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Amrinone: Art, PDE-III inhibition and cardiac function & Effects in congestive heart failure

Amrinone, also known as inamrinone, and sold as Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may improve the prognosis in patients with congestive heart failure. Amrinone has been shown to increase the contractions initiated in the heart by high-gain calcium induced calcium release (CICR). The positive inotropic effect of…

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Amrinone topic overview

The analysis highlights Art, PDE-III inhibition and cardiac function and Effects in congestive heart failure as prominent areas in the source structure around Amrinone.

Related topics
38
Source areas
10
Connected nodes
48
Extracted relationships
59
Concept neighborhoods
20
Bridge connections
48

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

PDE-III inhibition and cardiac function · 12 topics
Overview · 5 topics
Effects in congestive heart failure · 4 topics
Side effects · 4 topics
Naming · 3 topics
Actions · 2 topics
Amrinone discovery and progression · 2 topics
Contraindications · 2 topics
Precautions · 2 topics
Synthesis · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
International Drug Names
ATC code
C01CE01 (WHO)
Bioavailability
n/a
CAS Number
60719-84-8 Y
ChEBI
CHEBI:2686

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Actions

PDE-III inhibition and cardiac function

Effects in congestive heart failure

Contraindications

Precautions

Side effects

Amrinone discovery and progression

Naming

Synthesis

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Amrinone connects Entity context

The extracted context around Amrinone shows recurring relationship patterns in the source. For example, Amrinone → An, Both, Ca2, ER, Furthermore, In, L-type Ca2, O2, PDE III, PKA, SERCA, There, When PDE III Another extracted example is Amrinone → An IV, CHF, CO, Congestive, EDRF, GMP, Patients, SV, The, This. Use these groups to spot repeated connection types before inspecting the individual relationships.

Amrinone

Top relations

related to PDE-III inhibition and cardiac function · 13
Amrinone → An, Both, Ca2, ER, Furthermore, In, L-type Ca2, O2, PDE III, PKA, SERCA, There, When PDE III
has effect · 10
Amrinone → An IV, CHF, CO, Congestive, EDRF, GMP, Patients, SV, The, This
related to Precautions · 5
Amrinone → Blood, ECG, Furosemide, IV, May
related to Amrinone discovery and progression · 4
Amrinone → Currently, Early, Some, The
related to Naming · 2
Amrinone → INN, United States Adopted Name
3D model (JSmol) · 1
Amrinone → Interactive image
AHFS/Drugs.com · 1
Amrinone → International Drug Names
ATC code · 1
Amrinone → C01CE01 (WHO)
Bioavailability · 1
Amrinone → n/a
CAS Number · 1
Amrinone → 60719-84-8 Y

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

heart failure camp increase cardiac effects congestive drug inotropic patients administration calcium effect contraction pka inamrinone increases vascular pressure chf

