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Alpha-actinin-1: Interactions, Function & Overview

Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.

Language: English [EN]
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Alpha-actinin-1 topic overview

The analysis highlights Interactions, Function and Overview as prominent areas in the source structure around Alpha-actinin-1.

Related topics
19
Source areas
3
Connected nodes
22
Extracted relationships
128
Concept neighborhoods
8
Bridge connections
22

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 10 topics
Function · 7 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
ACTN1, BDPLT15, actinin alpha 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EYI, 2EYN, 2N8Z, 2N8Y
Band
14q24.1|14q22-q24 · 12 C3|12 36.49 cM
Bgee
saphenous vein · ascending aorta · right coronary artery · popliteal artery · tibial arteries
BioGPS
More reference expression data
Chr.
Chromosome 14 (human) · Chromosome 12 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Alpha-actinin-1 connects Entity context

The extracted context around Alpha-actinin-1 shows recurring relationship patterns in the source. For example, Alpha-actinin-1 → actin binding, actin crosslink formation, actin filament, actin filament binding, actin filament bundle assembly, actin filament network formation, actin filament organization, brush border, calcium ion binding, cell junction, cell projection, cell-cell junction, cytoplasm, cytoskeleton, cytosol, double-stranded RNA binding, extracellular exosome, extracellular region, extracellular space, fascia adherens Another extracted example is Alpha-actinin-1 → ascending aorta, ciliary body, Descending thoracic aorta, endothelial cell of lymphatic vessel, external carotid artery, gastric mucosa, granulocyte, Ileal epithelium, internal carotid artery, myometrium, popliteal artery, right coronary artery, saphenous vein, smooth muscle tissue, stria vascularis, stromal cell of endometrium, tibial arteries, tunica media of zone of aorta, vestibular membrane of cochlear duct. Use these groups to spot repeated connection types before inspecting the individual relationships.

Alpha-actinin-1

Top relations

Gene ontology · 49
Alpha-actinin-1 → actin binding, actin crosslink formation, actin filament, actin filament binding, actin filament bundle assembly, actin filament network formation, actin filament organization, brush border, calcium ion binding, cell junction, cell projection, cell-cell junction, cytoplasm, cytoskeleton, cytosol, double-stranded RNA binding, extracellular exosome, extracellular region, extracellular space, fascia adherens
Bgee · 19
Alpha-actinin-1 → ascending aorta, ciliary body, Descending thoracic aorta, endothelial cell of lymphatic vessel, external carotid artery, gastric mucosa, granulocyte, Ileal epithelium, internal carotid artery, myometrium, popliteal artery, right coronary artery, saphenous vein, smooth muscle tissue, stria vascularis, stromal cell of endometrium, tibial arteries, tunica media of zone of aorta, vestibular membrane of cochlear duct
RNA expression pattern · 19
Alpha-actinin-1 → ascending aorta, ciliary body, Descending thoracic aorta, endothelial cell of lymphatic vessel, external carotid artery, gastric mucosa, granulocyte, Ileal epithelium, internal carotid artery, myometrium, popliteal artery, right coronary artery, saphenous vein, smooth muscle tissue, stria vascularis, stromal cell of endometrium, tibial arteries, tunica media of zone of aorta, vestibular membrane of cochlear duct
related to Interactions · 11
Alpha-actinin-1 → CDK5R1, CDK5R2, Collagen, GIPC1, N1, PDLIM1, Protein, PTPrho, PTPRT, SSX2IP, XVII
related to Function · 4
Alpha-actinin-1 → Alpha, F-actin, In, Z-disc
is a · 3
Alpha-actinin-1 → F-actin cross-linking protein, non-muscle cytoskeletal isoform found along microfilament bundles and adherens-type junctions, protein that in humans is encoded by the ACTN1 gene
Band · 2
Alpha-actinin-1 → 12 C3|12 36.49 cM, 14q24.1|14q22-q24
Chr. · 2
Alpha-actinin-1 → Chromosome 12 (mouse), Chromosome 14 (human)
End · 2
Alpha-actinin-1 → 68,979,440 bp, 80,307,145 bp
Aliases · 1
Alpha-actinin-1 → ACTN1, BDPLT15, actinin alpha 1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp gene human chr band actn1 alpha chromosome 14 protein location external actin mouse function search 979 440 end 68

