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Fibrillin-1 is a protein that in humans is encoded by the FBN1 gene, located on chromosome 15. It is a large, extracellular matrix glycoprotein that serves as a structural component of 10–12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body.…
The analysis highlights Clinical significance, Gene and Structure as prominent areas in the source structure around Fibrillin-1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Fibrillin-1 shows recurring relationship patterns in the source. For example, Fibrillin-1 → activation of protein kinase A activity, basement membrane, calcium ion binding, camera-type eye development, cell adhesion mediated by integrin, cellular response to insulin-like growth factor stimulus, cellular response to transforming growth factor beta stimulus, collagen-containing extracellular matrix, development of the heart, embryonic eye morphogenesis, endoplasmic reticulum lumen, extracellular exosome, extracellular matrix, extracellular matrix constituent conferring elasticity, extracellular matrix disassembly, extracellular matrix organization, extracellular matrix structural constituent, extracellular region, extracellular space, glucose homeostasis Another extracted example is Fibrillin-1 → Antagonism, Aortic, Clinical, EC, ECM, In, LAP, LLC, LTBP, LTBP1, MDS, MFS, Mutations, N-terminal, NAb, PAI-1, SLC, Smad2, TGF-β, The LLC. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
mfs tgf-β gene mutations elastic fbn1 protein aortic microfibrils development chromosome 15 structural symptoms bp marfan syndrome human skin chr
TTTA extracted 183 structured relationships around Fibrillin-1. Examples in this analysis include Fibrillin-1 → Aliases → FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2, MFLS, fibrillin 1 and Fibrillin-1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1APJ, 1EMN, 1EMO, 1LMJ, 1UZJ, 1UZK, 1UZP, 1UZQ, 2M74, 2W86. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Fibrillin-1 | Aliases | FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2, MFLS, fibrillin 1 | 1.00 | infobox |
| Fibrillin-1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1APJ, 1EMN, 1EMO, 1LMJ, 1UZJ, 1UZK, 1UZP, 1UZQ, 2M74, 2W86 | 1.00 | infobox |
| Fibrillin-1 | Band | 15q21.1 | 1.00 | infobox |
| Fibrillin-1 | Band | 2 F1|2 61.38 cM | 1.00 | infobox |
| Fibrillin-1 | Bgee | synovial joint | 1.00 | infobox |
| Fibrillin-1 | Bgee | skin of hip | 1.00 | infobox |
| Fibrillin-1 | Bgee | decidua | 1.00 | infobox |
| Fibrillin-1 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| Fibrillin-1 | Bgee | vulva | 1.00 | infobox |
| Fibrillin-1 | Bgee | pericardium | 1.00 | infobox |
| Fibrillin-1 | Bgee | periodontal fiber | 1.00 | infobox |
| Fibrillin-1 | Bgee | vena cava | 1.00 | infobox |
| Fibrillin-1 | Bgee | parietal pleura | 1.00 | infobox |
| Fibrillin-1 | Bgee | saphenous vein | 1.00 | infobox |
| Fibrillin-1 | Bgee | external carotid artery | 1.00 | infobox |
| Fibrillin-1 | Bgee | ascending aorta | 1.00 | infobox |
| Fibrillin-1 | Bgee | umbilical cord | 1.00 | infobox |
| Fibrillin-1 | Bgee | semi-lunar valve | 1.00 | infobox |
| Fibrillin-1 | Bgee | aortic valve | 1.00 | infobox |
| Fibrillin-1 | Bgee | gastrula | 1.00 | infobox |
| Fibrillin-1 | Bgee | internal carotid artery | 1.00 | infobox |
| Fibrillin-1 | Bgee | ciliary body | 1.00 | infobox |
| Fibrillin-1 | Bgee | dermis | 1.00 | infobox |
| Fibrillin-1 | Bgee | efferent ductule | 1.00 | infobox |
| Fibrillin-1 | BioGPS | More reference expression data | 1.00 | infobox |
| Fibrillin-1 | Chr. | Chromosome 15 (human) | 1.00 | infobox |
| Fibrillin-1 | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| Fibrillin-1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Fibrillin-1 | End | 48,645,721 bp | 1.00 | infobox |
| Fibrillin-1 | End | 125,349,913 bp | 1.00 | infobox |
The concept neighborhoods around Fibrillin-1 bring nearby vocabulary together. In this analysis, examples include Elastic, Protein and Development. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Fibrillin-1, one of the stronger structural bridges in this analysis connects Fibrillin-1 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Fibrillin-1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Gene & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Fibrillin-1 · EN edition · Analysis: TopicsToTalkAbout