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Histamine H2 receptor: Art, Measurement & Products

H2 receptors are a type of histamine receptor found in many parts of the anatomy of humans and other animals. They are positively coupled to adenylate cyclase via Gs alpha subunit. It is a potent stimulant of cAMP production, which leads to activation of protein kinase A. PKA functions to phosphorylate certain proteins, affecting their activity. The drug…

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Histamine H2 receptor topic overview

The analysis highlights Art, Measurement and Products as prominent areas in the source structure around Histamine H2 receptor. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
38
Source areas
4
Connected nodes
43
Extracted relationships
102
Concept neighborhoods
13
Bridge connections
43

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Tissue distribution · 15 topics
Physiological responses · 12 topics
Function · 6 topics
Overview · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
HRH2, H2R, histamine receptor H2, HH2R
Band
5q35.2 · 13 B1|13 28.4 cM
Bgee
monocyte · blood · granulocyte · left ventricle · apex of heart
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 13 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Tissue distribution

Physiological responses

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Histamine H2 receptor connects Entity context

The extracted context around Histamine H2 receptor shows recurring relationship patterns in the source. For example, Histamine H2 receptor → chemical synaptic transmission, dendrite, digestive tract development, epithelial cell morphogenesis, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, G protein-coupled serotonin receptor activity, G protein-coupled serotonin receptor signaling pathway, gastric acid secretion, gastrin-induced gastric acid secretion, gland development, histamine receptor activity, histamine-induced gastric acid secretion, immune response, integral component of membrane, integral component of plasma membrane, membrane, memory, neurotransmitter receptor activity Another extracted example is Histamine H2 receptor → apex of heart, blood, body of stomach, caudate nucleus, decidua, dentate gyrus of hippocampal formation granule cell, epithelium of stomach, granulocyte, internal carotid artery, left ventricle, monocyte, mucous cell of stomach, myocardium of left ventricle, neuron, prefrontal cortex, primary visual cortex, putamen, superior frontal gyrus. Use these groups to spot repeated connection types before inspecting the individual relationships.

Histamine H2 receptor

Top relations

Gene ontology · 27
Histamine H2 receptor → chemical synaptic transmission, dendrite, digestive tract development, epithelial cell morphogenesis, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, G protein-coupled serotonin receptor activity, G protein-coupled serotonin receptor signaling pathway, gastric acid secretion, gastrin-induced gastric acid secretion, gland development, histamine receptor activity, histamine-induced gastric acid secretion, immune response, integral component of membrane, integral component of plasma membrane, membrane, memory, neurotransmitter receptor activity
Bgee · 18
Histamine H2 receptor → apex of heart, blood, body of stomach, caudate nucleus, decidua, dentate gyrus of hippocampal formation granule cell, epithelium of stomach, granulocyte, internal carotid artery, left ventricle, monocyte, mucous cell of stomach, myocardium of left ventricle, neuron, prefrontal cortex, primary visual cortex, putamen, superior frontal gyrus
RNA expression pattern · 18
Histamine H2 receptor → apex of heart, blood, body of stomach, caudate nucleus, decidua, dentate gyrus of hippocampal formation granule cell, epithelium of stomach, granulocyte, internal carotid artery, left ventricle, monocyte, mucous cell of stomach, myocardium of left ventricle, neuron, prefrontal cortex, primary visual cortex, putamen, superior frontal gyrus
related to Physiological responses · 16
Histamine H2 receptor → Activation, COPD, Experimental, GERD, H2, Inhibit, Inhibition, MLC, MLCK, MLCP, PKA, Smooth, Stimulation, T-cell, Target, The
related to Tissue distribution · 3
Histamine H2 receptor → Gastric, Histamine H2, Vascular
Band · 2
Histamine H2 receptor → 13 B1|13 28.4 cM, 5q35.2
Chr. · 2
Histamine H2 receptor → Chromosome 13 (mouse), Chromosome 5 (human)
End · 2
Histamine H2 receptor → 175,710,756 bp, 54,390,199 bp
Aliases · 1
Histamine H2 receptor → HRH2, H2R, histamine receptor H2, HH2R
BioGPS · 1
Histamine H2 receptor → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

histamine h2 receptor bp receptors chr human band chromosome secretion protein activity gene location external activation hrh2 mouse pka gastric

