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Folinic acid

Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, and may be used to treat folate deficiency, anemia, and methanol poisoning. It is taken by mouth, injection into a muscle, or…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
V03AF03 (WHO)
Bioavailability
Dose dependent
CAS Number
1492-18-8
ChEMBL
ChEMBL1679

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Overview

Medical uses

Side effects

Drug interactions

Biochemistry

Mechanism of action

History

Society and culture

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Map overview Semantic statistics

Folinic acid

Nodes76
Edges75
Triples101
Avg. degree1.97
Density0.026316
Components1

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Folinic acid

Top relations

related to history · 13
Folinic acid → Baumann, Drug Administration, FDA, FDA's, Folinic, From, In September, It, Leuconostoc, Sauberlich, The, This, US Food
related to Biochemistry · 9
Folinic acid → According, AICARFT, In, It, MTHF, MTHFR, MTHFS, SHMT, THF
related to Cerebral folate deficiency · 9
Folinic acid → As, CFD, CSF, Drug Administration, FDA, Folinic, MTHF, This, US Food
related to Mechanism of action · 8
Folinic acid → Although, DNA, Folinic, In, It, One, Since, This
has effect · 7
Folinic acid → Different, Folinic, However, In, Severe, This, While
related to Names · 7
Folinic acid → B9, Folinic, However, INN, It, Levofolinic, They
related to Drug interactions · 6
Folinic acid → AIDS, Fluorouracil, Folinic, Pneumocystis, Some, Sulfamethoxazole-trimethoprim
related to Autism spectrum disorder · 5
Folinic acid → All, ASD, December, Folinic, In January
related to Other uses or indications · 4
Folinic acid → Folinic, In, It, Its
is a · 2
Folinic acid → form of folic acid that does not require activation by dihydrofolate reductase to be useful to the body.Folinic acid was first made in 1945, vitamer of folic acid and has the full vitamin activity of this vitamin

Important terminology Word statistics

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Important terminology

acid folinic folate methotrexate used leucovorin also deficiency treatment may effects folic calcium dihydrofolate reductase known drug cerebral citrovorum factor

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Folinic acid3D model (JSmol)Interactive image1.00infobox
Folinic acidAHFS/Drugs.comMonograph1.00infobox
Folinic acidATC codeV03AF03 (WHO)1.00infobox
Folinic acidBioavailabilityDose dependent1.00infobox
Folinic acidCAS Number1492-18-81.00infobox
Folinic acidChEMBLChEMBL16791.00infobox
Folinic acidChemSpider57841.00infobox
Folinic acidCompTox Dashboard (EPA)DTXSID00482161.00infobox
Folinic acidDrugBankDB006501.00infobox
Folinic acidECHA InfoCard100.000.3281.00infobox
Folinic acidElimination half-life6.2 hours1.00infobox
Folinic acidExcretionKidney1.00infobox
Folinic acidFormulaC20H23N7O71.00infobox
Folinic acidIUPHAR/BPS48161.00infobox
Folinic acidLegal statusUS: ℞-only1.00infobox
Folinic acidLicense dataUS DailyMed: Leucovorin calcium1.00infobox
Folinic acidMedlinePlusa6080381.00infobox
Folinic acidMelting point245 °C (473 °F) decomp1.00infobox
Folinic acidMolar mass473.446 g·mol−11.00infobox
Folinic acidOther namesLeucovorin, citrovorum factor, 5-formyltetrahydrofolate1.00infobox
Folinic acidPregnancy categoryAU: A1.00infobox
Folinic acidPronunciationLeucovorin /ˌljuːkoʊˈvɔːrɪn/1.00infobox
Folinic acidProtein binding~15%1.00infobox
Folinic acidPubChem CID1354036481.00infobox
Folinic acidRoutes of administrationBy mouth, intramuscular, intravenous1.00infobox
Folinic acidSolubility in water~0.3 mg/mL (20 °C)1.00infobox
Folinic acidUNIIRPR1R4C0P41.00infobox
Folinic acidis aform of folic acid that does not require activation by dihydrofolate reductase to be useful to the body.Folinic acid was first made in 19450.90text
Folinic acidis avitamer of folic acid and has the full vitamin activity of this vitamin0.90text

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