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Cingulin: Regions, Function & Structure & interactions

Cingulin (CGN; from the Latin cingere "to form a belt around") is a cytosolic protein encoded by the CGN gene in humans localized at tight junctions (TJs) of vertebrate epithelial and endothelial cells.

Language: English [EN]
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Cingulin topic overview

The analysis highlights Regions, Function and Structure & interactions as prominent areas in the source structure around Cingulin.

Related topics
22
Source areas
4
Connected nodes
26
Extracted relationships
119
Concept neighborhoods
11
Bridge connections
26

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 10 topics
Structure & interactions · 7 topics
Overview · 3 topics
Discovery · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CGN, cingulin
Band
1q21.3 · 3 F2.1|3 40.74 cM
Bgee
pancreatic ductal cell · mucosa of ileum · mucosa of transverse colon · right uterine tube · body of pancreas
BioGPS
n/a
Chr.
Chromosome 1 (human) · Chromosome 3 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Structure & interactions

Function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Cingulin connects Entity context

The extracted context around Cingulin shows recurring relationship patterns in the source. For example, Cingulin → body of pancreas, ciliary body, duodenum, ileum, jejunum, mucosa of ileum, mucosa of transverse colon, otolith organ, pancreatic ductal cell, rectum, right lobe of liver, right lung, right uterine tube, secondary oocyte, transitional epithelium of urinary bladder, upper lobe of left lung, utricle, vestibular membrane of cochlear duct, yolk sac, zygote Another extracted example is Cingulin → C-terminal, GEF-H1, However, II, In, JAM-A, Moreover, Most, N-terminal, N-terminal ZO-1, RhoA, The, This, TJ, ZIM, ZO-1, ZO-2, ZO-3. Use these groups to spot repeated connection types before inspecting the individual relationships.

Cingulin

Top relations

Bgee · 20
Cingulin → body of pancreas, ciliary body, duodenum, ileum, jejunum, mucosa of ileum, mucosa of transverse colon, otolith organ, pancreatic ductal cell, rectum, right lobe of liver, right lung, right uterine tube, secondary oocyte, transitional epithelium of urinary bladder, upper lobe of left lung, utricle, vestibular membrane of cochlear duct, yolk sac, zygote
RNA expression pattern · 20
Cingulin → body of pancreas, ciliary body, duodenum, ileum, jejunum, mucosa of ileum, mucosa of transverse colon, otolith organ, pancreatic ductal cell, rectum, right lobe of liver, right lung, right uterine tube, secondary oocyte, transitional epithelium of urinary bladder, upper lobe of left lung, utricle, vestibular membrane of cochlear duct, yolk sac, zygote
related to Structure & interactions · 18
Cingulin → C-terminal, GEF-H1, However, II, In, JAM-A, Moreover, Most, N-terminal, N-terminal ZO-1, RhoA, The, This, TJ, ZIM, ZO-1, ZO-2, ZO-3
related to Function · 17
Cingulin → Changes, Embryoid, Furthermore, GATA4, In, In Xenopus, KD, KO, MDCK, Regarding, RhoA-dependent, The, Through, TJ, Together, ZO-1, ZO-3
Gene ontology · 10
Cingulin → actin binding, bicellular tight junction, biological process, cadherin binding, cell junction, cytoskeletal motor activity, myosin complex, plasma membrane, protein binding, transforming growth factor beta receptor signaling pathway
related to Discovery · 7
Cingulin → Cambridge, Dr, II, Molecular Biology, MRC Laboratory, Sandra Citi, UK
related to Human diseases · 4
Cingulin → Although, Furthermore, KO, RhoA
related to Homologs · 3
Cingulin → CGNL1, In, JACOP
Band · 2
Cingulin → 1q21.3, 3 F2.1|3 40.74 cM
Chr. · 2
Cingulin → Chromosome 1 (human), Chromosome 3 (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

human protein bp gene expression tight chr band cells mouse junctions chromosome cgn location function head also localized epithelial paracingulin