Histamine H2 receptor relationships Subject–Predicate–Object triples

TTTA extracted 102 structured relationships around Histamine H2 receptor. Examples in this analysis include Histamine H2 receptor → Aliases → HRH2, H2R, histamine receptor H2, HH2R and Histamine H2 receptor → Band → 5q35.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Histamine H2 receptorAliasesHRH2, H2R, histamine receptor H2, HH2R1.00infobox
Histamine H2 receptorBand5q35.21.00infobox
Histamine H2 receptorBand13 B1|13 28.4 cM1.00infobox
Histamine H2 receptorBgeemonocyte1.00infobox
Histamine H2 receptorBgeeblood1.00infobox
Histamine H2 receptorBgeegranulocyte1.00infobox
Histamine H2 receptorBgeeleft ventricle1.00infobox
Histamine H2 receptorBgeeapex of heart1.00infobox
Histamine H2 receptorBgeebody of stomach1.00infobox
Histamine H2 receptorBgeeputamen1.00infobox
Histamine H2 receptorBgeecaudate nucleus1.00infobox
Histamine H2 receptorBgeemyocardium of left ventricle1.00infobox
Histamine H2 receptorBgeeprefrontal cortex1.00infobox
Histamine H2 receptorBgeeinternal carotid artery1.00infobox
Histamine H2 receptorBgeeepithelium of stomach1.00infobox
Histamine H2 receptorBgeemucous cell of stomach1.00infobox
Histamine H2 receptorBgeeprimary visual cortex1.00infobox
Histamine H2 receptorBgeesuperior frontal gyrus1.00infobox
Histamine H2 receptorBgeeneuron1.00infobox
Histamine H2 receptorBgeedecidua1.00infobox
Histamine H2 receptorBgeedentate gyrus of hippocampal formation granule cell1.00infobox
Histamine H2 receptorBioGPSMore reference expression data1.00infobox
Histamine H2 receptorChr.Chromosome 5 (human)1.00infobox
Histamine H2 receptorChr.Chromosome 13 (mouse)1.00infobox
Histamine H2 receptorDatabasesNCBI: entry; OMA: entry1.00infobox
Histamine H2 receptorEnd175,710,756 bp1.00infobox
Histamine H2 receptorEnd54,390,199 bp1.00infobox
Histamine H2 receptorEnsemblENSG000001137491.00infobox
Histamine H2 receptorEntrez32741.00infobox
Histamine H2 receptorExternal IDsOMIM: 142703; MGI: 108482; GeneCards: HRH21.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Histamine H2 receptor bring nearby vocabulary together. In this analysis, examples include Histamine, Receptor and Receptors. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Histamine H2 receptor
    • Histamine
    • Receptor
    • Receptors
    • Agonist
    • Caudate
    • External
    • Function
    • Heart
    • Hrh2
    • Physiological
    • Putamen
    • Acid
  • histamine h2 receptor
    • Histamine
    • Receptor
    • Receptors
    • Agonist
    • Caudate
    • External
    • Function
    • Heart
    • Hrh2
    • Physiological
    • Putamen
    • Acid
  • histamine
    • Receptor
    • Receptors
    • Agonist
    • Caudate
    • External
    • Function
    • Heart
    • Hrh2
    • Physiological
    • Putamen
    • Acid
    • Activation
  • caudate
    • Heart
    • Putamen
    • Acid
    • Gastric
    • Secretion
    • Coupled
    • End
    • External
    • Function
    • Hrh2
    • Membrane
    • Mouse
  • gastric acid
    • Gastric
    • Secretion
    • Caudate
    • Heart
    • Membrane
    • Putamen
    • Activity
    • Protein
    • Receptor
    • Agonist
    • B1
    • Coupled
  • function
    • Hrh2
    • Gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • B1
    • Caudate
    • Coupled
    • End
    • External
  • heart
    • Putamen
    • Gastric
    • Secretion
    • Coupled
    • Hrh2
    • Membrane
    • Mouse
    • Physiological
    • Pka
    • Production
    • Receptor
    • Location
  • physiological responses
    • Caudate
    • Heart
    • Pka
    • Production
    • Putamen
    • Receptor
    • Acid
    • Gastric
    • Gene
    • Location
    • Human
    • Secretion

Connections between topic areas Semantic bridges

For Histamine H2 receptor, one of the stronger structural bridges in this analysis connects Histamine H2 receptor with Tissue distribution. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Histamine H2 receptorTissue distribution · splits 28 ⟂ 16
Histamine H2 receptorPhysiological responses · splits 31 ⟂ 13
Histamine H2 receptorOverview · splits 37 ⟂ 7
Histamine H2 receptorFunction · splits 37 ⟂ 7

Map overview Semantic statistics

Histamine H2 receptor

Nodes44
Edges43
Triples102
Avg. degree1.95
Density0.045455
Components1

Source & methodology

TTTA analyzes the structure around Histamine H2 receptor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Measurement & Products, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Histamine H2 receptor · EN edition · Analysis: TopicsToTalkAbout

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