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UBR5

E3 ubiquitin-protein ligase UBR5 is an enzyme that in humans is encoded by the UBR5 gene.

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Interactions

InteractCIB1Karyopherin alpha 1MAPK1TOPBP1
5 related topics

Function

Autism spectrum disorder
1 related topics

Overview

EnzymeGene
2 related topics

Key facts & relationships

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2.3.2.26
↗
Aliases
UBR5, DD5, EDD, EDD1, HYD, ubiquitin protein ligase E3 component n-recognin 5
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1I2T, 2QHO, 3PT3
Band
8q22.3 · 15|15 B3.1
Bgee
ventricular zone · sural nerve · ganglionic eminence · epithelium of colon · Achilles tendon
BioGPS
n/a

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Map overview Semantic statistics

UBR5

Nodes12
Edges11
Triples110
Avg. degree1.83
Density0.166667
Components1

How this topic connects Entity context

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UBR5

Top relations

Gene ontology · 29
UBR5 → cell population proliferation, cellular response to DNA damage stimulus, cytosol, DNA repair, membrane, metal ion binding, negative regulation of double-strand break repair, negative regulation of histone H2A K63-linked ubiquitination, nucleoplasm, nucleus, perinuclear region of cytoplasm, positive regulation of canonical Wnt signaling pathway, positive regulation of gene expression, positive regulation of protein import into nucleus, progesterone receptor signaling pathway, protein binding, protein K48-linked ubiquitination, protein polyubiquitination, protein ubiquitination, protein-containing complex
Bgee · 19
UBR5 → Achilles tendon, cumulus cell, epithelium of colon, ganglionic eminence, gastric mucosa, genital tubercle, left testis, neural layer of retina, otic placode, otic vesicle, right testis, saccule, skin of abdomen, skin of leg, spermatid, spermatocyte, sural nerve, tail of embryo, ventricular zone
RNA expression pattern · 19
UBR5 → Achilles tendon, cumulus cell, epithelium of colon, ganglionic eminence, gastric mucosa, genital tubercle, left testis, neural layer of retina, otic placode, otic vesicle, right testis, saccule, skin of abdomen, skin of leg, spermatid, spermatocyte, sural nerve, tail of embryo, ventricular zone
related to External links · 8
UBR5 → E3, O95071, PDB, PDBe-KB, Protein Overview, UCSD-Nature Molecule Pages Archived, UniProt, Wayback MachineOverview
related to Function · 6
UBR5 → E3, E6-AP, HECT, Mutations, The HECT, This
related to Interactions · 3
UBR5 → CIB1, Karyopherin, MAPK1
Band · 2
UBR5 → 15|15 B3.1, 8q22.3
Chr. · 2
UBR5 → Chromosome 15 (mouse), Chromosome 8 (human)
End · 2
UBR5 → 102,412,759 bp, 38,079,098 bp
2.3.2.26 · 1
UBR5 → ↗

Important terminology Word statistics

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Important terminology

gene bp chr human band chromosome ligase e3 ubiquitin-protein protein location function enzyme mouse external pdb uniprot o95071 ubiquitin component

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
UBR52.3.2.26↗1.00infobox
UBR5AliasesUBR5, DD5, EDD, EDD1, HYD, ubiquitin protein ligase E3 component n-recognin 51.00infobox
UBR5Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1I2T, 2QHO, 3PT31.00infobox
UBR5Band8q22.31.00infobox
UBR5Band15|15 B3.11.00infobox
UBR5Bgeeventricular zone1.00infobox
UBR5Bgeesural nerve1.00infobox
UBR5Bgeeganglionic eminence1.00infobox
UBR5Bgeeepithelium of colon1.00infobox
UBR5BgeeAchilles tendon1.00infobox
UBR5Bgeeleft testis1.00infobox
UBR5Bgeegastric mucosa1.00infobox
UBR5Bgeeright testis1.00infobox
UBR5Bgeeskin of abdomen1.00infobox
UBR5Bgeeskin of leg1.00infobox
UBR5Bgeegenital tubercle1.00infobox
UBR5Bgeetail of embryo1.00infobox
UBR5Bgeesaccule1.00infobox
UBR5Bgeespermatocyte1.00infobox
UBR5Bgeeneural layer of retina1.00infobox
UBR5Bgeeotic placode1.00infobox
UBR5Bgeespermatid1.00infobox
UBR5Bgeeotic vesicle1.00infobox
UBR5Bgeecumulus cell1.00infobox
UBR5BioGPSn/a1.00infobox
UBR5Chr.Chromosome 8 (human)1.00infobox
UBR5Chr.Chromosome 15 (mouse)1.00infobox
UBR5DatabasesNCBI: entry; OMA: entry1.00infobox
UBR5End102,412,759 bp1.00infobox
UBR5End38,079,098 bp1.00infobox

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