Cingulin relationships Subject–Predicate–Object triples

TTTA extracted 119 structured relationships around Cingulin. Examples in this analysis include Cingulin → Aliases → CGN, cingulin and Cingulin → Band → 1q21.3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CingulinAliasesCGN, cingulin1.00infobox
CingulinBand1q21.31.00infobox
CingulinBand3 F2.1|3 40.74 cM1.00infobox
CingulinBgeepancreatic ductal cell1.00infobox
CingulinBgeemucosa of ileum1.00infobox
CingulinBgeemucosa of transverse colon1.00infobox
CingulinBgeeright uterine tube1.00infobox
CingulinBgeebody of pancreas1.00infobox
CingulinBgeerectum1.00infobox
CingulinBgeeright lobe of liver1.00infobox
CingulinBgeeduodenum1.00infobox
CingulinBgeeupper lobe of left lung1.00infobox
CingulinBgeeright lung1.00infobox
CingulinBgeeotolith organ1.00infobox
CingulinBgeeutricle1.00infobox
CingulinBgeeyolk sac1.00infobox
CingulinBgeejejunum1.00infobox
CingulinBgeeciliary body1.00infobox
CingulinBgeezygote1.00infobox
CingulinBgeevestibular membrane of cochlear duct1.00infobox
CingulinBgeeileum1.00infobox
CingulinBgeesecondary oocyte1.00infobox
CingulinBgeetransitional epithelium of urinary bladder1.00infobox
CingulinBioGPSn/a1.00infobox
CingulinChr.Chromosome 1 (human)1.00infobox
CingulinChr.Chromosome 3 (mouse)1.00infobox
CingulinDatabasesNCBI: entry; OMA: entry1.00infobox
CingulinEnd151,538,692 bp1.00infobox
CingulinEnd94,693,826 bp1.00infobox
CingulinEnsemblENSG000001433751.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Cingulin bring nearby vocabulary together. In this analysis, examples include Protein, Expression and Tight. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Cingulin
    • Protein
    • Expression
    • Tight
    • Also
    • Head
    • Gene
    • Junctions
    • Mouse
    • Cells
    • Human
    • Claudin-2
    • Early
  • cingulin
    • Protein
    • Expression
    • Tight
    • Also
    • Head
    • Gene
    • Junctions
    • Mouse
    • Cells
    • Human
    • Claudin-2
    • Early
  • protein
    • Tight
    • Junction
    • Junctions
    • Epithelial
    • Interactions
    • Myosin
    • Also
    • Head
    • Expression
    • End
    • Claudin-2
    • Domain
  • membrane protein
    • Tight
    • Junction
    • Junctions
    • Epithelial
    • Interactions
    • Myosin
    • Also
    • Head
    • Expression
    • End
    • Claudin-2
    • Domain
  • gene
    • Location
    • Human
    • Chromosome
    • Bp
    • Chr
    • End
    • Function
    • Band
    • Mouse
    • Tight
    • Expression
    • Protein
  • function
    • Location
    • Chromosome
    • Bp
    • Chr
    • Gene
    • Human
    • End
    • Interactions
    • Junction
    • Myosin
    • Studied
    • Band
  • tight junctions
    • Tight
    • Epithelial
    • Localized
    • Stage
    • Protein
    • Claudin-2
    • Embryos
    • Junction
    • Maternal
    • Myosin
    • Zo-1
    • Expression
  • structure & interactions
    • Head
    • Protein
    • Domain
    • Location
    • N-terminal
    • Region
    • Also
    • Chromosome
    • Bp
    • Chr

Connections between topic areas Semantic bridges

For Cingulin, one of the stronger structural bridges in this analysis connects Cingulin with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CingulinFunction · splits 16 ⟂ 11
CingulinStructure & interactions · splits 19 ⟂ 8
CingulinOverview · splits 23 ⟂ 4
CingulinDiscovery · splits 24 ⟂ 3

Map overview Semantic statistics

Cingulin

Nodes27
Edges26
Triples119
Avg. degree1.93
Density0.074074
Components1

Source & methodology

TTTA analyzes the structure around Cingulin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Function & Structure & interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Cingulin · EN edition · Analysis: TopicsToTalkAbout

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