Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

ABCA4: Function, Clinical significance & Structure

ATP-binding cassette, sub-family A (ABC1), member 4, also known as ABCA4 or ABCR, is a protein which in humans is encoded by the ABCA4 gene.

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

ABCA4 topic overview

The analysis highlights Function, Clinical significance and Structure as prominent areas in the source structure around ABCA4.

Related topics
33
Source areas
4
Connected nodes
37
Extracted relationships
149
Concept neighborhoods
11
Bridge connections
37

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 11 topics
Clinical significance · 9 topics
Function · 9 topics
Structure · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

7.6.2.1
Aliases
ABCA4, AW050280, Abc10, Abcr, D430003I15Rik, RmP, ARMD2, CORD3, FFM, RP19, STGD, STGD1, ATP binding cassette subfamily A member 4
Band
1p22.1 · 3 G1|3 52.94 cM
Bgee
retinal pigment epithelium · gonad · testicle · right uterine tube · Epithelium of choroid plexus
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 3 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How ABCA4 connects Entity context

The extracted context around ABCA4 shows recurring relationship patterns in the source. For example, ABCA4 → ATP binding, ATPase activity, ATPase-coupled intramembrane lipid transporter activity, ATPase-coupled transmembrane transporter activity, endoplasmic reticulum, integral component of membrane, integral component of plasma membrane, intracellular membrane-bounded organelle, lipid transport, lipid transporter activity, membrane, nucleotide binding, phosphatidylethanolamine flippase activity, phospholipid transfer to membrane, phospholipid translocation, phospholipid transporter activity, photoreceptor cell maintenance, photoreceptor disc membrane, photoreceptor outer segment, phototransduction of visible light Another extracted example is ABCA4 → A2E, ABCR, ABCs, ADP, After, ATP, ATR, ATR/NR-PE, Comparisons, Flippase, From, In, N-retinyl-phosphatidylethanolamine, N-retinylidene-N-retinyl-ethanolamine, NBD, NBDs, NR-PE, NR-PE/ATR, Once, PE. Use these groups to spot repeated connection types before inspecting the individual relationships.

ABCA4

Top relations

Gene ontology · 25
ABCA4 → ATP binding, ATPase activity, ATPase-coupled intramembrane lipid transporter activity, ATPase-coupled transmembrane transporter activity, endoplasmic reticulum, integral component of membrane, integral component of plasma membrane, intracellular membrane-bounded organelle, lipid transport, lipid transporter activity, membrane, nucleotide binding, phosphatidylethanolamine flippase activity, phospholipid transfer to membrane, phospholipid translocation, phospholipid transporter activity, photoreceptor cell maintenance, photoreceptor disc membrane, photoreceptor outer segment, phototransduction of visible light
related to Function · 25
ABCA4 → A2E, ABCR, ABCs, ADP, After, ATP, ATR, ATR/NR-PE, Comparisons, Flippase, From, In, N-retinyl-phosphatidylethanolamine, N-retinylidene-N-retinyl-ethanolamine, NBD, NBDs, NR-PE, NR-PE/ATR, Once, PE
Bgee · 18
ABCA4 → choroid plexus of fourth ventricle, ciliary body, corneal stroma, corpus epididymis, Epithelium of choroid plexus, epithelium of lens, gonad, iris, jejunal mucosa, neural layer of retina, pineal gland, retinal pigment epithelium, right lobe of liver, right uterine tube, skin of abdomen, tail of embryo, tail of epididymis, testicle
RNA expression pattern · 18
ABCA4 → choroid plexus of fourth ventricle, ciliary body, corneal stroma, corpus epididymis, Epithelium of choroid plexus, epithelium of lens, gonad, iris, jejunal mucosa, neural layer of retina, pineal gland, retinal pigment epithelium, right lobe of liver, right uterine tube, skin of abdomen, tail of embryo, tail of epididymis, testicle
related to Structure · 16
ABCA4 → ABC, ABCR, ATP, ECD, However, NBD, NBDs, Once, One TMD, Previously, RmP, The TMDs, TMD, TMDs, Transcribed ABCA4, When TMDs
related to Clinical significance · 15
ABCA4 → A2E, A2PE, A2PE-H2, Accumulation, Additional, After, ATR, Mutations, N-retinylidene-N-retinyl-phosphatidyl-ethanolamine, NR-PE, NR-PE/ATR, Removal, RPE, Stargardt, STGD
related to External links · 9
ABCA4 → GeneReviews/NIH/NCBI/UW, Medicine, Medicine Medical Subject Headings, MeSH, National Library, Retinitis Pigmentosa OverviewABCA4, This, UCSC Genome Browser, United States National Library
Band · 2
ABCA4 → 1p22.1, 3 G1|3 52.94 cM
Chr. · 2
ABCA4 → Chromosome 1 (human), Chromosome 3 (mouse)
End · 2
ABCA4 → 121,973,772 bp, 94,121,148 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene protein human atr atp binding bp abcr outer nr-pe chr band macular transmembrane cassette chromosome photoreceptor transporter segment location

