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Autocrine signaling

Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes in the cell. This can be contrasted with paracrine signaling, intracrine signaling, or classical endocrine signaling.

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Cancer

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Autocrine signaling

Nodes76
Edges75
Triples54
Avg. degree1.97
Density0.026316
Components1

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Autocrine signaling

Top relations

related to IL-6 · 16
Autocrine signaling → Another, Both, EGFR, For, Further, HER2, HER2-overexpressing, IL-6, IL-6/STAT3, Interleukin, Notch-3, Recent, Several, Similarly, STAT3, Their
related to Development of therapeutic targets · 12
Autocrine signaling → For, HER2, IL-6, In, In HER2, NRG1, STAT3, The, This, VEGF-A, VEGFR-2, Wnt
related to Promotion of metastasis · 11
Autocrine signaling → Autocrine PDGFR, EMT, In, Metastasis, One, PDGF/PDGFR, PDGFR, PDGFRα, STAT1, The, This
related to VEGF · 7
Autocrine signaling → Another, Evidence, Instead, Moreover, VEGF, VEGF's, VEGF-dependent
related to Cancer · 3
Autocrine signaling → Autocrine, One, Tumor
is a · 1
Autocrine signaling → form of cell signaling in which a cell secretes a hormone or chemical messenger

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Important terminology

autocrine signaling cancer cells il-6 breast tumor stat3 growth receptors pathway example survival cell wnt therapeutic her2 activation loop vegf

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Autocrine signalingis aform of cell signaling in which a cell secretes a hormone or chemical messenger0.90text
macrophage activationinstance ofThese T cells can then go on to perform effector functions0.80text
B cell activationinstance ofThese T cells can then go on to perform effector functions0.80text
and cell-mediated cytotoxicityinstance ofThese T cells can then go on to perform effector functions0.80text
gefitinib have shown limited therapeutic successinstance ofEGFR-specific tyrosine kinase inhibitors0.80text
Autocrine signalingrelated to CancerTumor0.60section
Autocrine signalingrelated to CancerOne0.60section
Autocrine signalingrelated to CancerAutocrine0.60section
Autocrine signalingrelated to Development of therapeutic targetsThe0.60section
Autocrine signalingrelated to Development of therapeutic targetsFor0.60section
Autocrine signalingrelated to Development of therapeutic targetsWnt0.60section
Autocrine signalingrelated to Development of therapeutic targetsIn0.60section

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