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Fibroblast growth factor 21 (FGF-21) is a protein found in humans and other mammals that is encoded by the FGF21 gene. This protein is a member of the fibroblast growth factor (FGF) family and its endocrine subfamily along with FGF23 and FGF15/19. FGF21 is the primary endogenous agonist of the FGF21 receptor, which is composed of the FGF receptor and…
The analysis highlights Research, Regulation and Function as prominent areas in the source structure around Fibroblast growth factor 21.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
A focused starting point derived from the topic graph, ranked independently of the source article order.
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The extracted context around Fibroblast growth factor 21 shows recurring relationship patterns in the source. For example, Fibroblast growth factor 21 → cell-cell signaling, cellular response to glucagon stimulus, cellular response to glucose stimulus, cellular response to low-density lipoprotein particle stimulus, endoplasmic reticulum unfolded protein response, endothelial cell apoptotic process, extracellular region, extracellular space, fibroblast growth factor receptor binding, fibroblast growth factor receptor signaling pathway, growth factor activity, negative regulation of endothelial cell apoptotic process, negative regulation of neuron death, positive regulation of cell population proliferation, positive regulation of cold-induced thermogenesis, positive regulation of ERK1 and ERK2 cascade, positive regulation of glucose import, positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway, positive regulation of triglyceride catabolic process, protein binding Another extracted example is Fibroblast growth factor 21 → axial skeleton, blood, calvaria, cornea, embryo, female breast, gastrocnemius muscle, head, islet of Langerhans, lactiferous gland, left lobe of liver, liver, mammary gland, mouth, muscle of thigh, pancreatic ductal cell, pyloric antrum, right lobe of liver, spermatid, thymus. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
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TTTA extracted 96 structured relationships around Fibroblast growth factor 21. Examples in this analysis include Fibroblast growth factor 21 → Aliases → FGF21, fibroblast growth factor 21 and Fibroblast growth factor 21 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5VAQ, 6M6F, 6M6E. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Fibroblast growth factor 21 | Aliases | FGF21, fibroblast growth factor 21 | 1.00 | infobox |
| Fibroblast growth factor 21 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5VAQ, 6M6F, 6M6E | 1.00 | infobox |
| Fibroblast growth factor 21 | Band | 19q13.33 | 1.00 | infobox |
| Fibroblast growth factor 21 | Band | 7|7 B3 | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | right lobe of liver | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | pancreatic ductal cell | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | muscle of thigh | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | female breast | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | mammary gland | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | lactiferous gland | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | gastrocnemius muscle | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | head | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | mouth | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | blood | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | pyloric antrum | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | embryo | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | thymus | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | calvaria | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | liver | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | islet of Langerhans | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | left lobe of liver | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | axial skeleton | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | cornea | 1.00 | infobox |
| Fibroblast growth factor 21 | Bgee | spermatid | 1.00 | infobox |
| Fibroblast growth factor 21 | BioGPS | More reference expression data | 1.00 | infobox |
| Fibroblast growth factor 21 | Chr. | Chromosome 19 (human) | 1.00 | infobox |
| Fibroblast growth factor 21 | Chr. | Chromosome 7 (mouse) | 1.00 | infobox |
| Fibroblast growth factor 21 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Fibroblast growth factor 21 | End | 48,758,333 bp | 1.00 | infobox |
| Fibroblast growth factor 21 | End | 45,264,914 bp | 1.00 | infobox |
The concept neighborhoods around Fibroblast growth factor 21 bring nearby vocabulary together. In this analysis, examples include Factor, Fibroblast and Growth. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Fibroblast growth factor 21, one of the stronger structural bridges in this analysis connects Fibroblast growth factor 21 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Fibroblast growth factor 21 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, Regulation & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Fibroblast growth factor 21 · EN edition · Analysis: TopicsToTalkAbout