ABCA4 relationships Subject–Predicate–Object triples

TTTA extracted 149 structured relationships around ABCA4. Examples in this analysis include ABCA4 → 7.6.2.1 → ↗ and ABCA4 → Aliases → ABCA4, AW050280, Abc10, Abcr, D430003I15Rik, RmP, ARMD2, CORD3, FFM, RP19, STGD, STGD1, ATP binding cassette subfamily A member 4. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ABCA47.6.2.11.00infobox
ABCA4AliasesABCA4, AW050280, Abc10, Abcr, D430003I15Rik, RmP, ARMD2, CORD3, FFM, RP19, STGD, STGD1, ATP binding cassette subfamily A member 41.00infobox
ABCA4Band1p22.11.00infobox
ABCA4Band3 G1|3 52.94 cM1.00infobox
ABCA4Bgeeretinal pigment epithelium1.00infobox
ABCA4Bgeegonad1.00infobox
ABCA4Bgeetesticle1.00infobox
ABCA4Bgeeright uterine tube1.00infobox
ABCA4BgeeEpithelium of choroid plexus1.00infobox
ABCA4Bgeetail of epididymis1.00infobox
ABCA4Bgeecorpus epididymis1.00infobox
ABCA4Bgeeright lobe of liver1.00infobox
ABCA4Bgeeskin of abdomen1.00infobox
ABCA4Bgeejejunal mucosa1.00infobox
ABCA4Bgeeneural layer of retina1.00infobox
ABCA4Bgeechoroid plexus of fourth ventricle1.00infobox
ABCA4Bgeeepithelium of lens1.00infobox
ABCA4Bgeeciliary body1.00infobox
ABCA4Bgeeiris1.00infobox
ABCA4Bgeepineal gland1.00infobox
ABCA4Bgeecorneal stroma1.00infobox
ABCA4Bgeetail of embryo1.00infobox
ABCA4BioGPSMore reference expression data1.00infobox
ABCA4Chr.Chromosome 1 (human)1.00infobox
ABCA4Chr.Chromosome 3 (mouse)1.00infobox
ABCA4DatabasesNCBI: entry; OMA: entry1.00infobox
ABCA4End94,121,148 bp1.00infobox
ABCA4End121,973,772 bp1.00infobox
ABCA4EnsemblENSG000001986911.00infobox
ABCA4Entrez241.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around ABCA4 bring nearby vocabulary together. In this analysis, examples include Gene, Protein and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • ABCA4
    • Gene
    • Protein
    • Human
    • Cassette
    • Two
    • Binding
    • Also
    • Atp-binding
    • Member
    • Flippase
    • Function
    • Location
  • abca4
    • Gene
    • Protein
    • Human
    • Cassette
    • Two
    • Binding
    • Also
    • Atp-binding
    • Member
    • Flippase
    • Function
    • Location
  • protein
    • Transmembrane
    • Expressed
    • Retina
    • Flippase
    • Membrane
    • Segment
    • Tmd
    • Transporter
    • Two
    • Across
    • Outer
    • Human
  • gene
    • Human
    • Location
    • Member
    • Chromosome
    • Bp
    • Chr
    • Protein
    • Mouse
    • Band
    • Degeneration
    • Function
    • Photoreceptor
  • function
    • Chromosome
    • Flippase
    • Location
    • Retinoid
    • Bp
    • Chr
    • Human
    • Member
    • Mouse
    • Retina
    • Band
    • Gene
  • retina
    • Segment
    • Mouse
    • Band
    • Chromosome
    • Flippase
    • Function
    • Location
    • Membrane
    • Photoreceptor
    • Retinoid
    • Transfer
    • Transmembrane
  • flippase
    • Function
    • Membrane
    • Retinoid
    • Transfer
    • Transmembrane
    • Protein
    • Mouse
    • Retina
    • Location
    • Photoreceptor
    • Segment
    • Transporter
  • atp-binding cassette transporter
    • Cassette
    • Member
    • Transporter
    • Protein
    • Gene
    • Also
    • Human
    • Abca4
    • Chromosome
    • Function
    • Location
    • Two

Connections between topic areas Semantic bridges

For ABCA4, one of the stronger structural bridges in this analysis connects ABCA4 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ABCA4Overview · splits 26 ⟂ 12
ABCA4Function · splits 28 ⟂ 10
ABCA4Clinical significance · splits 28 ⟂ 10
ABCA4Structure · splits 33 ⟂ 5

Map overview Semantic statistics

ABCA4

Nodes38
Edges37
Triples149
Avg. degree1.95
Density0.052632
Components1

Source & methodology

TTTA analyzes the structure around ABCA4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ABCA4 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.