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Asprosin

Asprosin is a fasting-induced hormone encoded by the FBN1 gene and derived from the cleavage of the fibrillin-1 protein, a structural component of the extracellular matrix. It is primarily produced and secreted by white adipose tissue. As a peripherally derived hormone, asprosin actively crosses the blood-brain barrier (BBB) to exert central effects on…

Function, Profibrillin cleavage and asprosin secretion & Therapeutic potential

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Key facts & relationships

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Domains
InterPro
HGNC
3603
Locus
Chr. 15 q21.1
NCBI gene
2200
OMIM
134797
RefSeq
NP_000129

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Discovery

Profibrillin cleavage and asprosin secretion

Function

Classification

Clinical significance

Therapeutic potential

Advanced semantic analysis

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Map overview Semantic statistics

Asprosin

Nodes40
Edges39
Triples107
Avg. degree1.95
Density0.05
Components1

How this topic connects Entity context

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Asprosin

Top relations

related to Central Function · 19
Asprosin → Additionally, AgRP, Altogether, Asprosin's, CSF, In, It, POMC, PTPRD, Ptprd-dependent, Ptprf, Purkinje, Researchers, Science Advances, SK, SK3, The, This, Whole
related to Hepatic Function · 18
Asprosin → Akt, AMP, Between, G6pc, Glycogenolysis, GPCR, However, In, LAR, Mechanistically, Nevertheless, Olfr734, OR4M1, Pck1, PTPRF, Ptprf-deficient, Several, The
related to Profibrillin cleavage and asprosin secretion · 15
Asprosin → C-terminal, Evidence, FBN1, Furin, Golgi, However, It, MIN6, R-C-K/R-R, Since, The, There, This, While, While FBN1
related to Discovery · 13
Asprosin → Atul Chopra, Baylor College, Chopra, Dr, FBN1, Marfanoid, Medicine, MPL, NPS, The, These, This, To
related to Classification · 6
Asprosin → C-terminal, It, Latin, Members, The, Therefore
related to Fibrillin-1 · 6
Asprosin → FBN1, Fibrillin-1, Individuals, Marfan, Marfanoid, MPL
related to Asprosin · 4
Asprosin → Asprosin-induced, Obese, Obesity, Patients
related to Monoclonal anti-asprosin antibody · 3
Asprosin → Mishra, Specifically, These
related to Therapeutic potential · 3
Asprosin → Chopra, For, In
Domains · 1
Asprosin → InterPro

Important terminology Word statistics

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Important terminology

glucose appetite levels obesity fibrillin-1 protein study effects liver weight neurons metabolic cleavage syndrome also plasma body hormone ptprd fbn1

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
AsprosinDomainsInterPro1.00infobox
AsprosinHGNC36031.00infobox
AsprosinLocusChr. 15 q21.11.00infobox
AsprosinNCBI gene22001.00infobox
AsprosinOMIM1347971.00infobox
AsprosinRefSeqNP_0001291.00infobox
AsprosinSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
AsprosinStructuresSwiss-model1.00infobox
AsprosinSymbolFBN11.00infobox
AsprosinUniProtP355551.00infobox
Asprosinis afasting-induced hormone encoded by the FBN1 gene and derived from the cleavage of the fibrillin-1 protein0.90text
obesityinstance ofDysregulation of asprosin levels has been implicated in metabolic disorders0.80text

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