Alpha-actinin-1 relationships Subject–Predicate–Object triples

TTTA extracted 128 structured relationships around Alpha-actinin-1. Examples in this analysis include Alpha-actinin-1 → Aliases → ACTN1, BDPLT15, actinin alpha 1 and Alpha-actinin-1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EYI, 2EYN, 2N8Z, 2N8Y. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Alpha-actinin-1AliasesACTN1, BDPLT15, actinin alpha 11.00infobox
Alpha-actinin-1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EYI, 2EYN, 2N8Z, 2N8Y1.00infobox
Alpha-actinin-1Band14q24.1|14q22-q241.00infobox
Alpha-actinin-1Band12 C3|12 36.49 cM1.00infobox
Alpha-actinin-1Bgeesaphenous vein1.00infobox
Alpha-actinin-1Bgeeascending aorta1.00infobox
Alpha-actinin-1Bgeeright coronary artery1.00infobox
Alpha-actinin-1Bgeepopliteal artery1.00infobox
Alpha-actinin-1Bgeetibial arteries1.00infobox
Alpha-actinin-1Bgeestromal cell of endometrium1.00infobox
Alpha-actinin-1BgeeDescending thoracic aorta1.00infobox
Alpha-actinin-1Bgeesmooth muscle tissue1.00infobox
Alpha-actinin-1Bgeemyometrium1.00infobox
Alpha-actinin-1Bgeegastric mucosa1.00infobox
Alpha-actinin-1Bgeevestibular membrane of cochlear duct1.00infobox
Alpha-actinin-1BgeeIleal epithelium1.00infobox
Alpha-actinin-1Bgeegranulocyte1.00infobox
Alpha-actinin-1Bgeestria vascularis1.00infobox
Alpha-actinin-1Bgeetunica media of zone of aorta1.00infobox
Alpha-actinin-1Bgeeendothelial cell of lymphatic vessel1.00infobox
Alpha-actinin-1Bgeeexternal carotid artery1.00infobox
Alpha-actinin-1Bgeeinternal carotid artery1.00infobox
Alpha-actinin-1Bgeeciliary body1.00infobox
Alpha-actinin-1BioGPSMore reference expression data1.00infobox
Alpha-actinin-1Chr.Chromosome 14 (human)1.00infobox
Alpha-actinin-1Chr.Chromosome 12 (mouse)1.00infobox
Alpha-actinin-1DatabasesNCBI: entry; OMA: entry1.00infobox
Alpha-actinin-1End68,979,440 bp1.00infobox
Alpha-actinin-1End80,307,145 bp1.00infobox
Alpha-actinin-1EnsemblENSG000000721101.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Alpha-actinin-1 bring nearby vocabulary together. In this analysis, examples include Protein, Actin and Humans. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Location
    • Human
    • Alpha
    • Chromosome
    • Bp
    • Chr
    • Actinin
    • C3
    • Cell
    • End
    • External
    • Function
  • collagen, type xvii, alpha 1
    • Location
    • Cell
    • External
    • Function
    • Gene
    • Human
    • Links
    • Search
    • Ucsc
    • Chromosome
    • Protein
    • Bp
  • function
    • Search
    • Alpha
    • Chromosome
    • Location
    • Bp
    • Chr
    • Gene
    • Human
    • Actinin
    • Binding
    • C3
    • Cell
  • cytoskeletal proteins
    • Membrane
    • End
    • External
    • Function
    • Intracellular
    • Mouse
    • Muscle
    • Search
    • Smooth
    • Ucsc
    • Location
    • Protein
  • Alpha-actinin-1
    • Protein
    • Actin
    • Humans
    • Anchor
    • Binding
    • Cytoskeletal
    • Intracellular
    • Membrane
    • Structures
    • Actn1
    • Alpha
    • Gene
  • alpha-actinin-1
    • Protein
    • Actin
    • Humans
    • Anchor
    • Binding
    • Cytoskeletal
    • Intracellular
    • Membrane
    • Structures
    • Actn1
    • Alpha
    • Gene
  • protein
    • Anchor
    • Search
    • Smooth
    • Structures
    • Ucsc
  • protein kinase n1
    • Anchor
    • Search
    • Smooth
    • Structures
    • Ucsc

Connections between topic areas Semantic bridges

For Alpha-actinin-1, one of the stronger structural bridges in this analysis connects Alpha-actinin-1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Alpha-actinin-1Interactions · splits 12 ⟂ 11
Alpha-actinin-1Function · splits 15 ⟂ 8
Alpha-actinin-1Overview · splits 20 ⟂ 3

Map overview Semantic statistics

Alpha-actinin-1

Nodes23
Edges22
Triples128
Avg. degree1.91
Density0.086957
Components1

Source & methodology

TTTA analyzes the structure around Alpha-actinin-1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Alpha-actinin-1 · EN edition · Analysis: TopicsToTalkAbout

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