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EIF4A

The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA.

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Alt. symbols
EIF4A
Domains
InterPro
HGNC
3282
Locus
Chr. 17 p13
NCBI gene
1973
OMIM
602641

Topics to explore

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Overview

Background

Function

Mechanism

Proteins

Advanced semantic analysis

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Map overview Semantic statistics

EIF4A

Nodes40
Edges39
Triples45
Avg. degree1.95
Density0.05
Components1

How this topic connects Entity context

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EIF4A

Top relations

related to Mechanism · 10
EIF4A → ADP, ATP, ATP-dependent RNA, AUG, Bi, For, Once, The, Together, UTR
related to Proteins · 10
EIF4A → Carruthers, Crystallographic, D-E-A-D, DEAD, II, III, RNA, The, This, Three
related to Function · 7
EIF4A → Before, Binding, Eukaryotic, GTP, In, Met-tRNA, UTR
related to Genes · 5
EIF4A → EIF4A1, II, III, In, The
is a · 2
EIF4A → abundant cytoplasmic protein.Three isoforms, prototypical member of the DEAD box helicase family
Alt. symbols · 1
EIF4A → EIF4A
Domains · 1
EIF4A → InterPro
HGNC · 1
EIF4A → 3282
Locus · 1
EIF4A → Chr. 17 p13
NCBI gene · 1
EIF4A → 1973

Important terminology Word statistics

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Important terminology

initiation translation proteins eukaryotic eif4f mrna binding eif4a1 rna complex factors 17 ribosomal protein 5’ family paralogs function p13 40s

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
EIF4AAlt. symbolsEIF4A1.00infobox
EIF4ADomainsInterPro1.00infobox
EIF4AHGNC32821.00infobox
EIF4ALocusChr. 17 p131.00infobox
EIF4ANCBI gene19731.00infobox
EIF4AOMIM6026411.00infobox
EIF4ARefSeqNM_0014161.00infobox
EIF4ASearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
EIF4AStructuresSwiss-model1.00infobox
EIF4ASymbolEIF4A11.00infobox
EIF4AUniProtP608421.00infobox
EIF4Ais aprototypical member of the DEAD box helicase family0.90text
EIF4Ais aabundant cytoplasmic protein.Three isoforms0.90text

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