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EIF2

Eukaryotic Initiation Factor 2 (eIF2) is a eukaryotic initiation factor. It is required for most forms of eukaryotic translation initiation. eIF2 mediates the binding of tRNAiMet to the ribosome in a GTP-dependent manner. eIF2 is a heterotrimer consisting of an alpha (also called subunit 1, EIF2S1), a beta (subunit 2, EIF2S2), and a gamma (subunit 3…

Measurement, Function & Structure

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Regulation

Disease

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EIF2

Nodes47
Edges46
Triples70
Avg. degree1.96
Density0.042553
Components1

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EIF2

Top relations

related to Regulation · 19
EIF2 → As, ER, Furthermore, GCN2, GCN4, GDP, GEF, GTP, GTP-bound, However, HRI, Once, PERK, Phosphorylated, Phosphorylation, PKR, Since, Those, Without
related to Disease · 16
EIF2 → Alzheimer's, For, GEF, However, Huntington's, It, Mutations, Parkinson's, PKR, Potentially, Since, The, There, Therefore, Vanishing White Matter, VWM
related to Function · 16
EIF2 → After, AUG, AUG-codon, Finally, GAP, GDP, GEF, GTP, GTPase-activating, Met-tRNA, Met-tRNAiMet, PIC, TC, The, This, Upon
related to Structure · 7
EIF2 → Homo, It, RNA, S1, Saccharomyces, The, Therefore
see also · 7
EIF2 → EIF2AK1PKR, Eukaryotic, GCN2, Heme-regulated, PERK, PKR-like ER-localized, Protein
is a · 1
EIF2 → heterotrimer consisting of an alpha

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Important terminology

initiation complex translation eif2b gtp also gdp protein factor phosphorylation ternary 43s gef subunit eukaryotic disease pic factors guanine exchange

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
EIF2is aheterotrimer consisting of an alpha0.90text
amino acid deprivationinstance ofThose kinases act as a result of stress0.80text
Alzheimer'sinstance ofeIF2 were found in patients with neurodegenerative diseases0.80text
Parkinson'sinstance ofeIF2 were found in patients with neurodegenerative diseases0.80text
and Huntington's diseaseinstance ofeIF2 were found in patients with neurodegenerative diseases0.80text
EIF2related to DiseaseSince0.60section
EIF2related to DiseaseThe0.60section
EIF2related to DiseaseTherefore0.60section
EIF2related to DiseaseHowever0.60section
EIF2related to DiseaseFor0.60section
EIF2related to DiseasePKR0.60section
EIF2related to DiseaseAlzheimer's0.60section

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