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Three prime repair exonuclease 1 is an enzyme that in humans is encoded by the TREX1 gene.
The analysis highlights Clinical relevance, Homology directed DNA repair and Function as prominent areas in the source structure around TREX1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around TREX1 shows recurring relationship patterns in the source. For example, TREX1 → 3'-5' exonuclease activity, 3'-5'-exodeoxyribonuclease activity, activation of immune response, adaptive immune response, adenyl deoxyribonucleotide binding, apoptotic cell clearance, atrial cardiac muscle tissue development, blood vessel development, CD86 biosynthetic process, cellular response to DNA damage stimulus, cellular response to gamma radiation, cellular response to hydroxyurea, cellular response to interferon-beta, cellular response to organic substance, cellular response to oxidative stress, cellular response to reactive oxygen species, cellular response to type I interferon, cellular response to UV, cytoplasm, cytosol Another extracted example is TREX1 → adrenal gland, anterior pituitary, blood, bone marrow, granulocyte, lens, minor salivary glands, monocyte, muscle of thigh, muscle tissue, olfactory zone of nasal mucosa, quadriceps femoris muscle, salivary gland, skin of abdomen, skin of leg, spleen, urinary bladder, white adipose tissue. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene dna exonuclease human bp repair chr band chromosome mutations location function humans chilblain cytoplasm enzyme mouse nucleic process three
TTTA extracted 165 structured relationships around TREX1. Examples in this analysis include TREX1 → 3.1.11.2 → ↗ and TREX1 → Aliases → TREX1, AGS1, CRV, DRN3, HERNS, three prime repair exonuclease 1, RVCLS. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| TREX1 | 3.1.11.2 | ↗ | 1.00 | infobox |
| TREX1 | Aliases | TREX1, AGS1, CRV, DRN3, HERNS, three prime repair exonuclease 1, RVCLS | 1.00 | infobox |
| TREX1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2IOC, 2O4G, 2O4I, 2OA8, 3B6O, 3B6P, 3MXI, 3MXJ, 3MXM, 3U3Y, 3U6F, 4YNQ | 1.00 | infobox |
| TREX1 | Band | 3p21.31 | 1.00 | infobox |
| TREX1 | Band | 9|9 F2 | 1.00 | infobox |
| TREX1 | Bgee | olfactory zone of nasal mucosa | 1.00 | infobox |
| TREX1 | Bgee | granulocyte | 1.00 | infobox |
| TREX1 | Bgee | monocyte | 1.00 | infobox |
| TREX1 | Bgee | spleen | 1.00 | infobox |
| TREX1 | Bgee | skin of abdomen | 1.00 | infobox |
| TREX1 | Bgee | skin of leg | 1.00 | infobox |
| TREX1 | Bgee | anterior pituitary | 1.00 | infobox |
| TREX1 | Bgee | blood | 1.00 | infobox |
| TREX1 | Bgee | salivary gland | 1.00 | infobox |
| TREX1 | Bgee | minor salivary glands | 1.00 | infobox |
| TREX1 | Bgee | lens | 1.00 | infobox |
| TREX1 | Bgee | urinary bladder | 1.00 | infobox |
| TREX1 | Bgee | quadriceps femoris muscle | 1.00 | infobox |
| TREX1 | Bgee | adrenal gland | 1.00 | infobox |
| TREX1 | Bgee | bone marrow | 1.00 | infobox |
| TREX1 | Bgee | muscle tissue | 1.00 | infobox |
| TREX1 | Bgee | muscle of thigh | 1.00 | infobox |
| TREX1 | Bgee | white adipose tissue | 1.00 | infobox |
| TREX1 | BioGPS | More reference expression data | 1.00 | infobox |
| TREX1 | Chr. | Chromosome 3 (human) | 1.00 | infobox |
| TREX1 | Chr. | Chromosome 9 (mouse) | 1.00 | infobox |
| TREX1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| TREX1 | End | 48,467,645 bp | 1.00 | infobox |
| TREX1 | End | 108,888,802 bp | 1.00 | infobox |
| TREX1 | Ensembl | ENSG00000213689 | 1.00 | infobox |
The concept neighborhoods around TREX1 bring nearby vocabulary together. In this analysis, examples include Variants, Vasculopathy and Prime. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For TREX1, one of the stronger structural bridges in this analysis connects TREX1 with Clinical relevance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around TREX1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical relevance, Homology directed DNA repair & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — TREX1 · EN edition · Analysis: TopicsToTalkAbout