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Proinsulin

Proinsulin is the prohormone precursor to insulin made in the beta cells of the Pancreatic Islets, specialized regions of the pancreas. In humans, proinsulin is encoded by the INS gene. The pancreatic islets only secrete between 1% and 3% of proinsulin intact. However, because proinsulin has a longer half life than insulin, it can account for anywhere…

Regions, Synthesis and Post-translational Modification & Medical Relevance

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Domains
InterPro
HGNC
6081
Locus
Chr. 11 p15.5
NCBI gene
3630
OMIM
176730
RefSeq
NM_000207

Topics to explore

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Overview

Structure

Synthesis and Post-translational Modification

Immunogenicity

Medical Relevance

Advanced semantic analysis

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Map overview Semantic statistics

Proinsulin

Nodes36
Edges35
Triples46
Avg. degree1.94
Density0.055556
Components1

How this topic connects Entity context

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Proinsulin

Top relations

related to Synthesis and Post-translational Modification · 14
Proinsulin → C-peptide, Golgi, II, It, Mature, PC1, PC2, PC3, The, The C-peptide, This, Type, When, Zn
related to Diabetes Mellitus · 4
Proinsulin → Additional, If, Increased, This
related to Immunogenicity · 4
Proinsulin → Since, This, When, With
related to Neonatal Diabetes Mellitus · 4
Proinsulin → However, Postnatal, Regulation, Thus
related to Structure · 4
Proinsulin → The, There, These, Two
is a · 2
Proinsulin → final single chain protein structure secreted by cells before cleavage into mature insulin, prohormone precursor to insulin made in the beta cells of the Pancreatic Islets
related to Medical Relevance · 2
Proinsulin → Historically, However
see also · 2
Proinsulin → PC1, PC2
Domains · 1
Proinsulin → InterPro
HGNC · 1
Proinsulin → 6081

Important terminology Word statistics

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Important terminology

insulin mature chain structure peptide residues diabetes disulfide bonds cells c-peptide chains two pancreatic islets modification type however concentrations metabolic

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ProinsulinDomainsInterPro1.00infobox
ProinsulinHGNC60811.00infobox
ProinsulinLocusChr. 11 p15.51.00infobox
ProinsulinNCBI gene36301.00infobox
ProinsulinOMIM1767301.00infobox
ProinsulinRefSeqNM_0002071.00infobox
ProinsulinSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
ProinsulinStructuresSwiss-model1.00infobox
ProinsulinSymbolINS1.00infobox
ProinsulinUniProtP013081.00infobox
Proinsulinis aprohormone precursor to insulin made in the beta cells of the Pancreatic Islets0.90text
Proinsulinis afinal single chain protein structure secreted by cells before cleavage into mature insulin0.90text

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    Min side: 3
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