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Fibrillin-1: Clinical significance, Gene & Structure

Fibrillin-1 is a protein that in humans is encoded by the FBN1 gene, located on chromosome 15. It is a large, extracellular matrix glycoprotein that serves as a structural component of 10–12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body.…

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Fibrillin-1 topic overview

The analysis highlights Clinical significance, Gene and Structure as prominent areas in the source structure around Fibrillin-1.

Related topics
30
Source areas
4
Connected nodes
34
Extracted relationships
183
Concept neighborhoods
14
Bridge connections
34

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 14 topics
Overview · 8 topics
Gene · 5 topics
Structure · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2, MFLS, fibrillin 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1APJ, 1EMN, 1EMO, 1LMJ, 1UZJ, 1UZK, 1UZP, 1UZQ, 2M74, 2W86
Band
15q21.1 · 2 F1|2 61.38 cM
Bgee
synovial joint · skin of hip · decidua · stromal cell of endometrium · vulva
BioGPS
More reference expression data
Chr.
Chromosome 15 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Structure

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Fibrillin-1 connects Entity context

The extracted context around Fibrillin-1 shows recurring relationship patterns in the source. For example, Fibrillin-1 → activation of protein kinase A activity, basement membrane, calcium ion binding, camera-type eye development, cell adhesion mediated by integrin, cellular response to insulin-like growth factor stimulus, cellular response to transforming growth factor beta stimulus, collagen-containing extracellular matrix, development of the heart, embryonic eye morphogenesis, endoplasmic reticulum lumen, extracellular exosome, extracellular matrix, extracellular matrix constituent conferring elasticity, extracellular matrix disassembly, extracellular matrix organization, extracellular matrix structural constituent, extracellular region, extracellular space, glucose homeostasis Another extracted example is Fibrillin-1 → Antagonism, Aortic, Clinical, EC, ECM, In, LAP, LLC, LTBP, LTBP1, MDS, MFS, Mutations, N-terminal, NAb, PAI-1, SLC, Smad2, TGF-β, The LLC. Use these groups to spot repeated connection types before inspecting the individual relationships.

Fibrillin-1

Top relations

Gene ontology · 42
Fibrillin-1 → activation of protein kinase A activity, basement membrane, calcium ion binding, camera-type eye development, cell adhesion mediated by integrin, cellular response to insulin-like growth factor stimulus, cellular response to transforming growth factor beta stimulus, collagen-containing extracellular matrix, development of the heart, embryonic eye morphogenesis, endoplasmic reticulum lumen, extracellular exosome, extracellular matrix, extracellular matrix constituent conferring elasticity, extracellular matrix disassembly, extracellular matrix organization, extracellular matrix structural constituent, extracellular region, extracellular space, glucose homeostasis
related to Role of TGF-β · 23
Fibrillin-1 → Antagonism, Aortic, Clinical, EC, ECM, In, LAP, LLC, LTBP, LTBP1, MDS, MFS, Mutations, N-terminal, NAb, PAI-1, SLC, Smad2, TGF-β, The LLC
Bgee · 20
Fibrillin-1 → aortic valve, ascending aorta, ciliary body, decidua, dermis, efferent ductule, external carotid artery, gastrula, internal carotid artery, parietal pleura, pericardium, periodontal fiber, saphenous vein, semi-lunar valve, skin of hip, stromal cell of endometrium, synovial joint, umbilical cord, vena cava, vulva
RNA expression pattern · 20
Fibrillin-1 → aortic valve, ascending aorta, ciliary body, decidua, dermis, efferent ductule, external carotid artery, gastrula, internal carotid artery, parietal pleura, pericardium, periodontal fiber, saphenous vein, semi-lunar valve, skin of hip, stromal cell of endometrium, synovial joint, umbilical cord, vena cava, vulva
related to Fetal cardiovascular development · 10
Fibrillin-1 → FBN-1, FBN-2, It, Marfan, The, The FBN-1, These, This, When, While
related to Mutations · 7
Fibrillin-1 → EGF, Elastogenesis, FBN1, MFS, Polymerised, These, This
related to External links · 6
Fibrillin-1 → GeneReviews/NCBI/NIH/UW, Marfan SyndromeOverview, P35555, PDB, PDBe-KB, UniProt
is a · 3
Fibrillin-1 → 350-kDa, large cysteine rich-glycoprotein approximately 350 kDa mainly composed of tandemly repeating domains of epidermal growth factor, protein that in humans is encoded by the FBN1 gene
related to Structure · 3
Fibrillin-1 → EGF-like, TGF-beta, The
Band · 2
Fibrillin-1 → 15q21.1, 2 F1|2 61.38 cM

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

mfs tgf-β gene mutations elastic fbn1 protein aortic microfibrils development chromosome 15 structural symptoms bp marfan syndrome human skin chr

