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Asprosin: Function, Profibrillin cleavage and asprosin secretion & Therapeutic potential
Asprosin is a fasting-induced hormone encoded by the FBN1 gene and derived from the cleavage of the fibrillin-1 protein, a structural component of the extracellular matrix. It is primarily produced and secreted by white adipose tissue. As a peripherally derived hormone, asprosin actively crosses the blood-brain barrier (BBB) to exert central effects on…
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Asprosin topic overview
The analysis highlights Function, Profibrillin cleavage and asprosin secretion and Therapeutic potential as prominent areas in the source structure around Asprosin.
Related topics
33
Source areas
6
Connected nodes
39
Extracted relationships
107
Concept neighborhoods
16
Bridge connections
39
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Function · 12 topics
Profibrillin cleavage and asprosin secretion · 10 topics
Therapeutic potential · 5 topics
Clinical significance · 4 topics
Classification · 1 topics
Discovery · 1 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Domains
InterPro
HGNC
3603
Locus
Chr. 15 q21.1
NCBI gene
2200
OMIM
134797
RefSeq
NP_000129
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How Asprosin connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around Asprosin shows recurring relationship patterns in the source. For example, Asprosin → Additionally, AgRP, Altogether, Asprosin's, CSF, In, It, POMC, PTPRD, Ptprd-dependent, Ptprf, Purkinje, Researchers, Science Advances, SK, SK3, The, This, Whole Another extracted example is Asprosin → Akt, AMP, Between, G6pc, Glycogenolysis, GPCR, However, In, LAR, Mechanistically, Nevertheless, Olfr734, OR4M1, Pck1, PTPRF, Ptprf-deficient, Several, The. Use these groups to spot repeated connection types before inspecting the individual relationships.
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 107 structured relationships around Asprosin. Examples in this analysis include Asprosin → Domains → InterPro and Asprosin → HGNC → 3603. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
Asprosin
Domains
InterPro
1.00
infobox
Asprosin
HGNC
3603
1.00
infobox
Asprosin
Locus
Chr. 15 q21.1
1.00
infobox
Asprosin
NCBI gene
2200
1.00
infobox
Asprosin
OMIM
134797
1.00
infobox
Asprosin
RefSeq
NP_000129
1.00
infobox
Asprosin
Search for
Search forStructuresSwiss-modelDomainsInterPro
1.00
infobox
Asprosin
Structures
Swiss-model
1.00
infobox
Asprosin
Symbol
FBN1
1.00
infobox
Asprosin
UniProt
P35555
1.00
infobox
Asprosin
is a
fasting-induced hormone encoded by the FBN1 gene and derived from the cleavage of the fibrillin-1 protein
0.90
text
obesity
instance of
Dysregulation of asprosin levels has been implicated in metabolic disorders
0.80
text
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around Asprosin bring nearby vocabulary together. In this analysis, examples include Levels, Effects and Obesity. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Asprosin
Levels
Effects
Obesity
Glucose
Mice
Neurons
Plasma
Weight
Protein
Study
Appetite
Agrp
asprosin
Levels
Effects
Obesity
Glucose
Mice
Neurons
Plasma
Weight
Protein
Study
Appetite
Agrp
profibrillin cleavage and asprosin secretion
Fibrillin-1
Protein
Gene
Cleavage
Levels
Secretion
Fbn1
Hormone
Effects
Obesity
Glucose
Mice
fibrillin-1
Gene
Protein
Secretion
Syndrome
Patients
Production
Reduced
Two
Function
Hepatic
Hormone
Effects
blood–brain barrier
Function
Liver
Reduced
Release
Role
Expressed
Ptprd
Mice
Neurons
Syndrome
Weight
Levels
function
Glucogenic
Brain
Ptprd
Asprosin's
Also
Gene
Glucose
Orexigenic
Release
Secretion
Hepatic
Liver
insulin
Patients
Levels
Release
Role
Two
Mice
Liver
Obesity
Plasma
Syndrome
Study
agrp
Neurons
Appetite
Ptprd
Body
Effects
Weight
Asprosin
Orexigenic
Reduced
Obesity
Study
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For Asprosin, one of the stronger structural bridges in this analysis connects Asprosin with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
Asprosin
Nodes40
Edges39
Triples107
Avg. degree1.95
Density0.05
Components1
Source & methodology
TTTA analyzes the structure around Asprosin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Profibrillin cleavage and asprosin secretion & Therapeutic potential, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
