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Fibrillin-1 is a protein that in humans is encoded by the FBN1 gene, located on chromosome 15. It is a large, extracellular matrix glycoprotein that serves as a structural component of 10–12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body.…
Clinical significance, Gene & Structure
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mfs tgf-β gene mutations elastic fbn1 protein aortic microfibrils development chromosome 15 structural symptoms bp marfan syndrome human skin chr
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Fibrillin-1 | Aliases | FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2, MFLS, fibrillin 1 | 1.00 | infobox |
| Fibrillin-1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1APJ, 1EMN, 1EMO, 1LMJ, 1UZJ, 1UZK, 1UZP, 1UZQ, 2M74, 2W86 | 1.00 | infobox |
| Fibrillin-1 | Band | 15q21.1 | 1.00 | infobox |
| Fibrillin-1 | Band | 2 F1|2 61.38 cM | 1.00 | infobox |
| Fibrillin-1 | Bgee | synovial joint | 1.00 | infobox |
| Fibrillin-1 | Bgee | skin of hip | 1.00 | infobox |
| Fibrillin-1 | Bgee | decidua | 1.00 | infobox |
| Fibrillin-1 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| Fibrillin-1 | Bgee | vulva | 1.00 | infobox |
| Fibrillin-1 | Bgee | pericardium | 1.00 | infobox |
| Fibrillin-1 | Bgee | periodontal fiber | 1.00 | infobox |
| Fibrillin-1 | Bgee | vena cava | 1.00 | infobox |
| Fibrillin-1 | Bgee | parietal pleura | 1.00 | infobox |
| Fibrillin-1 | Bgee | saphenous vein | 1.00 | infobox |
| Fibrillin-1 | Bgee | external carotid artery | 1.00 | infobox |
| Fibrillin-1 | Bgee | ascending aorta | 1.00 | infobox |
| Fibrillin-1 | Bgee | umbilical cord | 1.00 | infobox |
| Fibrillin-1 | Bgee | semi-lunar valve | 1.00 | infobox |
| Fibrillin-1 | Bgee | aortic valve | 1.00 | infobox |
| Fibrillin-1 | Bgee | gastrula | 1.00 | infobox |
| Fibrillin-1 | Bgee | internal carotid artery | 1.00 | infobox |
| Fibrillin-1 | Bgee | ciliary body | 1.00 | infobox |
| Fibrillin-1 | Bgee | dermis | 1.00 | infobox |
| Fibrillin-1 | Bgee | efferent ductule | 1.00 | infobox |
| Fibrillin-1 | BioGPS | More reference expression data | 1.00 | infobox |
| Fibrillin-1 | Chr. | Chromosome 15 (human) | 1.00 | infobox |
| Fibrillin-1 | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| Fibrillin-1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Fibrillin-1 | End | 48,645,721 bp | 1.00 | infobox |
| Fibrillin-1 | End | 125,349,913 bp | 1.00 | infobox |
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