Fibrillin-1 relationships Subject–Predicate–Object triples

TTTA extracted 183 structured relationships around Fibrillin-1. Examples in this analysis include Fibrillin-1 → Aliases → FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2, MFLS, fibrillin 1 and Fibrillin-1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1APJ, 1EMN, 1EMO, 1LMJ, 1UZJ, 1UZK, 1UZP, 1UZQ, 2M74, 2W86. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Fibrillin-1AliasesFBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2, MFLS, fibrillin 11.00infobox
Fibrillin-1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1APJ, 1EMN, 1EMO, 1LMJ, 1UZJ, 1UZK, 1UZP, 1UZQ, 2M74, 2W861.00infobox
Fibrillin-1Band15q21.11.00infobox
Fibrillin-1Band2 F1|2 61.38 cM1.00infobox
Fibrillin-1Bgeesynovial joint1.00infobox
Fibrillin-1Bgeeskin of hip1.00infobox
Fibrillin-1Bgeedecidua1.00infobox
Fibrillin-1Bgeestromal cell of endometrium1.00infobox
Fibrillin-1Bgeevulva1.00infobox
Fibrillin-1Bgeepericardium1.00infobox
Fibrillin-1Bgeeperiodontal fiber1.00infobox
Fibrillin-1Bgeevena cava1.00infobox
Fibrillin-1Bgeeparietal pleura1.00infobox
Fibrillin-1Bgeesaphenous vein1.00infobox
Fibrillin-1Bgeeexternal carotid artery1.00infobox
Fibrillin-1Bgeeascending aorta1.00infobox
Fibrillin-1Bgeeumbilical cord1.00infobox
Fibrillin-1Bgeesemi-lunar valve1.00infobox
Fibrillin-1Bgeeaortic valve1.00infobox
Fibrillin-1Bgeegastrula1.00infobox
Fibrillin-1Bgeeinternal carotid artery1.00infobox
Fibrillin-1Bgeeciliary body1.00infobox
Fibrillin-1Bgeedermis1.00infobox
Fibrillin-1Bgeeefferent ductule1.00infobox
Fibrillin-1BioGPSMore reference expression data1.00infobox
Fibrillin-1Chr.Chromosome 15 (human)1.00infobox
Fibrillin-1Chr.Chromosome 2 (mouse)1.00infobox
Fibrillin-1DatabasesNCBI: entry; OMA: entry1.00infobox
Fibrillin-1End48,645,721 bp1.00infobox
Fibrillin-1End125,349,913 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Fibrillin-1 bring nearby vocabulary together. In this analysis, examples include Elastic, Protein and Development. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Fibrillin-1
    • Elastic
    • Protein
    • Development
    • Microfibrils
    • Binding
    • Gene
    • Chromosome
    • Structural
    • Mutations
    • Fbn1
    • Tgf-β
    • Extracellular
  • fibrillin-1
    • Elastic
    • Protein
    • Development
    • Microfibrils
    • Binding
    • Gene
    • Chromosome
    • Structural
    • Mutations
    • Fbn1
    • Tgf-β
    • Extracellular
  • gene
    • Human
    • Bp
    • Chr
    • Fbn-1
    • Marfan
    • Syndrome
    • Mutations
    • Protein
    • Band
    • Embryonic
    • Mfs
    • Development
  • chromosome 15
    • Bp
    • Chr
    • Human
    • Fbn1
    • Band
    • Gene
    • Development
    • Protein
    • Fibrillin-1
    • Extracellular
    • Activation
    • Aorta
  • extracellular matrix
    • Matrix
    • Structural
    • Band
    • Activation
    • Aorta
    • Bp
    • Chr
    • Complex
    • Embryonic
    • Human
    • Valve
    • Binding
  • latent tgf-beta binding protein
    • Complex
    • Binding
    • Protein
    • Associated
    • Embryonic
    • Tgf-β
    • Fibrillin-1
    • Extracellular
    • Activation
    • Bp
    • Chr
    • Human
  • protein
    • Binding
    • Complex
    • Embryonic
    • Tgf-β
    • Band
    • Activation
    • Aorta
    • Bp
    • Chr
    • Human
    • Valve
    • System
  • marfan syndrome
    • Syndrome
    • Associated
    • Mutations
    • Bp
    • Chr
    • Human
    • Also
    • Fbn-1
    • System
    • Valves
    • Skin
    • Structural

Connections between topic areas Semantic bridges

For Fibrillin-1, one of the stronger structural bridges in this analysis connects Fibrillin-1 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Fibrillin-1Clinical significance · splits 20 ⟂ 15
Fibrillin-1Overview · splits 26 ⟂ 9
Fibrillin-1Gene · splits 29 ⟂ 6
Fibrillin-1Structure · splits 31 ⟂ 4

Map overview Semantic statistics

Fibrillin-1

Nodes35
Edges34
Triples183
Avg. degree1.94
Density0.057143
Components1

Source & methodology

TTTA analyzes the structure around Fibrillin-1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Gene & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Fibrillin-1 · EN edition · Analysis: TopicsToTalkAbout

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