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Fibroblast growth factor 21: Research, Regulation & Function

Fibroblast growth factor 21 (FGF-21) is a protein found in humans and other mammals that is encoded by the FGF21 gene. This protein is a member of the fibroblast growth factor (FGF) family and its endocrine subfamily along with FGF23 and FGF15/19. FGF21 is the primary endogenous agonist of the FGF21 receptor, which is composed of the FGF receptor and…

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Fibroblast growth factor 21 topic overview

The analysis highlights Research, Regulation and Function as prominent areas in the source structure around Fibroblast growth factor 21.

Related topics
56
Source areas
5
Connected nodes
61
Extracted relationships
96
Concept neighborhoods
19
Bridge connections
61

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 19 topics
Regulation · 15 topics
Function · 13 topics
Animal studies · 8 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
FGF21, fibroblast growth factor 21
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5VAQ, 6M6F, 6M6E
Band
19q13.33 · 7|7 B3
Bgee
right lobe of liver · pancreatic ductal cell · muscle of thigh · female breast · mammary gland
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 7 (mouse)

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Regulation

Function

Clinical significance

Animal studies

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Fibroblast growth factor 21 connects Entity context

The extracted context around Fibroblast growth factor 21 shows recurring relationship patterns in the source. For example, Fibroblast growth factor 21 → cell-cell signaling, cellular response to glucagon stimulus, cellular response to glucose stimulus, cellular response to low-density lipoprotein particle stimulus, endoplasmic reticulum unfolded protein response, endothelial cell apoptotic process, extracellular region, extracellular space, fibroblast growth factor receptor binding, fibroblast growth factor receptor signaling pathway, growth factor activity, negative regulation of endothelial cell apoptotic process, negative regulation of neuron death, positive regulation of cell population proliferation, positive regulation of cold-induced thermogenesis, positive regulation of ERK1 and ERK2 cascade, positive regulation of glucose import, positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway, positive regulation of triglyceride catabolic process, protein binding Another extracted example is Fibroblast growth factor 21 → axial skeleton, blood, calvaria, cornea, embryo, female breast, gastrocnemius muscle, head, islet of Langerhans, lactiferous gland, left lobe of liver, liver, mammary gland, mouth, muscle of thigh, pancreatic ductal cell, pyloric antrum, right lobe of liver, spermatid, thymus. Use these groups to spot repeated connection types before inspecting the individual relationships.

Fibroblast growth factor 21

Top relations

Gene ontology · 26
Fibroblast growth factor 21 → cell-cell signaling, cellular response to glucagon stimulus, cellular response to glucose stimulus, cellular response to low-density lipoprotein particle stimulus, endoplasmic reticulum unfolded protein response, endothelial cell apoptotic process, extracellular region, extracellular space, fibroblast growth factor receptor binding, fibroblast growth factor receptor signaling pathway, growth factor activity, negative regulation of endothelial cell apoptotic process, negative regulation of neuron death, positive regulation of cell population proliferation, positive regulation of cold-induced thermogenesis, positive regulation of ERK1 and ERK2 cascade, positive regulation of glucose import, positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway, positive regulation of triglyceride catabolic process, protein binding
Bgee · 20
Fibroblast growth factor 21 → axial skeleton, blood, calvaria, cornea, embryo, female breast, gastrocnemius muscle, head, islet of Langerhans, lactiferous gland, left lobe of liver, liver, mammary gland, mouth, muscle of thigh, pancreatic ductal cell, pyloric antrum, right lobe of liver, spermatid, thymus
RNA expression pattern · 20
Fibroblast growth factor 21 → axial skeleton, blood, calvaria, cornea, embryo, female breast, gastrocnemius muscle, head, islet of Langerhans, lactiferous gland, left lobe of liver, liver, mammary gland, mouth, muscle of thigh, pancreatic ductal cell, pyloric antrum, right lobe of liver, spermatid, thymus
Band · 2
Fibroblast growth factor 21 → 19q13.33, 7|7 B3
Chr. · 2
Fibroblast growth factor 21 → Chromosome 19 (human), Chromosome 7 (mouse)
End · 2
Fibroblast growth factor 21 → 45,264,914 bp, 48,758,333 bp
Aliases · 1
Fibroblast growth factor 21 → FGF21, fibroblast growth factor 21
Available structures · 1
Fibroblast growth factor 21 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5VAQ, 6M6F, 6M6E
BioGPS · 1
Fibroblast growth factor 21 → More reference expression data
Databases · 1
Fibroblast growth factor 21 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

fgf21 liver expression protein glucose levels gene growth fgf response factor receptor also mice induced including fibroblast bp regulation humans

