Human
    • Receptor
    • Band
  • interleukin 3
    • Il3
    • Uniprot
    • Chromosome
    • Gene
    • Bp
    • Chr
    • Function
    • Protein
    • Interleukin-3
    • Human
    • Receptor
    • Band
  • gene
    • Chromosome
    • Human
    • Il3
    • Function
    • Protein
    • Interleukin
    • Bp
    • Chr
    • Uniprot
    • Receptor
    • Factor
    • Band
  • cytokine
    • Function
    • Interleukin-3
    • Band
    • Bone
    • Bp
    • Chr
    • Il3
    • Immune
    • Marrow
    • Response
    • Signal
    • Types
  • stem cells
    • Il-3
    • Differentiation
    • Produced
    • Proliferation
    • Early
    • Factor
    • Induces
    • Cells
    • Stem
    • Hematopoietic
    • Gm-csf
    • Monocytes
  • interleukin
    • Il3
    • Uniprot
    • Chromosome
    • Gene
    • Bp
    • Chr
    • Function
    • Protein
    • Interleukin-3
    • Human
    • Receptor
    • Band
  • multipotent hematopoietic stem cells
    • Il-3
    • Differentiation
    • Produced
    • Proliferation
    • Early
    • Factor
    • Induces
    • Cells
    • Stem
    • Hematopoietic
    • Gm-csf
    • Interleukin-3
  • chromosome 5
    • Bp
    • Chr
    • Il3
    • Gene
    • Human
    • Function
    • Band
    • Interleukin
    • Uniprot
    • Protein
    • Receptor
    • Bone

Connections between topic areas Semantic bridges

For Interleukin 3, one of the stronger structural bridges in this analysis connects Interleukin 3 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Interleukin 3Function · splits 26 ⟂ 28
Interleukin 3Overview · splits 45 ⟂ 9
Interleukin 3Receptor · splits 46 ⟂ 8
Interleukin 3Immunological therapy · splits 51 ⟂ 3
Interleukin 3Interactions · splits 51 ⟂ 3

Map overview Semantic statistics

Interleukin 3

Nodes54
Edges53
Triples69
Avg. degree1.96
Density0.037037
Components1

Source & methodology

TTTA analyzes the structure around Interleukin 3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Receptor & Immunological therapy, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Interleukin 3 · EN edition · Analysis: TopicsToTalkAbout

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