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Complexin: Function, Structure and Binding & Overview

Complexin (also known as synaphin) refers to a one of a small set of eukaryotic cytoplasmic neuronal proteins which binds to the SNARE protein complex (SNAREpin) with a high affinity. These are called synaphin 1 and 2. In the presence of Ca2+, the transport vesicle protein synaptotagmin displaces complexin, allowing the SNARE protein complex to bind the…

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Complexin topic overview

The analysis highlights Function, Structure and Binding and Overview as prominent areas in the source structure around Complexin.

Related topics
22
Source areas
3
Connected nodes
25
Extracted relationships
33
Concept neighborhoods
15
Bridge connections
25

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 11 topics
Function · 7 topics
Structure and Binding · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR008849 · PF05835
Available protein structures:
IPR008849 · PF05835
InterPro
IPR008849
PDB
IPR008849 PF05835 (ECOD; PDBsum)
Pfam
PF05835
SCOP2
1l4a / SCOPe / SUPFAM

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure and Binding

Function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Complexin connects Entity context

The extracted context around Complexin shows recurring relationship patterns in the source. For example, Complexin → C-terminal, If, In, Inhibition, It, N-terminal, Recent, SNARE, This Another extracted example is Complexin → C-terminal, Complexin's, It, SNARE. Use these groups to spot repeated connection types before inspecting the individual relationships.

Complexin

Top relations

related to Complexin Acts to Inhibit Fusion - Fusion Clamping · 9
Complexin → C-terminal, If, In, Inhibition, It, N-terminal, Recent, SNARE, This
related to Structure and Binding · 4
Complexin → C-terminal, Complexin's, It, SNARE
related to Complexin Acts to Promote Fusion · 3
Complexin → C-terminal, Independent, This
related to Function · 3
Complexin → By, SNARE, This
AlphaFold · 2
Complexin → IPR008849, PF05835
Available protein structures: · 2
Complexin → IPR008849, PF05835
related to Association with Synaptotagmin · 2
Complexin → Both Synaptotagmin, Synaptotagmin-1
InterPro · 1
Complexin → IPR008849
PDB · 1
Complexin → IPR008849 PF05835 (ECOD; PDBsum)
Pfam · 1
Complexin → PF05835

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

vesicle synaptotagmin fusion snare exocytosis complex synaphin synaptic protein release binds function clamping also acts promote neurotransmitter spontaneous proteins linked

Complexin relationships Subject–Predicate–Object triples

TTTA extracted 33 structured relationships around Complexin. Examples in this analysis include Complexin → AlphaFold → IPR008849 and Complexin → AlphaFold → PF05835. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ComplexinAlphaFoldIPR0088491.00infobox
ComplexinAlphaFoldPF058351.00infobox
ComplexinAvailable protein structures:IPR0088491.00infobox
ComplexinAvailable protein structures:PF058351.00infobox
ComplexinInterProIPR0088491.00infobox
ComplexinPDBIPR008849 PF05835 (ECOD; PDBsum)1.00infobox
ComplexinPfamPF058351.00infobox
ComplexinSCOP21l4a / SCOPe / SUPFAM1.00infobox
ComplexinSymbolSynaphin1.00infobox
a depolarizing stimulus arriving at the synapseinstance ofThis dual-functionality is dependent upon synaptic activity0.80text
that of the ready releasable poolinstance ofcomplexin concentration levels regulate vesicle pool size0.80text
important for short term response changes.Complexin Acts to Inhibit Fusion - Fusion ClampingInhibition of fusion is necessary to prevent spontaneous exocytosis of vesicles into the synapseinstance ofcomplexin concentration levels regulate vesicle pool size0.80text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Complexin bring nearby vocabulary together. In this analysis, examples include Snare, Complex and Vesicle. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Complexin
    • Snare
    • Complex
    • Vesicle
    • Fusion
    • Exocytosis
    • Synaptotagmin
    • Binds
    • Clamping
    • Function
    • Acts
    • Binding
    • C-terminal
  • complexin
    • Snare
    • Complex
    • Vesicle
    • Fusion
    • Exocytosis
    • Synaptotagmin
    • Binds
    • Clamping
    • Function
    • Acts
    • Binding
    • C-terminal
  • snare protein complex
    • Snare
    • Small
    • Synaphin
    • Protein
    • Structure
    • Complexin
    • Allowing
    • Membrane
    • Snarepin
    • Synaptotagmin
    • Neuronal
    • Acts
  • synaptic vesicle
    • Neurotransmitter
    • Synaptic
    • Vesicle
    • Release
    • Complexin
    • Fusion
    • Allowing
    • Inhibitor
    • Acts
    • Clamp
    • Levels
    • Promoter
  • vesicle fusion
    • Synaptic
    • Release
    • Binding
    • Promote
    • Complexin
    • Fusion
    • Vesicle
    • Allowing
    • Inhibitor
    • Neurotransmitter
    • Acts
    • Clamp
  • snare complex
    • Snare
    • Protein
    • Complexin
    • Synaptotagmin
    • Neuronal
    • Small
    • Acts
    • Binding
    • Complexin's
    • Proteins
    • Synaphin
    • Vesicle
  • vesicle
    • Synaptic
    • Release
    • Complexin
    • Fusion
    • Allowing
    • Inhibitor
    • Neurotransmitter
    • Acts
    • Clamp
    • Levels
    • Promoter
    • Spontaneous
  • synaptotagmin
    • Allowing
    • Membrane
    • Binding
    • Calcium
    • Fusion
    • Clamping
    • Vesicle
    • Structure
    • Acts
    • Clamp
    • Complexin's
    • Levels

Connections between topic areas Semantic bridges

For Complexin, one of the stronger structural bridges in this analysis connects Complexin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Complexin — Overview · splits 14 ⟂ 12
Complexin — Function · splits 18 ⟂ 8
Complexin — Structure and Binding · splits 21 ⟂ 5

Map overview Semantic statistics

Complexin

Nodes26
Edges25
Triples33
Avg. degree1.92
Density0.076923
Components1

Source & methodology

TTTA analyzes the structure around Complexin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Structure and Binding & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Complexin · EN edition · Analysis: TopicsToTalkAbout

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