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Cetirizine

Cetirizine is a second-generation peripherally selective antihistamine used to treat allergic rhinitis (hay fever), dermatitis, urticaria (hives), and runny nose. It is taken by mouth. Effects generally begin within thirty minutes and last for about a day. The degree of benefit is similar to other antihistamines such as diphenhydramine, which is a…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
R06AE07 (WHO) S01GX12 (WHO)
Bioavailability
Well-absorbed (>70%)
CAS Number
83881-51-0 Y
ChEBI
CHEBI:3561 Y

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Overview

Medical uses

Adverse effects

Pharmacology

Chemistry

Availability

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Map overview Semantic statistics

Cetirizine

Nodes107
Edges106
Triples86
Avg. degree1.98
Density0.018692
Components1

How this topic connects Entity context

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Cetirizine

Top relations

related to Pruritus after discontinuation of cetirizine · 14
Cetirizine → Although, April, Discontinuing, Drug Administration, Drug Safety Communication, FAERS, FDA, FDA Adverse Event Reporting, May, On, System, The, The US Food, Their
related to Pharmacodynamics · 8
Cetirizine → As, H1, IC50Tooltip, In, It, PET, The, The Ki
Legal status · 6
Cetirizine → AU: Unscheduled, CA: OTC / Rx-only, NZ: OTC, OTC / Rx-only, UK: General sales list (GSL, OTC) / P, US: OTC / Rx-only
related to Available forms · 5
Cetirizine → In, It, The, UK, US
related to Chemistry · 5
Cetirizine → Analogues, Chemically, D-stereoisomers, L-enantiomer, The
related to Allergies · 3
Cetirizine → Because, Cetirizine's, H1
related to Availability · 3
Cetirizine → In, The, Zyrtec-D
is a · 2
Cetirizine → second-generation peripherally selective antihistamine used to treat allergic rhinitis, therapeutic alternative on the World Health Organization's List of Essential Medicines
3D model (JSmol) · 1
Cetirizine → Interactive image
AHFS/Drugs.com · 1
Cetirizine → Monograph

Important terminology Word statistics

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Important terminology

h1 mg 10 receptor antihistamines 20 available second-generation drug found medication levocetirizine effects hours brain drowsiness histamine administration mouth receptors

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Cetirizine3D model (JSmol)Interactive image1.00infobox
CetirizineAHFS/Drugs.comMonograph1.00infobox
CetirizineATC codeR06AE07 (WHO) S01GX12 (WHO)1.00infobox
CetirizineBioavailabilityWell-absorbed (>70%)1.00infobox
CetirizineCAS Number83881-51-0 Y1.00infobox
CetirizineChEBICHEBI:3561 Y1.00infobox
CetirizineChEMBLChEMBL1000 Y1.00infobox
CetirizineChemSpider2577 Y1.00infobox
CetirizineCompTox Dashboard (EPA)DTXSID40227871.00infobox
CetirizineDrugBankDB00341 Y1.00infobox
CetirizineDuration of action≥24 hours1.00infobox
CetirizineECHA InfoCard100.223.5451.00infobox
CetirizineElimination half-lifeMean: 8.3 hours Range: 6.5–10 hours1.00infobox
CetirizineExcretionUrine: 70–85% Feces: 10–13%1.00infobox
CetirizineFormulaC21H25ClN2O31.00infobox
CetirizineIUPHAR/BPS12221.00infobox
CetirizineKEGGD07662 Y1.00infobox
CetirizineLegal statusAU: Unscheduled1.00infobox
CetirizineLegal statusCA: OTC / Rx-only1.00infobox
CetirizineLegal statusNZ: OTC1.00infobox
CetirizineLegal statusUK: General sales list (GSL, OTC) / P1.00infobox
CetirizineLegal statusUS: OTC / Rx-only1.00infobox
CetirizineLegal statusOTC / Rx-only1.00infobox
CetirizineLicense dataUS DailyMed: Cetirizine1.00infobox
CetirizineMedlinePlusa6980261.00infobox
CetirizineMetabolismMinimal (non-cytochrome P450-mediated)1.00infobox
CetirizineMolar mass388.89 g·mol−11.00infobox
CetirizineOnset of action20–42 minutes1.00infobox
CetirizinePregnancy categoryAU: B21.00infobox
CetirizinePronunciation/sɛˈtɪrɪziːn/ ⓘ1.00infobox

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