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TIM barrel

The TIM barrel (triose-phosphate isomerase), also known as an alpha/beta barrel,: 252 is a conserved protein fold consisting of eight alpha helices (α-helices) and eight parallel beta strands (β-strands) that alternate along the peptide backbone. The structure is named after triose-phosphate isomerase, a conserved metabolic enzyme. TIM barrels are…

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AlphaFold
IPR013785
Available protein structures:
IPR013785
CATH
8tim
ECOD
2002.1.1
InterPro
IPR013785
PDB
IPR013785

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Overview

Structure

Evolution and origins

De novo TIM barrel design

Advanced semantic analysis

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Map overview Semantic statistics

TIM barrel

Nodes56
Edges55
Triples138
Avg. degree1.96
Density0.035714
Components1

How this topic connects Entity context

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TIM barrel

Top relations

related to Origin through gene duplication and domain fusion · 33
TIM barrel → An, At, C-terminal, CheY, Divergent, Functional, Further, HisA, HisAF, HisF, HisF TIM, HisF-based TIM, HisF-C, HisF-CC, HisFA TIM, Höcker, In, Interestingly, Many TIM, More
related to References · 14
TIM barrel → CC BY, Deepesh Nagarajan, ISSN, Lock-gray-alt-2, Lock-green, Lock-red-alt-2, Neha Nanajkar, PDF, Science, The TIM, This, Wikidata Q87400003, WikiJournal, Wikisource-logo
related to Structural inserts · 11
TIM barrel → Bacillus, C-terminal, Four, K219, One, PDB, R215, The, The N/C-terminal, These, TIM
related to De novo TIM barrel design · 10
TIM barrel → Although, As, In, Interestingly, Octarellin, Rossmann-like, The Octarellin, The TIM, TIM, VI
related to External links · 9
TIM barrel → Anna University, Archived, Biotechnology, Center, Retrieved, SCOP, TIM, TIM Barrel Analysis, Wayback MachineBabu MM
related to TIM barrel stabilizing elements · 9
TIM barrel → An, Class, During, One, Partially-folded, Salt, The, This, TIM
related to Topology · 9
TIM barrel → All TIM, C-terminal, In, N/C-terminals, Short, Since, The, The TIM, TIM
related to Core and pore regions · 8
TIM barrel → Due, For, However, Only, Similarly, The, These, TIM
related to Evolution from a common ancestor · 8
TIM barrel → Based, C-terminal, CATH TIM, Further, In, SCOP TIM, Similarly, TIM
related to Conserved fitness landscapes · 5
TIM barrel → Although, IGPS, The, This, TIM

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Important terminology

tim barrel barrels residues proteins β-barrel fold protein folding c-terminal domains common loops enzymes ancestor domain pdb end de novo

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TIM barrelAlphaFoldIPR0137851.00infobox
TIM barrelAvailable protein structures:IPR0137851.00infobox
TIM barrelCATH8tim1.00infobox
TIM barrelECOD2002.1.11.00infobox
TIM barrelInterProIPR0137851.00infobox
TIM barrelPDBIPR0137851.00infobox
TIM barrelPfam clanCL00361.00infobox
TIM barrelSCOP28tim / SCOPe / SUPFAM1.00infobox
TIM barrelSymbolAldolase_TIM1.00infobox
TIM barrelis aexample of a complete domain insertion0.90text
TIM barrelrelated to Conserved fitness landscapesTIM0.60section
TIM barrelrelated to Conserved fitness landscapesThis0.60section

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