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FOXO3

Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene.

Clinical significance, Function & Overview

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Clinical significance

36 related topics

Function

11 related topics

Overview

2 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
FOXO3, AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A, forkhead box O3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2K86, 2LQH, 2LQI, 2UZK
Band
6q21 · 10 B2|10 22.79 cM
Bgee
secondary oocyte · trabecular bone · cerebellar vermis · nipple · middle temporal gyrus
BioGPS
More reference expression data
Chr.
Chromosome 6 (human) · Chromosome 10 (mouse)

Topics to explore

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Overview

Function

Clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

FOXO3

Nodes53
Edges52
Triples188
Avg. degree1.96
Density0.037736
Components1

How this topic connects Entity context

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FOXO3

Top relations

Gene ontology · 70
FOXO3 → ageing, anatomical structure morphogenesis, antral ovarian follicle growth, apoptotic process, beta-catenin binding, brain morphogenesis, cellular response to amyloid-beta, cellular response to corticosterone stimulus, cellular response to glucose stimulus, cellular response to hypoxia, cellular response to nerve growth factor stimulus, cellular response to oxidative stress, chromatin DNA binding, cytokine-mediated signaling pathway, cytoplasm, cytosol, DNA binding, DNA damage response, signal transduction by p53 class mediator, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity
Bgee · 19
FOXO3 → aortic valve, ascending aorta, blood, buccal mucosa cell, cerebellar vermis, ciliary body, cumulus cell, fetal liver hematopoietic progenitor cell, fossa, middle temporal gyrus, nipple, parietal pleura, pericardium, primary oocyte, secondary oocyte, tibialis anterior muscle, trabecular bone, visceral pleura, zygote
RNA expression pattern · 19
FOXO3 → aortic valve, ascending aorta, blood, buccal mucosa cell, cerebellar vermis, ciliary body, cumulus cell, fetal liver hematopoietic progenitor cell, fossa, middle temporal gyrus, nipple, parietal pleura, pericardium, primary oocyte, secondary oocyte, tibialis anterior muscle, trabecular bone, visceral pleura, zygote
related to Function · 12
FOXO3 → Akt/PKB, DNA-binding, FoxO, FOXO1, FOXO3a, FOXO4, FOXO6, Other, PI3K, The, There, These
related to Apoptosis · 10
FOXO3 → Also, Bim, Fellows, FLIP, FOXO3a, Further, MMP-13, PUMA, VSMCs, Yu
related to Clinical significance · 7
FOXO3 → Akt, Alternatively, Deregulation, Downregulation, FOXO3a, MLL, PTEN
related to External links · 7
FOXO3 → FOXO3A, Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
related to Stem cells · 6
FOXO3 → FOXO3a, Gopinath, It, MnSOD, Notch-dependent, Ron DePinho's
related to Association with intelligence · 5
FOXO3 → European, In, SNP, SNPs, Various
related to Longevity · 4
FOXO3 → Genetic, It, Mice, The

Important terminology Word statistics

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Important terminology

foxo3a human gene bp also chr band chromosome protein forkhead mice transcription activity location apoptosis longevity stem cells intelligence mouse

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
FOXO3AliasesFOXO3, AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A, forkhead box O31.00infobox
FOXO3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2K86, 2LQH, 2LQI, 2UZK1.00infobox
FOXO3Band6q211.00infobox
FOXO3Band10 B2|10 22.79 cM1.00infobox
FOXO3Bgeesecondary oocyte1.00infobox
FOXO3Bgeetrabecular bone1.00infobox
FOXO3Bgeecerebellar vermis1.00infobox
FOXO3Bgeenipple1.00infobox
FOXO3Bgeemiddle temporal gyrus1.00infobox
FOXO3Bgeevisceral pleura1.00infobox
FOXO3Bgeebuccal mucosa cell1.00infobox
FOXO3Bgeetibialis anterior muscle1.00infobox
FOXO3Bgeepericardium1.00infobox
FOXO3Bgeeparietal pleura1.00infobox
FOXO3Bgeezygote1.00infobox
FOXO3Bgeefetal liver hematopoietic progenitor cell1.00infobox
FOXO3Bgeeprimary oocyte1.00infobox
FOXO3Bgeeciliary body1.00infobox
FOXO3Bgeeaortic valve1.00infobox
FOXO3Bgeeascending aorta1.00infobox
FOXO3Bgeecumulus cell1.00infobox
FOXO3Bgeeblood1.00infobox
FOXO3Bgeefossa1.00infobox
FOXO3BioGPSMore reference expression data1.00infobox
FOXO3Chr.Chromosome 6 (human)1.00infobox
FOXO3Chr.Chromosome 10 (mouse)1.00infobox
FOXO3DatabasesNCBI: entry; OMA: entry1.00infobox
FOXO3End108,684,774 bp1.00infobox
FOXO3End42,152,751 bp1.00infobox
FOXO3EnsemblENSG000001186891.00infobox

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