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Amrinone

Amrinone, also known as inamrinone, and sold as Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may improve the prognosis in patients with congestive heart failure. Amrinone has been shown to increase the contractions initiated in the heart by high-gain calcium induced calcium release (CICR). The positive inotropic effect of…

Art, PDE-III inhibition and cardiac function & Effects in congestive heart failure

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PDE-III inhibition and cardiac function

Vascular smooth muscleSarcoplasmic reticulumSmooth ERPKAKinase
12 related topics

Effects in congestive heart failure

Cyclic GMPCardiac outputStroke volumePeripheral vascular resistance
4 related topics

Side effects

ThrombocytopeniaNauseaDiarrheaArrhythmias
4 related topics

Naming

INNUnited States Adopted NameAmiodarone
3 related topics

Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
International Drug Names
ATC code
C01CE01 (WHO)
Bioavailability
n/a
CAS Number
60719-84-8 Y
ChEBI
CHEBI:2686

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PDE-III inhibition and cardiac function

Effects in congestive heart failure

Contraindications

Precautions

Side effects

Amrinone discovery and progression

Naming

Synthesis

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Map overview Semantic statistics

Amrinone

Nodes49
Edges48
Triples59
Avg. degree1.96
Density0.040816
Components1

How this topic connects Entity context

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Amrinone

Top relations

related to PDE-III inhibition and cardiac function · 13
Amrinone → An, Both, Ca2, ER, Furthermore, In, L-type Ca2, O2, PDE III, PKA, SERCA, There, When PDE III
has effect · 10
Amrinone → An IV, CHF, CO, Congestive, EDRF, GMP, Patients, SV, The, This
related to Precautions · 5
Amrinone → Blood, ECG, Furosemide, IV, May
related to Amrinone discovery and progression · 4
Amrinone → Currently, Early, Some, The
related to Naming · 2
Amrinone → INN, United States Adopted Name
3D model (JSmol) · 1
Amrinone → Interactive image
AHFS/Drugs.com · 1
Amrinone → International Drug Names
ATC code · 1
Amrinone → C01CE01 (WHO)
Bioavailability · 1
Amrinone → n/a
CAS Number · 1
Amrinone → 60719-84-8 Y

Important terminology Word statistics

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Important terminology

heart failure camp increase cardiac effects congestive drug inotropic patients administration calcium effect contraction pka inamrinone increases vascular pressure chf

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Amrinone3D model (JSmol)Interactive image1.00infobox
AmrinoneAHFS/Drugs.comInternational Drug Names1.00infobox
AmrinoneATC codeC01CE01 (WHO)1.00infobox
AmrinoneBioavailabilityn/a1.00infobox
AmrinoneCAS Number60719-84-8 Y1.00infobox
AmrinoneChEBICHEBI:26861.00infobox
AmrinoneChEMBLChEMBL12856 Y1.00infobox
AmrinoneChemSpider3570 Y1.00infobox
AmrinoneCompTox Dashboard (EPA)DTXSID90226031.00infobox
AmrinoneDrugBankDB01427 Y1.00infobox
AmrinoneECHA InfoCard100.056.7001.00infobox
AmrinoneElimination half-life5 to 8 hours1.00infobox
AmrinoneExcretionRenal (63%) and fecal (18%)1.00infobox
AmrinoneFormulaC10H9N3O1.00infobox
AmrinoneIUPHAR/BPS72021.00infobox
AmrinoneKEGGD00231 Y1.00infobox
AmrinoneLegal statusIn general: ℞ (Prescription only)1.00infobox
AmrinoneMetabolismHepatic1.00infobox
AmrinoneMolar mass187.202 g·mol−11.00infobox
AmrinoneOther namesinamrinone (USAN US)1.00infobox
AmrinoneProtein binding10 to 49%1.00infobox
AmrinonePubChem CID36981.00infobox
AmrinoneRoutes of administrationIntravenous1.00infobox
AmrinoneTrade namesInocor1.00infobox
AmrinoneUNIIJUT23379TN1.00infobox

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