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Trained immunity

Trained immunity is a long-term functional modification of chromatin in cells of the innate immune system which leads to an altered response to a second, possibly unrelated, challenge. For example, the BCG vaccine leads to a reduction in childhood mortality caused by unrelated infectious agents. The term "innate immune memory" is sometimes used as a…

Measurement, Immune cells subject to training & Epigenetic reprogramming

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Immune cells subject to training

Myeloid cellsMacrophagesLipopolysaccharideCandida albicansHistone methylation
30 related topics

Epigenetic reprogramming

Epigenetic reprogrammingSTAT4
2 related topics

Overview

ChromatinInnate immune systemBCG vaccineImmune memoryMihai Netea
10 related topics

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Overview

Immune cells subject to training

Epigenetic reprogramming

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Map overview Semantic statistics

Trained immunity

Nodes46
Edges45
Triples60
Avg. degree1.96
Density0.043478
Components1

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Trained immunity

Top relations

related to NK cells and innate lymphoid cell · 18
Trained immunity → Another, For, Herpes Simplex Virus, ILC1s, ILC2, In, Influenza Virus, Lung, Ly49H, Memory, Mycobacterium, NK, NKG2C, Other, Reinfection, The, These, Toxoplasma
related to Monocytes, macrophages and dendritic cells · 15
Trained immunity → Additionally, Akt/mTor HIF1α, BCG, Candida, Cryptococcus, Krebs, M1, M2, Monocytes, Monocytes/macrophages, PRRs, The, This, Though, Trained
related to Epigenetic reprogramming · 12
Trained immunity → Additionally, Cell, DNA, H3K4me3, In, Long, RNAs, RUNX, STAT4, Subsequently, There, Trained
related to Immune cells subject to training · 10
Trained immunity → Also, Candida, CpG, Escherichia, Evidence, NK, One, Similarly, Staphylococcus, Trained
is a · 1
Trained immunity → long-term functional modification of chromatin in cells of the innate immune system which leads to an altered response to a second

Important terminology Word statistics

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Important terminology

cells immunity memory trained immune innate epigenetic response nk bcg monocytes example changes also β-glucan immunological macrophages reprogramming training vaccination

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Trained immunityis along-term functional modification of chromatin in cells of the innate immune system which leads to an altered response to a second0.90text
the DTPw vaccineinstance ofOther vaccines are also thought to induce immune training0.80text
Herpes Simplex Virus or Influenza Virus also induce memory or memory-like responsesinstance ofOther viral infections0.80text
changes in chromatin accessibilityinstance ofThere are multiple potential epigenetic mechanisms0.80text
DNA methylation or histone modificationsinstance ofThere are multiple potential epigenetic mechanisms0.80text
Trained immunityrelated to Epigenetic reprogrammingTrained0.60section
Trained immunityrelated to Epigenetic reprogrammingThere0.60section
Trained immunityrelated to Epigenetic reprogrammingDNA0.60section
Trained immunityrelated to Epigenetic reprogrammingLong0.60section
Trained immunityrelated to Epigenetic reprogrammingRNAs0.60section
Trained immunityrelated to Epigenetic reprogrammingH3K4me30.60section
Trained immunityrelated to Epigenetic reprogrammingAdditionally0.60section

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