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First pass effect

The first pass effect (FPE), also known as first-pass metabolism (FPM) or presystemic metabolism, is a phenomenon of drug metabolism at a specific location in the body which leads to a reduction in the concentration of the active drug before it reaches the site of action or systemic circulation. The effect is most associated with orally administered…

Mitigation, Overview & Hepatic first-pass

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Overview

Factors

Hepatic first-pass

Drug design

Mitigation

Advanced semantic analysis

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Map overview Semantic statistics

First pass effect

Nodes63
Edges62
Triples24
Avg. degree1.97
Density0.031746
Components1

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First pass effect

Top relations

related to External links · 17
First pass effect → Exposure Archived, FL, In, Influence, Internet, Jan, Medicine, National Library, PMID, Route, Santos, Sep, StatPearls, StatPearls Publishing, Toxicology Tutor II, Treasure Island, Wayback MachineHerman TF
related to Routes of administration · 5
First pass effect → Alternative, Bioavailability, Drugs, Oral, There
related to Factors · 2
First pass effect → First-pass, The

Important terminology Word statistics

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Important terminology

metabolism first-pass drug liver pass effect first drugs bioavailability also body active hepatic absorption propranolol may portal systemic circulation administered

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
First pass effectrelated to External linksNational Library0.60section
First pass effectrelated to External linksMedicine0.60section
First pass effectrelated to External linksToxicology Tutor II0.60section
First pass effectrelated to External linksInfluence0.60section
First pass effectrelated to External linksRoute0.60section
First pass effectrelated to External linksExposure Archived0.60section
First pass effectrelated to External linksWayback MachineHerman TF0.60section
First pass effectrelated to External linksSantos0.60section
First pass effectrelated to External linksSep0.60section
First pass effectrelated to External linksIn0.60section
First pass effectrelated to External linksStatPearls0.60section
First pass effectrelated to External linksInternet0.60section

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    Min side: 3
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