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Dystonin: Standards, Interactions & Loss of function in neurological disease

Dystonin (DST), also known as bullous pemphigoid antigen 1 (BPAG1), isoforms 1/2/3/4/5/8, is a protein that in humans is encoded by the DST gene.

Language: English [EN]
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Dystonin topic overview

The analysis highlights Standards, Interactions and Loss of function in neurological disease as prominent areas in the source structure around Dystonin.

Related topics
15
Source areas
3
Connected nodes
18
Extracted relationships
99
Concept neighborhoods
14
Bridge connections
18

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 8 topics
Interactions · 5 topics
Loss of function in neurological disease · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
DST, BPA, BPAG1, CATX-15, CATX15, D6S1101, DMH, DT, EBSB2, HSAN6, MACF2, dystonin, BP230, BP240, EBS3
Available structures
Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes3GJO
Band
6p12.1
Bgee
corpus callosum · Achilles tendon · internal globus pallidus · pars reticulata · inferior olivary nucleus
BioGPS
More reference expression data
Chr.
Chromosome 6 (human)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Interactions

Loss of function in neurological disease

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Dystonin connects Entity context

The extracted context around Dystonin shows recurring relationship patterns in the source. For example, Dystonin → actin binding, actin cytoskeleton, axon, axon cytoplasm, basal plasma membrane, basement membrane, calcium ion binding, cell adhesion, cell cortex, cell junction, cell leading edge, cell motility, cell projection, cytoplasm, cytoplasmic microtubule organization, cytoplasmic vesicle, cytoskeletal protein binding, cytoskeleton, cytoskeleton organization, cytosol Another extracted example is Dystonin → Achilles tendon, body of uterus, corpus callosum, external globus pallidus, inferior ganglion of vagus nerve, inferior olivary nucleus, internal globus pallidus, pars compacta, pars reticulata, subthalamic nucleus. Use these groups to spot repeated connection types before inspecting the individual relationships.

Dystonin

Top relations

Gene ontology · 53
Dystonin → actin binding, actin cytoskeleton, axon, axon cytoplasm, basal plasma membrane, basement membrane, calcium ion binding, cell adhesion, cell cortex, cell junction, cell leading edge, cell motility, cell projection, cytoplasm, cytoplasmic microtubule organization, cytoplasmic vesicle, cytoskeletal protein binding, cytoskeleton, cytoskeleton organization, cytosol
Bgee · 10
Dystonin → Achilles tendon, body of uterus, corpus callosum, external globus pallidus, inferior ganglion of vagus nerve, inferior olivary nucleus, internal globus pallidus, pars compacta, pars reticulata, subthalamic nucleus
RNA expression pattern · 10
Dystonin → Achilles tendon, body of uterus, corpus callosum, external globus pallidus, inferior ganglion of vagus nerve, inferior olivary nucleus, internal globus pallidus, pars compacta, pars reticulata, subthalamic nucleus
related to Loss of function in neurological disease · 4
Dystonin → Charcot-Marie-Tooth, In, Several Dst, VI
related to Interactions · 3
Dystonin → DCTN1, MAP1B, XVII
Aliases · 1
Dystonin → DST, BPA, BPAG1, CATX-15, CATX15, D6S1101, DMH, DT, EBSB2, HSAN6, MACF2, dystonin, BP230, BP240, EBS3
Available structures · 1
Dystonin → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes3GJO
Band · 1
Dystonin → 6p12.1
BioGPS · 1
Dystonin → More reference expression data
Chr. · 1
Dystonin → Chromosome 6 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene protein dst human isoforms bp chr chromosome function cytoskeleton known actin loss also uniprot band bpag1 adhesion junction expressed

