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Complexin

Complexin (also known as synaphin) refers to a one of a small set of eukaryotic cytoplasmic neuronal proteins which binds to the SNARE protein complex (SNAREpin) with a high affinity. These are called synaphin 1 and 2. In the presence of Ca2+, the transport vesicle protein synaptotagmin displaces complexin, allowing the SNARE protein complex to bind the…

Function, Structure and Binding & Overview

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AlphaFold
IPR008849 · PF05835
Available protein structures:
IPR008849 · PF05835
InterPro
IPR008849
PDB
IPR008849 PF05835 (ECOD; PDBsum)
Pfam
PF05835
SCOP2
1l4a / SCOPe / SUPFAM

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Structure and Binding

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Map overview Semantic statistics

Complexin

Nodes26
Edges25
Triples33
Avg. degree1.92
Density0.076923
Components1

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Complexin

Top relations

related to Complexin Acts to Inhibit Fusion - Fusion Clamping · 9
Complexin → C-terminal, If, In, Inhibition, It, N-terminal, Recent, SNARE, This
related to Structure and Binding · 4
Complexin → C-terminal, Complexin's, It, SNARE
related to Complexin Acts to Promote Fusion · 3
Complexin → C-terminal, Independent, This
related to Function · 3
Complexin → By, SNARE, This
AlphaFold · 2
Complexin → IPR008849, PF05835
Available protein structures: · 2
Complexin → IPR008849, PF05835
related to Association with Synaptotagmin · 2
Complexin → Both Synaptotagmin, Synaptotagmin-1
InterPro · 1
Complexin → IPR008849
PDB · 1
Complexin → IPR008849 PF05835 (ECOD; PDBsum)
Pfam · 1
Complexin → PF05835

Important terminology Word statistics

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Important terminology

vesicle synaptotagmin fusion snare exocytosis complex synaphin synaptic protein release binds function clamping also acts promote neurotransmitter spontaneous proteins linked

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ComplexinAlphaFoldIPR0088491.00infobox
ComplexinAlphaFoldPF058351.00infobox
ComplexinAvailable protein structures:IPR0088491.00infobox
ComplexinAvailable protein structures:PF058351.00infobox
ComplexinInterProIPR0088491.00infobox
ComplexinPDBIPR008849 PF05835 (ECOD; PDBsum)1.00infobox
ComplexinPfamPF058351.00infobox
ComplexinSCOP21l4a / SCOPe / SUPFAM1.00infobox
ComplexinSymbolSynaphin1.00infobox
a depolarizing stimulus arriving at the synapseinstance ofThis dual-functionality is dependent upon synaptic activity0.80text
that of the ready releasable poolinstance ofcomplexin concentration levels regulate vesicle pool size0.80text
important for short term response changes.Complexin Acts to Inhibit Fusion - Fusion ClampingInhibition of fusion is necessary to prevent spontaneous exocytosis of vesicles into the synapseinstance ofcomplexin concentration levels regulate vesicle pool size0.80text

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    Min side: 3
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