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Anthracycline

Anthracyclines are a class of drugs used in cancer chemotherapy that are extracted from Streptomyces peucetius bacterium. These compounds are used to treat many cancers, including leukemias, lymphomas, breast, stomach, uterine, ovarian, bladder cancer, and lung cancers. The first anthracycline discovered was daunorubicin (trade name Daunomycin), which is…

History, Side effects & Mechanism of action

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Overview

History

Mechanism of action

Side effects

Liposomal-based clinical formulations

Adverse drug interactions

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Map overview Semantic statistics

Anthracycline

Nodes71
Edges70
Triples101
Avg. degree1.97
Density0.028169
Components1

How this topic connects Entity context

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Anthracycline

Top relations

related to References · 16
Anthracycline → Alison Cheong, Anthracyclines, CC BY, December, ISSN, Lock-gray-alt-2, Lock-green, Lock-red-alt-2, Medicine, PDF, Sean McGrath, Suzanne Cutts, This, Wikidata Q60638523, WikiJournal, Wikisource-logo
related to history · 12
Anthracycline → About, Daunorubicin, Di Marco, Doxorubicin, Dubost, Farmitalia Research Laboratories, France, Initially, It, Italy, Streptomyces, This
related to Adverse drug interactions · 11
Anthracycline → As, Bacillus Calmette-Guerin, Cytochrome P450, Drug, Drugs, HER2, Several, Taxanes, The, Though, Trastuzumab
related to Topoisomerase II poison · 8
Anthracycline → Anthracyclines, DNA, DNA-topoisomerase II, II, II-mediated DNA, This, Topoisomerase-II, When
related to Reactive oxygen species · 7
Anthracycline → Converting, DNA, In, NADH, P450, ROS, The
has effect · 6
Anthracycline → Anthracycline-mediated, Cardiotoxicity, Fortunately, Hence, There, Two
related to Clinical implications · 6
Anthracycline → HER2, IIα, Results, The, This, TOP2A
related to DNA adduct formation · 5
Anthracycline → Anthracyclines, DNA, GpC, Such, The
related to Liposomal-based clinical formulations · 5
Anthracycline → Currently, DDS, Liposomal, Liposomes, The
related to DNA Intercalation · 4
Anthracycline → Anthracyclines, DNA, RNA, The

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Important terminology

anthracyclines doxorubicin dna cardiotoxicity cancer drug used breast patients also heart cardiac reduce due daunorubicin effects first drugs adverse dose

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Anthracyclinecausesleft ventricle dysfunction and with continued dosage reaches a certain threshold that can be clinically detected by non-invasive techniques such as 2D echocardiography and strai…0.90text
cytochrome P450 reductaseinstance ofin the presence of oxidoreductive enzymes0.80text
NADH dehydrogenaseinstance ofin the presence of oxidoreductive enzymes0.80text
xanthine oxidaseinstance ofin the presence of oxidoreductive enzymes0.80text
2D echocardiographyinstance ofReceiving cumulative doses of anthracycline causes left ventricle dysfunction and with continued dosage reaches a certain threshold that can be clinically detected by non-invasi…0.80text
strain rate imaginginstance ofReceiving cumulative doses of anthracycline causes left ventricle dysfunction and with continued dosage reaches a certain threshold that can be clinically detected by non-invasi…0.80text
catalaseinstance ofdisplaying a low level of anti-oxidant enzymes0.80text
superoxide dismutase for detoxifying anthracycline-mediated ROS.The mechanisms accounting for anthracycline-induced cardiac damage are complexinstance ofdisplaying a low level of anti-oxidant enzymes0.80text
interrelatedinstance ofdisplaying a low level of anti-oxidant enzymes0.80text
epirubicininstance ofOther novel anthracycline analogues0.80text
idarubicin also provide options to reduce adverse cardiac eventsinstance ofOther novel anthracycline analogues0.80text
Bacillus Calmette-Guerin therapy for bladder cancerinstance ofAs they act as antibiotics anthracyclines can reduce the effectiveness of live culture treatments0.80text

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