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FCGR2B

Fc fragment of IgG receptor IIb (coded by FCGR2B gene) is a low affinity inhibitory receptor for the Fc region of immunoglobulin gamma (IgG). FCGR2B participates in the phagocytosis of immune complexes and in the regulation of antibody production by B lymphocytes.

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Aliases
FCGR2B, CD32, CD32B, FCG2, FCGR2, IGFR2, Fc fragment of IgG receptor IIb, FcRII-c, FCGR2C
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2FCB, 3WJJ,%%s3WJL
Band
1q23.3 · 1 H3|1 78.02 cM
Bgee
placenta · right coronary artery · blood · spleen · monocyte
BioGPS
n/a
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

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Structure

Function

Autoimmunity

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Map overview Semantic statistics

FCGR2B

Nodes39
Edges38
Triples164
Avg. degree1.95
Density0.051282
Components1

How this topic connects Entity context

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FCGR2B

Top relations

Gene ontology · 61
FCGR2B → amyloid-beta binding, antigen processing and presentation of exogenous peptide antigen via MHC class II, cell body, cellular response to amyloid-beta, cellular response to molecule of bacterial origin, cerebellum development, cytoplasm, defense response, dendritic spine, external side of plasma membrane, Fc-gamma receptor signaling pathway involved in phagocytosis, follicular B cell differentiation, follicular dendritic cell activation, IgG binding, immune complex clearance by monocytes and macrophages, immune response, immunoglobulin mediated immune response, inflammatory response, integral component of membrane, integral component of plasma membrane
Bgee · 17
FCGR2B → appendix, blood, calvaria, granulocyte, lymph node, molar, monocyte, motor neuron, placenta, right coronary artery, right kidney, skin of abdomen, spleen, stroma of bone marrow, synovial joint, synovial membrane, tibiofemoral joint
RNA expression pattern · 17
FCGR2B → appendix, blood, calvaria, granulocyte, lymph node, molar, monocyte, motor neuron, placenta, right coronary artery, right kidney, skin of abdomen, spleen, stroma of bone marrow, synovial joint, synovial membrane, tibiofemoral joint
related to Function · 16
FCGR2B → Akt, BCR, FCGR, FcγRIIB, FcγRs, However, Inhibition, ITIM, MAP, MAPK, PKC, PLCγ, Ras, SHIP1, SHIP2, The
related to Structure · 13
FCGR2B → Both, C1, CD32, FCGR2A, FCGR2B1, FCGR2B2, FCGR2C, FcγR, Immunoreceptor Tyrosine-based Inhibitory Motif, It, ITIM, The, There
related to Expression · 9
FCGR2B → C5a, Cytokine, FCGR2B1, FCGR2B2, FCGRA, IFN-γ, IL-10, IL-6, TNF-α
related to External links · 6
FCGR2B → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
Band · 2
FCGR2B → 1 H3|1 78.02 cM, 1q23.3
Chr. · 2
FCGR2B → Chromosome 1 (human), Chromosome 1 (mouse)
End · 2
FCGR2B → 161,678,654 bp, 170,804,116 bp

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Important terminology

cells immune fcγriib bp human complexes receptor chr band activation bcr gene chromosome dendritic igg expression function inhibitory antibody phagocytosis

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
FCGR2BAliasesFCGR2B, CD32, CD32B, FCG2, FCGR2, IGFR2, Fc fragment of IgG receptor IIb, FcRII-c, FCGR2C1.00infobox
FCGR2BAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2FCB, 3WJJ,%%s3WJL1.00infobox
FCGR2BBand1q23.31.00infobox
FCGR2BBand1 H3|1 78.02 cM1.00infobox
FCGR2BBgeeplacenta1.00infobox
FCGR2BBgeeright coronary artery1.00infobox
FCGR2BBgeeblood1.00infobox
FCGR2BBgeespleen1.00infobox
FCGR2BBgeemonocyte1.00infobox
FCGR2BBgeelymph node1.00infobox
FCGR2BBgeesynovial membrane1.00infobox
FCGR2BBgeesynovial joint1.00infobox
FCGR2BBgeegranulocyte1.00infobox
FCGR2BBgeeappendix1.00infobox
FCGR2BBgeestroma of bone marrow1.00infobox
FCGR2BBgeetibiofemoral joint1.00infobox
FCGR2BBgeecalvaria1.00infobox
FCGR2BBgeeskin of abdomen1.00infobox
FCGR2BBgeeright kidney1.00infobox
FCGR2BBgeemolar1.00infobox
FCGR2BBgeemotor neuron1.00infobox
FCGR2BBioGPSn/a1.00infobox
FCGR2BChr.Chromosome 1 (human)1.00infobox
FCGR2BChr.Chromosome 1 (mouse)1.00infobox
FCGR2BDatabasesNCBI: entry; OMA: entry1.00infobox
FCGR2BEnd161,678,654 bp1.00infobox
FCGR2BEnd170,804,116 bp1.00infobox
FCGR2BEnsemblENSG000000726941.00infobox
FCGR2BEntrez22131.00infobox
FCGR2BExternal IDsOMIM: 604590; MGI: 95499; GeneCards: FCGR2B1.00infobox

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