Fibroblast growth factor 21 relationships Subject–Predicate–Object triples

TTTA extracted 96 structured relationships around Fibroblast growth factor 21. Examples in this analysis include Fibroblast growth factor 21 → Aliases → FGF21, fibroblast growth factor 21 and Fibroblast growth factor 21 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5VAQ, 6M6F, 6M6E. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Fibroblast growth factor 21AliasesFGF21, fibroblast growth factor 211.00infobox
Fibroblast growth factor 21Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5VAQ, 6M6F, 6M6E1.00infobox
Fibroblast growth factor 21Band19q13.331.00infobox
Fibroblast growth factor 21Band7|7 B31.00infobox
Fibroblast growth factor 21Bgeeright lobe of liver1.00infobox
Fibroblast growth factor 21Bgeepancreatic ductal cell1.00infobox
Fibroblast growth factor 21Bgeemuscle of thigh1.00infobox
Fibroblast growth factor 21Bgeefemale breast1.00infobox
Fibroblast growth factor 21Bgeemammary gland1.00infobox
Fibroblast growth factor 21Bgeelactiferous gland1.00infobox
Fibroblast growth factor 21Bgeegastrocnemius muscle1.00infobox
Fibroblast growth factor 21Bgeehead1.00infobox
Fibroblast growth factor 21Bgeemouth1.00infobox
Fibroblast growth factor 21Bgeeblood1.00infobox
Fibroblast growth factor 21Bgeepyloric antrum1.00infobox
Fibroblast growth factor 21Bgeeembryo1.00infobox
Fibroblast growth factor 21Bgeethymus1.00infobox
Fibroblast growth factor 21Bgeecalvaria1.00infobox
Fibroblast growth factor 21Bgeeliver1.00infobox
Fibroblast growth factor 21Bgeeislet of Langerhans1.00infobox
Fibroblast growth factor 21Bgeeleft lobe of liver1.00infobox
Fibroblast growth factor 21Bgeeaxial skeleton1.00infobox
Fibroblast growth factor 21Bgeecornea1.00infobox
Fibroblast growth factor 21Bgeespermatid1.00infobox
Fibroblast growth factor 21BioGPSMore reference expression data1.00infobox
Fibroblast growth factor 21Chr.Chromosome 19 (human)1.00infobox
Fibroblast growth factor 21Chr.Chromosome 7 (mouse)1.00infobox
Fibroblast growth factor 21DatabasesNCBI: entry; OMA: entry1.00infobox
Fibroblast growth factor 21End48,758,333 bp1.00infobox
Fibroblast growth factor 21End45,264,914 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Fibroblast growth factor 21 bring nearby vocabulary together. In this analysis, examples include Factor, Fibroblast and Growth. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Fibroblast growth factor 21
    • Factor
    • Fibroblast
    • Growth
    • Gene
    • Receptor
    • Human
    • Protein
    • Bp
    • Chr
    • Regulation
    • Band
    • Intake
  • fibroblast growth factor 21
    • Factor
    • Fibroblast
    • Growth
    • Gene
    • Receptor
    • Human
    • Protein
    • Bp
    • Chr
    • Intake
    • Regulation
    • Liver
  • fibroblast growth factor
    • Factor
    • Fibroblast
    • Growth
    • Gene
    • Receptor
    • Human
    • Protein
    • Bp
    • Chr
    • Intake
    • Regulation
    • Liver
  • fgf21 receptor
    • Binding
    • Expression
    • Liver
    • Β-klotho
    • Induced
    • Mice
    • Levels
    • Glucose
    • Also
    • Response
    • Protein
    • Consumption
  • gene
    • Human
    • Bp
    • Chr
    • Consumption
    • Humans
    • Growth
    • Band
    • Sugar
    • Sweet
    • Activity
    • Regulation
    • Mice
  • fgf receptor
    • Receptors
    • Binding
    • Β-klotho
    • Receptor
    • Protein
    • Band
    • Human
    • Intake
    • Liver
    • Signaling
    • Activity
    • Bp
  • glucose
    • Levels
    • Intake
    • Signaling
    • Also
    • Induced
    • Mice
    • Response
    • Protein
    • Expression
    • Band
    • Human
    • Insulin
  • peroxisome proliferator-activated receptor alpha
    • Binding
    • Β-klotho
    • Protein
    • Band
    • Human
    • Intake
    • Liver
    • Signaling
    • Activity
    • Bp
    • Chr
    • Energy

Connections between topic areas Semantic bridges

For Fibroblast growth factor 21, one of the stronger structural bridges in this analysis connects Fibroblast growth factor 21 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Fibroblast growth factor 21 — Overview · splits 42 ⟂ 20
Fibroblast growth factor 21 — Regulation · splits 46 ⟂ 16
Fibroblast growth factor 21 — Function · splits 48 ⟂ 14
Fibroblast growth factor 21 — Animal studies · splits 53 ⟂ 9

Map overview Semantic statistics

Fibroblast growth factor 21

Nodes62
Edges61
Triples96
Avg. degree1.97
Density0.032258
Components1

Source & methodology

TTTA analyzes the structure around Fibroblast growth factor 21 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, Regulation & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Fibroblast growth factor 21 · EN edition · Analysis: TopicsToTalkAbout

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