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Flippase

Flippases are transmembrane lipid transporter proteins located in the cell membrane. They are responsible for aiding the movement of phospholipid molecules between the two layers, or leaflets, that comprise the membrane. This is called transverse diffusion, also known as "flip-flop" transition. Flippases move lipids to the cytosolic layer, usually from…

Lateral and transverse movements, Structure and domains of P4-type flippases & Mechanism of P4-type flippases

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Lateral and transverse movements

MoleculePolarHydrophobicPhospholipid bilayerMark Bretscher
9 related topics

Structure and domains of P4-type flippases

Alpha helicesActuatorConformational changeC-terminal
4 related topics

Mechanism of P4-type flippases

Phosphorylation
1 related topics

Overview

ProteinsCell membranePhospholipidATP hydrolysisP4-ATPases
6 related topics

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Overview

Lateral and transverse movements

Structure and domains of P4-type flippases

Mechanism of P4-type flippases

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Flippase

Nodes25
Edges24
Triples35
Avg. degree1.92
Density0.08
Components1

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Flippase

Top relations

related to Mechanism of P4-type flippases · 21
Flippase → ADP, After ATP, As, ATP, Binding, C-terminal, Dephosphorylation, E1, E1P-ADP, E2, E2P, E2Pi, Further, N-domain, P-domain, P4-type, PL, TGES, The, The A-domain
related to Structure and domains of P4-type flippases · 11
Flippase → Alpha-subunits, ATP, C-terminal, Finally, N-domain, P4-type, The, The A-domain, The P-domain, The P4-type, Transmembrane
related to Different classes of lipid transporters · 3
Flippase → Lipid, P-type FlippaseABC FloppaseScramblases, There

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Important terminology

phospholipid lipid membrane flippases lipids domain movement transverse atp layer p4-type transporters binding conformational change p-domain transmembrane two lateral also

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Flippaserelated to Different classes of lipid transportersLipid0.60section
Flippaserelated to Different classes of lipid transportersThere0.60section
Flippaserelated to Different classes of lipid transportersP-type FlippaseABC FloppaseScramblases0.60section
Flippaserelated to Mechanism of P4-type flippasesTo0.60section
Flippaserelated to Mechanism of P4-type flippasesP4-type0.60section
Flippaserelated to Mechanism of P4-type flippasesATP0.60section
Flippaserelated to Mechanism of P4-type flippasesP-domain0.60section
Flippaserelated to Mechanism of P4-type flippasesAfter ATP0.60section
Flippaserelated to Mechanism of P4-type flippasesE10.60section
Flippaserelated to Mechanism of P4-type flippasesE20.60section
Flippaserelated to Mechanism of P4-type flippasesFurther0.60section
Flippaserelated to Mechanism of P4-type flippasesE2Pi0.60section

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