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Naproxen

Naproxen, sold under the brand name Aleve among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, menstrual cramps, and inflammatory diseases such as rheumatoid arthritis, gout and fever. It is taken orally. It is available in immediate and delayed release formulations. Onset of effects is within an hour and lasts for up to…

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
G02CC02 (WHO) M01AE02 (WHO), M02AA12 (WHO), M01AE56 (WHO), M01AE52 (WHO)
Bioavailability
100% (by mouth)
CAS Number
22204-53-1 Y
ChEBI
CHEBI:7476 Y

Topics to explore

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Overview

Medical uses

Adverse effects

Drug-drug interactions

Pharmacology

Chemistry

Society and culture

Ecological effects

Research

Veterinary use

Advanced semantic analysis

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Map overview Semantic statistics

Naproxen

Nodes117
Edges116
Triples161
Avg. degree1.98
Density0.017094
Components1

How this topic connects Entity context

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Naproxen

Top relations

related to Access restrictions · 25
Naproxen → Aleve, Anaprox, Bayer HealthCare, British Columbia, Canada, Drug Administration, FDA, Feminax Ultra, Food, In, In Australia, It, January, July, Labrador, Naprosyn, Netherlands, Newfoundland, OTC, Quebec
related to Brand names · 22
Naproxen → Accord, Aleve, Anaprox, Antalgin, Apranax, Eox, Feminax Ultra, Flanax, Inza, It, Maxidol, Nalgesin, Naposin, Naprelan, Naprogesic, Naprosyn, Narocin, Pronaxen, Proxen, Soproxen
has effect · 10
Naproxen → Although, Common, Drug Administration, FDA, Food, Heavy, In October, NSAIDs, Some, They
related to Cardiovascular · 8
Naproxen → Cardiovascular, Conversely, COX-1, COX-2, CVD, NSAID, NSAIDs, The
related to Pharmacogenetics · 7
Naproxen → CYP2C9, However, In, NSAID-induced, PK, Studies, The
related to Gastrointestinal · 6
Naproxen → As, COX-2, In, NSAIDs, Persons, To
related to Drug-drug interactions · 5
Naproxen → Alcohol, NSAIDs, SSRI, SSRIs, The
related to Pharmacokinetics · 5
Naproxen → An, CYP1A2, CYP2C9, It, O-desmethylnaproxen
Legal status · 4
Naproxen → AU: S2 (Pharmacy medicine) when in preparations that contain no more than 15 days' supply. Otherwise it is Schedule 4 (Prescription only)., CA: OTC / Rx-only, UK: POM (Prescription only) / P, US: OTC / Rx-only
related to Available formulations · 4
Naproxen → Extended-release, Imprint L490, Round, The

Important terminology Word statistics

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Important terminology

risk nsaids effects gastrointestinal available pain sodium anti-inflammatory use brand nsaid drug disease united name ulcers pregnancy mg bleeding may

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Naproxen3D model (JSmol)Interactive image1.00infobox
NaproxenAHFS/Drugs.comMonograph1.00infobox
NaproxenATC codeG02CC02 (WHO) M01AE02 (WHO), M02AA12 (WHO), M01AE56 (WHO), M01AE52 (WHO)1.00infobox
NaproxenBioavailability100% (by mouth)1.00infobox
NaproxenCAS Number22204-53-1 Y1.00infobox
NaproxenChEBICHEBI:7476 Y1.00infobox
NaproxenChEMBLChEMBL154 Y1.00infobox
NaproxenChemSpider137720 Y1.00infobox
NaproxenCompTox Dashboard (EPA)DTXSID40406861.00infobox
NaproxenDrugBankDB00788 Y1.00infobox
NaproxenDuration of action12 hours1.00infobox
NaproxenECHA InfoCard100.040.7471.00infobox
NaproxenElimination half-life14 hours (adults)1.00infobox
NaproxenExcretionKidney1.00infobox
NaproxenFormulaC14H14O31.00infobox
NaproxenKEGGD00118 Y1.00infobox
NaproxenKEGGas salt: D00970 Y1.00infobox
NaproxenLegal statusAU: S2 (Pharmacy medicine) when in preparations that contain no more than 15 days' supply. Otherwise it is Schedule 4 (Prescription only).1.00infobox
NaproxenLegal statusCA: OTC / Rx-only1.00infobox
NaproxenLegal statusUK: POM (Prescription only) / P1.00infobox
NaproxenLegal statusUS: OTC / Rx-only1.00infobox
NaproxenLicense dataUS DailyMed: Naproxen1.00infobox
NaproxenMedlinePlusa6810291.00infobox
NaproxenMelting point152–154 °C (306–309 °F)1.00infobox
NaproxenMetabolismLiver (to 6-desmethylnaproxen)1.00infobox
NaproxenMolar mass230.263 g·mol−11.00infobox
NaproxenOnset of action1 hour1.00infobox
NaproxenPDB ligandNPX (PDBe, RCSB PDB)1.00infobox
NaproxenPregnancy categoryAU: C1.00infobox
NaproxenPronunciation/nəˈprɒksən/1.00infobox

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