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XPO1

Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.

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Explore the main themes, entities and connections around XPO1. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Interactions

11 related topics

History

5 related topics

Medical relevance

7 related topics

Overview

1 related topics

Key facts & relationships

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Aliases
XPO1, CRM1, emb, exp1, exportin 1, CRM-1
Available structures
Available structuresPDBOrtholog search: C9JV99 PDBe C9JV99 RCSB List of PDB id codes1W9C, 2L1L, 3GB8, 4BSM, 4BSN, 5DIS
Band
2p15 · 11|11 A3.2
Bgee
tibia · ventricular zone · germinal epithelium · epithelium of nasopharynx · parietal pleura
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 11 (mouse)

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Overview

History

Medical relevance

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

XPO1

Nodes29
Edges28
Triples126
Avg. degree1.93
Density0.068966
Components1

How this topic connects Entity context

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XPO1

Top relations

Gene ontology · 41
XPO1 → Cajal body, cytoplasm, cytosol, host cell, intracellular anatomical structure, intracellular membrane-bounded organelle, intracellular protein transport, intracellular transport of virus, kinetochore, lamellae anulatae, membrane, mRNA transport, negative regulation of transcription by RNA polymerase II, nuclear envelope, nuclear export signal receptor activity, nuclear membrane, nucleocytoplasmic transport, nucleolus, nucleoplasm, nucleus
Bgee · 20
XPO1 → abdominal wall, dermis, embryo, epiblast, epithelium of nasopharynx, genital tubercle, germinal epithelium, Gonadal ridge, human fetus, mandibular prominence, medullary collecting duct, palpebral conjunctiva, parietal pleura, primitive streak, skin of hip, tail of embryo, tibia, trabecular bone, ventricular zone, visceral pleura
RNA expression pattern · 20
XPO1 → abdominal wall, dermis, embryo, epiblast, epithelium of nasopharynx, genital tubercle, germinal epithelium, Gonadal ridge, human fetus, mandibular prominence, medullary collecting duct, palpebral conjunctiva, parietal pleura, primitive streak, skin of hip, tail of embryo, tibia, trabecular bone, ventricular zone, visceral pleura
related to Interactions · 9
XPO1 → APC, CDKN1B, CIITA, NMD3, Nucleoporin, Ran, RANBP1, RANBP3, SMARCB1
related to history · 5
XPO1 → CRM1, It, NES, Schizosaccharomyces, The
related to Medical relevance · 5
XPO1 → FDA, For, HIV-1 RNA, Rev, Selinexor
related to Function · 3
XPO1 → It, NES-dependent, RNAs
Band · 2
XPO1 → 11|11 A3.2, 2p15
Chr. · 2
XPO1 → Chromosome 11 (mouse), Chromosome 2 (human)
End · 2
XPO1 → 23,248,249 bp, 61,538,741 bp

Important terminology Word statistics

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Important terminology

bp export nuclear chr human band chromosome crm1 protein gene transport location various also mouse ribosomal viral exportin function external

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
XPO1AliasesXPO1, CRM1, emb, exp1, exportin 1, CRM-11.00infobox
XPO1Available structuresAvailable structuresPDBOrtholog search: C9JV99 PDBe C9JV99 RCSB List of PDB id codes1W9C, 2L1L, 3GB8, 4BSM, 4BSN, 5DIS1.00infobox
XPO1Band2p151.00infobox
XPO1Band11|11 A3.21.00infobox
XPO1Bgeetibia1.00infobox
XPO1Bgeeventricular zone1.00infobox
XPO1Bgeegerminal epithelium1.00infobox
XPO1Bgeeepithelium of nasopharynx1.00infobox
XPO1Bgeeparietal pleura1.00infobox
XPO1Bgeevisceral pleura1.00infobox
XPO1Bgeeembryo1.00infobox
XPO1Bgeeskin of hip1.00infobox
XPO1Bgeetrabecular bone1.00infobox
XPO1Bgeepalpebral conjunctiva1.00infobox
XPO1Bgeetail of embryo1.00infobox
XPO1Bgeeprimitive streak1.00infobox
XPO1Bgeegenital tubercle1.00infobox
XPO1BgeeGonadal ridge1.00infobox
XPO1Bgeedermis1.00infobox
XPO1Bgeeabdominal wall1.00infobox
XPO1Bgeeepiblast1.00infobox
XPO1Bgeehuman fetus1.00infobox
XPO1Bgeemandibular prominence1.00infobox
XPO1Bgeemedullary collecting duct1.00infobox
XPO1BioGPSMore reference expression data1.00infobox
XPO1Chr.Chromosome 2 (human)1.00infobox
XPO1Chr.Chromosome 11 (mouse)1.00infobox
XPO1DatabasesNCBI: entry; OMA: entry1.00infobox
XPO1End61,538,741 bp1.00infobox
XPO1End23,248,249 bp1.00infobox

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