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Occludin

Occludin is a transmembrane protein that regulates the permeability of epithelial and endothelial barriers. It was first identified in epithelial cells as a 65 kDa integral plasma-membrane protein localized at the tight junctions. Together with Claudins, and zonula occludens-1 (ZO-1), occludin has been considered a staple of tight junctions, and although…

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Interactions

4 related topics

Gene location

2 related topics

Protein structure

1 related topics

Role in cancer

1 related topics

Key facts & relationships

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Aliases
OCLN, BLCPMG, PPP1R115, occludin, PTORCH1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1WPA, 1XAW, 3G7C
Band
5q13.2 · 13 D1|13 53.23 cM
Bgee
islet of Langerhans · mucosa of ileum · pancreatic ductal cell · right lobe of thyroid gland · body of pancreas
BioGPS
n/a
Chr.
Chromosome 5 (human) · Chromosome 13 (mouse)

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Overview

Gene location

Protein structure

Role in cancer

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

Occludin

Nodes17
Edges16
Triples122
Avg. degree1.88
Density0.117647
Components1

How this topic connects Entity context

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Occludin

Top relations

Bgee · 20
Occludin → body of pancreas, choroid plexus of fourth ventricle, duodenum, gonad, ileum, islet of Langerhans, jejunum, left colon, left lobe of thyroid gland, left lung lobe, migratory enteric neural crest cell, mucosa of ileum, pancreatic ductal cell, rectum, right lobe of thyroid gland, right lung, right lung lobe, seminal vesicula, stomach, sural nerve
RNA expression pattern · 20
Occludin → body of pancreas, choroid plexus of fourth ventricle, duodenum, gonad, ileum, islet of Langerhans, jejunum, left colon, left lobe of thyroid gland, left lung lobe, migratory enteric neural crest cell, mucosa of ileum, pancreatic ductal cell, rectum, right lobe of thyroid gland, right lung, right lung lobe, seminal vesicula, stomach, sural nerve
Gene ontology · 19
Occludin → apical plasma membrane, apicolateral plasma membrane, bicellular tight junction, bicellular tight junction assembly, cell junction, cell-cell junction, cell-cell junction organization, cellular response to tumor necrosis factor, cytoplasmic vesicle, endocytic vesicle, integral component of membrane, lateral plasma membrane, membrane, plasma membrane, protein binding, protein domain specific binding, protein-containing complex assembly, regulation of bicellular tight junction assembly, response to interleukin-18
related to Role in cancer · 11
Occludin → Furthermore, In, Loss, OCLN, Raf1-induced, Specifically, Still, Studies, The, The C-terminus, Thus
related to External links · 10
Occludin → Band-Like Calcification, Focus, GeneTests/NCBI/NIH/UW, Net, Polymicrogyria, Retrieved, Simplified Gyration, Tight Junction Overview, Vivian Tang, Zonapse
related to Function · 5
Occludin → Furthermore, Indeed, MDCK, Studies, The
related to Protein structure · 5
Occludin → C-terminus, N-terminus, Occludin's, The, These
related to Disease linkage · 4
Occludin → BLC-PMG, Disruption, Mutation, Strategies
related to Interactions · 3
Occludin → Tight, YES1, ZO-1
Band · 2
Occludin → 13 D1|13 53.23 cM, 5q13.2

Important terminology Word statistics

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Important terminology

tight junction cells gene human function protein important shown bp expression epithelial cancer chr band chromosome domains location barrier junctions

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
OccludinAliasesOCLN, BLCPMG, PPP1R115, occludin, PTORCH11.00infobox
OccludinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1WPA, 1XAW, 3G7C1.00infobox
OccludinBand5q13.21.00infobox
OccludinBand13 D1|13 53.23 cM1.00infobox
OccludinBgeeislet of Langerhans1.00infobox
OccludinBgeemucosa of ileum1.00infobox
OccludinBgeepancreatic ductal cell1.00infobox
OccludinBgeeright lobe of thyroid gland1.00infobox
OccludinBgeebody of pancreas1.00infobox
OccludinBgeeleft lobe of thyroid gland1.00infobox
OccludinBgeegonad1.00infobox
OccludinBgeesural nerve1.00infobox
OccludinBgeerectum1.00infobox
OccludinBgeeright lung1.00infobox
OccludinBgeechoroid plexus of fourth ventricle1.00infobox
OccludinBgeeleft colon1.00infobox
OccludinBgeejejunum1.00infobox
OccludinBgeeduodenum1.00infobox
OccludinBgeeileum1.00infobox
OccludinBgeeseminal vesicula1.00infobox
OccludinBgeeright lung lobe1.00infobox
OccludinBgeemigratory enteric neural crest cell1.00infobox
OccludinBgeestomach1.00infobox
OccludinBgeeleft lung lobe1.00infobox
OccludinBioGPSn/a1.00infobox
OccludinChr.Chromosome 5 (human)1.00infobox
OccludinChr.Chromosome 13 (mouse)1.00infobox
OccludinDatabasesNCBI: entry; OMA: entry1.00infobox
OccludinEnd69,558,104 bp1.00infobox
OccludinEnd100,689,226 bp1.00infobox

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