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EIF4A: Measurement, Function & Background

The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA.

Language: English [EN]
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EIF4A topic overview

The analysis highlights Measurement, Function and Background as prominent areas in the source structure around EIF4A.

Related topics
34
Source areas
5
Connected nodes
39
Extracted relationships
45
Concept neighborhoods
19
Bridge connections
39

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 9 topics
Overview · 9 topics
Background · 7 topics
Mechanism · 6 topics
Proteins · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Alt. symbols
EIF4A
Domains
InterPro
HGNC
3282
Locus
Chr. 17 p13
NCBI gene
1973
OMIM
602641

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Background

Function

Mechanism

Proteins

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How EIF4A connects Entity context

The extracted context around EIF4A shows recurring relationship patterns in the source. For example, EIF4A → ADP, ATP, ATP-dependent RNA, AUG, Bi, For, Once, The, Together, UTR Another extracted example is EIF4A → Carruthers, Crystallographic, D-E-A-D, DEAD, II, III, RNA, The, This, Three. Use these groups to spot repeated connection types before inspecting the individual relationships.

EIF4A

Top relations

related to Mechanism · 10
EIF4A → ADP, ATP, ATP-dependent RNA, AUG, Bi, For, Once, The, Together, UTR
related to Proteins · 10
EIF4A → Carruthers, Crystallographic, D-E-A-D, DEAD, II, III, RNA, The, This, Three
related to Function · 7
EIF4A → Before, Binding, Eukaryotic, GTP, In, Met-tRNA, UTR
related to Genes · 5
EIF4A → EIF4A1, II, III, In, The
is a · 2
EIF4A → abundant cytoplasmic protein.Three isoforms, prototypical member of the DEAD box helicase family
Alt. symbols · 1
EIF4A → EIF4A
Domains · 1
EIF4A → InterPro
HGNC · 1
EIF4A → 3282
Locus · 1
EIF4A → Chr. 17 p13
NCBI gene · 1
EIF4A → 1973

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

initiation translation proteins eukaryotic eif4f mrna binding eif4a1 rna complex factors 17 ribosomal protein 5’ family paralogs function p13 40s

EIF4A relationships Subject–Predicate–Object triples

TTTA extracted 45 structured relationships around EIF4A. Examples in this analysis include EIF4A → Alt. symbols → EIF4A and EIF4A → Domains → InterPro. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
EIF4AAlt. symbolsEIF4A1.00infobox
EIF4ADomainsInterPro1.00infobox
EIF4AHGNC32821.00infobox
EIF4ALocusChr. 17 p131.00infobox
EIF4ANCBI gene19731.00infobox
EIF4AOMIM6026411.00infobox
EIF4ARefSeqNM_0014161.00infobox
EIF4ASearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
EIF4AStructuresSwiss-model1.00infobox
EIF4ASymbolEIF4A11.00infobox
EIF4AUniProtP608421.00infobox
EIF4Ais aprototypical member of the DEAD box helicase family0.90text
EIF4Ais aabundant cytoplasmic protein.Three isoforms0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around EIF4A bring nearby vocabulary together. In this analysis, examples include Kda, Binding and Eif4f. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • EIF4A
    • Kda
    • Binding
    • Eif4f
    • Also
    • Eif4a1
    • Family
    • Paralogs
    • Secondary
    • Structure
    • Protein
    • Complex
    • Mrna
  • eif4a
    • Kda
    • Binding
    • Eif4f
    • Also
    • Eif4a1
    • Family
    • Paralogs
    • Secondary
    • Structure
    • Protein
    • Complex
    • Mrna
  • eukaryotic cells
    • Initiation
    • Translation
    • Factor
    • Eif4f
    • Consists
    • Family
    • Involved
    • Range
    • Factors
    • Binding
    • Complex
    • Eif4a
  • ternary complex
    • 5’
    • Translation
    • Mrna
    • Eukaryotic
    • P13
    • Eif4a
    • Factor
    • Gene
    • Involved
    • Kda
    • Number
    • Paralogs
  • mrna
    • Ribosomal
    • Secondary
    • Structure
    • 5’
    • Translation
    • Complex
    • Eif4f
    • Addition
    • Unwind
    • Elongation
    • Factor
    • Involved
  • eif4f
    • Factor
    • Eukaryotic
    • Initiation
    • Mrna
    • Translation
    • Unwind
    • Humans
    • Involved
    • Paralogs
    • Ribosomal
    • Secondary
    • Structure
  • rna
    • Translation
    • Unwind
    • Elongation
    • Humans
    • Kda
    • Range
    • Ribosomal
    • Secondary
    • Structure
    • Synthesis
    • 5’
    • Protein
  • mature messenger rna
    • Translation
    • Unwind
    • Elongation
    • Humans
    • Kda
    • Range
    • Ribosomal
    • Secondary
    • Structure
    • Synthesis
    • 5’
    • Protein

Connections between topic areas Semantic bridges

For EIF4A, one of the stronger structural bridges in this analysis connects EIF4A with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
EIF4A — Overview · splits 30 ⟂ 10
EIF4A — Function · splits 30 ⟂ 10
EIF4A — Background · splits 32 ⟂ 8
EIF4A — Mechanism · splits 33 ⟂ 7
EIF4A — Proteins · splits 36 ⟂ 4

Map overview Semantic statistics

EIF4A

Nodes40
Edges39
Triples45
Avg. degree1.95
Density0.05
Components1

Source & methodology

TTTA analyzes the structure around EIF4A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Function & Background, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — EIF4A · EN edition · Analysis: TopicsToTalkAbout

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