Dystonin relationships Subject–Predicate–Object triples

TTTA extracted 99 structured relationships around Dystonin. Examples in this analysis include Dystonin → Aliases → DST, BPA, BPAG1, CATX-15, CATX15, D6S1101, DMH, DT, EBSB2, HSAN6, MACF2, dystonin, BP230, BP240, EBS3 and Dystonin → Available structures → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes3GJO. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DystoninAliasesDST, BPA, BPAG1, CATX-15, CATX15, D6S1101, DMH, DT, EBSB2, HSAN6, MACF2, dystonin, BP230, BP240, EBS31.00infobox
DystoninAvailable structuresAvailable structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes3GJO1.00infobox
DystoninBand6p12.11.00infobox
DystoninBgeecorpus callosum1.00infobox
DystoninBgeeAchilles tendon1.00infobox
DystoninBgeeinternal globus pallidus1.00infobox
DystoninBgeepars reticulata1.00infobox
DystoninBgeeinferior olivary nucleus1.00infobox
DystoninBgeepars compacta1.00infobox
DystoninBgeeexternal globus pallidus1.00infobox
DystoninBgeesubthalamic nucleus1.00infobox
DystoninBgeeinferior ganglion of vagus nerve1.00infobox
DystoninBgeebody of uterus1.00infobox
DystoninBioGPSMore reference expression data1.00infobox
DystoninChr.Chromosome 6 (human)1.00infobox
DystoninDatabasesNCBI: entry; OMA: entry1.00infobox
DystoninEnd56,954,830 bp1.00infobox
DystoninEnsemblENSG000001519141.00infobox
DystoninEntrez6671.00infobox
DystoninExternal IDsOMIM: 113810; GeneCards: DST1.00infobox
DystoninGene location (Human)Gene location (Human)Chr.Chromosome 6 (human)Band6p12.1Start56,457,987 bpEnd56,954,830 bp1.00infobox
DystoninGene ontologycalcium ion binding1.00infobox
DystoninGene ontologyprotein homodimerization activity1.00infobox
DystoninGene ontologymicrotubule plus-end binding1.00infobox
DystoninGene ontologymetal ion binding1.00infobox
DystoninGene ontologyintegrin binding1.00infobox
DystoninGene ontologyprotein C-terminus binding1.00infobox
DystoninGene ontologyprotein binding1.00infobox
DystoninGene ontologyactin binding1.00infobox
DystoninGene ontologymicrotubule binding1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Dystonin bring nearby vocabulary together. In this analysis, examples include Function, Axonal and Bpag1. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Dystonin
    • Function
    • Axonal
    • Bpag1
    • Disease
    • External
    • Humans
    • Location
    • Search
    • Type
    • Uniprot
    • Gene
    • Bp
  • dystonin
    • Function
    • Axonal
    • Bpag1
    • Disease
    • External
    • Humans
    • Location
    • Search
    • Type
    • Uniprot
    • Gene
    • Bp
  • gene
    • Protein
    • Adhesion
    • Expression
    • External
    • Junction
    • Location
    • Search
    • Uniprot
    • Bp
    • Chr
    • Chromosome
    • Function
  • actin
    • Cytoskeleton
    • Expressed
    • Intermediate
    • Hemidesmosomes
    • Adhesion
    • Axonal
    • Band
    • Expression
    • External
    • Junction
    • Known
    • Location
  • cytoskeleton
    • Expressed
    • Intermediate
    • Hemidesmosomes
    • Axonal
    • Band
    • Expression
    • External
    • Junction
    • Known
    • Location
    • Mouse
    • Search
  • loss of function in neurological disease
    • Axonal
    • Disease
    • External
    • Function
    • Location
    • Loss
    • Search
    • Type
    • Uniprot
    • Bp
    • Chr
    • Chromosome
  • intermediate filaments
    • Actin
    • Cytoskeleton
    • Hemidesmosomes
    • Axonal
    • Band
    • Expression
    • External
    • Junction
    • Known
    • Location
    • Mouse
    • Search
  • charcot-marie-tooth disease
    • Function
    • Loss
    • Dystonin
    • Axonal
    • External
    • Humans
    • Location
    • Search
    • Sensory
    • Type
    • Uniprot
    • Bp

Connections between topic areas Semantic bridges

For Dystonin, one of the stronger structural bridges in this analysis connects Dystonin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DystoninOverview · splits 10 ⟂ 9
DystoninInteractions · splits 13 ⟂ 6
DystoninLoss of function in neurological disease · splits 16 ⟂ 3

Map overview Semantic statistics

Dystonin

Nodes19
Edges18
Triples99
Avg. degree1.89
Density0.105263
Components1

Source & methodology

TTTA analyzes the structure around Dystonin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Interactions & Loss of function in neurological disease, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Dystonin · EN edition · Analysis: TopicsToTalkAbout

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