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Custirsen: Mechanism of action, Side effects & Pharmacokinetics

Custirsen (also known as OGX-011 and CC-8490), usually supplied as its sodium salt, is an investigational drug that is under clinical testing for the treatment of cancer. It is an antisense oligonucleotide (ASO) targeting clusterin expression. In metastatic prostate cancer, custirsen showed no benefit in improving overall survival.

Language: English [EN]

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Custirsen topic overview

The analysis highlights Mechanism of action, Side effects and Pharmacokinetics as prominent areas in the source structure around Custirsen.

Related topics: 39
Source areas: 4
Connected nodes: 43
Extracted relationships: 29
Concept neighborhoods: 8
Bridge connections: 43

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Mechanism of action · 19 topics

Side effects · 11 topics

Pharmacokinetics · 5 topics

Overview · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

CAS Number: 890056-27-6
ChemSpider: 34983386
DrugBank: DB05487
Formula: C231H312N78O119P20S20
Molar mass: 7346.14 g·mol−1
Other names: OGX-011, CC-8490

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Sodium
Antisense oligonucleotide Oligonucleotide
Clusterin
Teva Pharmaceutical Industries

Mechanism of action

Antisense oligonucleotide
Complementary Complementary DNA
Messenger RNA
Antisense therapy
Translation Translation (biology)
Phosphorothioate Phosphorothioate nucleic acid
Chirality Chirality (chemistry)
Nucleases Nuclease
Affinity Affinity (pharmacology)
2'-methoxyethyl Diglyme
Half-life
Upregulation Downregulation and upregulation
Apoptosis
Chemotherapy
Androgen deprivation therapy
Radiation therapy
Pro-apoptotic BLC2 gene Bcl-2
NF-KB NF-κB
Epithelial-mesenchymal transition

Pharmacokinetics

Meta-analysis study Meta-analysis
Intravenously Intravenous therapy
Pharmacokinetics
Clearance Clearance (pharmacology)
Volume of the Second Peripheral Compartment Volume of distribution

Side effects

Recurrent or refractory high-grade gliomas Glioma
Prostatectomy
Thrombocytopenia
Anaemia Anemia
Leukopenia
Alopecia Hair loss
Anorexia Anorexia nervosa
Dyspnea
Pleural effusion
Neutropenia
Mucositis

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Custirsen connects Entity context

The extracted context around Custirsen shows recurring relationship patterns in the source. For example, Custirsen → An, Antisense, ASO, DNA, Phosphorothioates, RNA, Second-generation, The, They, This Another extracted example is Custirsen → Contrasting, Custirsen-independent, Docetaxel, Phase III, Prednisone, Researchers, The Phase III SYNERGY. Use these groups to spot repeated connection types before inspecting the individual relationships.

Custirsen

Top relations

related to Mechanism of action · 10

Custirsen → An, Antisense, ASO, DNA, Phosphorothioates, RNA, Second-generation, The, They, This

related to Phase III Studies · 7

Custirsen → Contrasting, Custirsen-independent, Docetaxel, Phase III, Prednisone, Researchers, The Phase III SYNERGY

has effect · 2

Custirsen → Phase, The

related to Pharmacokinetics · 2

Custirsen → Subjects, The

CAS Number · 1

Custirsen → 890056-27-6

ChemSpider · 1

Custirsen → 34983386

DrugBank · 1

Custirsen → DB05487

Formula · 1

Custirsen → C231H312N78O119P20S20

Molar mass · 1

Custirsen → 7346.14 g·mol−1

Other names · 1

Custirsen → OGX-011, CC-8490

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

clusterin cancer drug mg studies dose antisense prostate phase study 640 also treatment mrna gene plasma protein increased patients found

Custirsen relationships Subject–Predicate–Object triples

TTTA extracted 29 structured relationships around Custirsen. Examples in this analysis include Custirsen → CAS Number → 890056-27-6 and Custirsen → ChemSpider → 34983386. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Custirsen	CAS Number	890056-27-6	1.00	infobox
Custirsen	ChemSpider	34983386	1.00	infobox
Custirsen	DrugBank	DB05487	1.00	infobox
Custirsen	Formula	C231H312N78O119P20S20	1.00	infobox
Custirsen	Molar mass	7346.14 g·mol−1	1.00	infobox
Custirsen	Other names	OGX-011, CC-8490	1.00	infobox
Custirsen	UNII	L26E95NLRK	1.00	infobox
Custirsen	is a	second-generation phosphorothioate antisense oligonucleotide	0.90	text
Custirsen	has effect	The	0.60	section
Custirsen	has effect	Phase	0.60	section
Custirsen	related to Mechanism of action	An	0.60	section
Custirsen	related to Mechanism of action	ASO	0.60	section

Related concept clusters Concept neighborhoods

The concept neighborhoods around Custirsen bring nearby vocabulary together. In this analysis, examples include Phase, Studies and Clusterin. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Custirsen
- Phase
- Studies
- Clusterin
- Patients
- Treatment
- Prostate
- Dose
- Cancer
- Mg
- Iii
- Plasma
- Study
custirsen
- Phase
- Studies
- Clusterin
- Patients
- Treatment
- Prostate
- Dose
- Cancer
- Mg
- Iii
- Plasma
- Study
clusterin
- Concentrations
- Plasma
- Prostate
- Custirsen
- Activity
- Adverse
- Binding
- Tumours
- Gene
- Patients
- Protein
- Phase
antisense oligonucleotide
- Aso
- Oligonucleotide
- Mrna
- Sequence
- Cc-8490
- Ogx-011
- Activity
- Binding
- Iii
- Oligonucleotides
- Phase
- Gene
antisense therapy
- Aso
- Oligonucleotide
- Mrna
- Cc-8490
- Ogx-011
- Activity
- Binding
- Iii
- Oligonucleotides
- Sequence
- Gene
- Increased
meta-analysis study
- Studies
- Clinical
- Mg
- Dose
- Custirsen
- Activity
- Binding
- Concentrations
- Including
- Found
- Patients
- Plasma
chemotherapy
- Iii
- Treatment
- Phase
- Including
- Increased
- Patients
- Prostate
- Dose
- Studies
- Mg
- Custirsen
- Clusterin
pro-apoptotic blc2 gene
- Binding
- Concentrations
- Increased
- Mrna
- Protein
- Adverse
- Including
- Oligonucleotides
- Sequence
- Tumours
- Plasma
- Prostate

Connections between topic areas Semantic bridges

For Custirsen, one of the stronger structural bridges in this analysis connects Custirsen with Mechanism of action. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Custirsen — Mechanism of action · splits 24 ⟂ 20

Custirsen — Side effects · splits 32 ⟂ 12

Custirsen — Pharmacokinetics · splits 38 ⟂ 6

Custirsen — Overview · splits 39 ⟂ 5

Map overview Semantic statistics

Custirsen

Nodes44

Edges43

Triples29

Avg. degree1.95

Density0.045455

Components1

Source & methodology

TTTA analyzes the structure around Custirsen to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Mechanism of action, Side effects & Pharmacokinetics, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Custirsen · EN edition · Analysis: TopicsToTalkAbout

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