Amrinone relationships Subject–Predicate–Object triples

TTTA extracted 59 structured relationships around Amrinone. Examples in this analysis include Amrinone → 3D model (JSmol) → Interactive image and Amrinone → AHFS/Drugs.com → International Drug Names. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Amrinone3D model (JSmol)Interactive image1.00infobox
AmrinoneAHFS/Drugs.comInternational Drug Names1.00infobox
AmrinoneATC codeC01CE01 (WHO)1.00infobox
AmrinoneBioavailabilityn/a1.00infobox
AmrinoneCAS Number60719-84-8 Y1.00infobox
AmrinoneChEBICHEBI:26861.00infobox
AmrinoneChEMBLChEMBL12856 Y1.00infobox
AmrinoneChemSpider3570 Y1.00infobox
AmrinoneCompTox Dashboard (EPA)DTXSID90226031.00infobox
AmrinoneDrugBankDB01427 Y1.00infobox
AmrinoneECHA InfoCard100.056.7001.00infobox
AmrinoneElimination half-life5 to 8 hours1.00infobox
AmrinoneExcretionRenal (63%) and fecal (18%)1.00infobox
AmrinoneFormulaC10H9N3O1.00infobox
AmrinoneIUPHAR/BPS72021.00infobox
AmrinoneKEGGD00231 Y1.00infobox
AmrinoneLegal statusIn general: ℞ (Prescription only)1.00infobox
AmrinoneMetabolismHepatic1.00infobox
AmrinoneMolar mass187.202 g·mol−11.00infobox
AmrinoneOther namesinamrinone (USAN US)1.00infobox
AmrinoneProtein binding10 to 49%1.00infobox
AmrinonePubChem CID36981.00infobox
AmrinoneRoutes of administrationIntravenous1.00infobox
AmrinoneTrade namesInocor1.00infobox
AmrinoneUNIIJUT23379TN1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Amrinone bring nearby vocabulary together. In this analysis, examples include Heart, Failure and Effects. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Amrinone
    • Heart
    • Failure
    • Effects
    • Decreasing
    • Inamrinone
    • Inotropic
    • Administration
    • Cardiac
    • Increase
    • Cicr
    • High-gain
    • Inocor
  • amrinone
    • Heart
    • Failure
    • Effects
    • Decreasing
    • Inamrinone
    • Inotropic
    • Administration
    • Cardiac
    • Increase
    • Cicr
    • High-gain
    • Inocor
  • effects in congestive heart failure
    • Failure
    • Heart
    • Effects
    • Side
    • Patients
    • Administration
    • Drug
    • Inotropic
    • Chf
    • May
    • Inocor
    • Protein
  • amrinone discovery and progression
    • Heart
    • Failure
    • Effects
    • Decreasing
    • Inamrinone
    • Inotropic
    • Administration
    • Cardiac
    • Increase
    • Cicr
    • High-gain
    • Inocor
  • heart failure
    • Failure
    • Heart
    • Effects
    • Patients
    • Chf
    • May
    • Side
    • Administration
    • Calcium
    • Increase
    • Inocor
    • Protein
  • calcium induced calcium release
    • Increase
    • Release
    • Reticulum
    • Sarcoplasmic
    • Camp
    • Contraction
    • Cicr
    • High-gain
    • Kinase
    • Smooth
    • Ca2
    • Decreasing
  • calcium spark
    • Increase
    • Release
    • Reticulum
    • Sarcoplasmic
    • Camp
    • Contraction
    • Cicr
    • High-gain
    • Kinase
    • Ca2
    • Decreasing
    • Muscle
  • cardiac output
    • Increases
    • Decreasing
    • Pressure
    • Administration
    • Drug
    • Inocor
    • Protein
    • Iii
    • Inamrinone
    • Muscle
    • Pde
    • Side

Connections between topic areas Semantic bridges

For Amrinone, one of the stronger structural bridges in this analysis connects Amrinone with PDE-III inhibition and cardiac function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
AmrinonePDE-III inhibition and cardiac function · splits 36 ⟂ 13
AmrinoneOverview · splits 43 ⟂ 6
AmrinoneEffects in congestive heart failure · splits 44 ⟂ 5
AmrinoneSide effects · splits 44 ⟂ 5
AmrinoneNaming · splits 45 ⟂ 4
AmrinoneActions · splits 46 ⟂ 3
AmrinoneContraindications · splits 46 ⟂ 3
AmrinonePrecautions · splits 46 ⟂ 3
AmrinoneAmrinone discovery and progression · splits 46 ⟂ 3
AmrinoneSynthesis · splits 46 ⟂ 3

Map overview Semantic statistics

Amrinone

Nodes49
Edges48
Triples59
Avg. degree1.96
Density0.040816
Components1

Source & methodology

TTTA analyzes the structure around Amrinone to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, PDE-III inhibition and cardiac function & Effects in congestive heart failure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Amrinone · EN edition · Analysis: TopicsToTalkAbout

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