TREX1

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Clinical relevance

Chilblain Systemic lupus erythematosus Interferon COVID-19 Mutations

10 related topics

Homology directed DNA repair

Homology-directed DNA repair DNA damage Senescence Drosophila Vasculopathy

6 related topics

Function

Exonuclease Granzyme A Aicardi-Goutieres syndrome RVCL (Retinal Vasculopathy with Cerebral Leukodystrophy)

4 related topics

Overview

Enzyme Gene

2 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.1.11.2: ↗
Aliases: TREX1, AGS1, CRV, DRN3, HERNS, three prime repair exonuclease 1, RVCLS
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2IOC, 2O4G, 2O4I, 2OA8, 3B6O, 3B6P, 3MXI, 3MXJ, 3MXM, 3U3Y, 3U6F, 4YNQ
Band: 3p21.31 · 9|9 F2
Bgee: olfactory zone of nasal mucosa · granulocyte · monocyte · spleen · skin of abdomen
BioGPS: More reference expression data

Topics to explore

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Overview

Function

Exonuclease
Granzyme A
Aicardi-Goutieres syndrome
RVCL (Retinal Vasculopathy with Cerebral Leukodystrophy) Autosomal dominant retinal vasculopathy with cerebral leukodystrophy

Clinical relevance

Homology directed DNA repair

Homology-directed DNA repair Homology directed repair
DNA damage DNA damage (naturally occurring)
Senescence
Drosophila
Vasculopathy Peripheral vasculopathy
Leukoencephalopathy

Advanced semantic analysis

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Map overview Semantic statistics

Nodes27

Edges26

Triples165

Avg. degree1.93

Density0.074074

Components1

How this topic connects Entity context

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TREX1

Top relations

Gene ontology · 92

TREX1 → 3'-5' exonuclease activity, 3'-5'-exodeoxyribonuclease activity, activation of immune response, adaptive immune response, adenyl deoxyribonucleotide binding, apoptotic cell clearance, atrial cardiac muscle tissue development, blood vessel development, CD86 biosynthetic process, cellular response to DNA damage stimulus, cellular response to gamma radiation, cellular response to hydroxyurea, cellular response to interferon-beta, cellular response to organic substance, cellular response to oxidative stress, cellular response to reactive oxygen species, cellular response to type I interferon, cellular response to UV, cytoplasm, cytosol

Bgee · 18

TREX1 → adrenal gland, anterior pituitary, blood, bone marrow, granulocyte, lens, minor salivary glands, monocyte, muscle of thigh, muscle tissue, olfactory zone of nasal mucosa, quadriceps femoris muscle, salivary gland, skin of abdomen, skin of leg, spleen, urinary bladder, white adipose tissue

RNA expression pattern · 18

related to Clinical relevance · 8

TREX1 → COVID-19, HIV, Missense, Mutations, SARS-CoV-2, The, The TREX1, This

related to Homology directed DNA repair · 4

TREX1 → DNA, Dominant C-terminal TREX1, Drosophila, Such TREX1

Band · 2

TREX1 → 3p21.31, 9|9 F2

Chr. · 2

TREX1 → Chromosome 3 (human), Chromosome 9 (mouse)

End · 2

TREX1 → 108,888,802 bp, 48,467,645 bp

3.1.11.2 · 1

TREX1 → ↗

Aliases · 1

TREX1 → TREX1, AGS1, CRV, DRN3, HERNS, three prime repair exonuclease 1, RVCLS

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene dna exonuclease human bp repair chr band chromosome mutations location function humans chilblain cytoplasm enzyme mouse nucleic process three

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
TREX1	3.1.11.2	↗	1.00	infobox
TREX1	Aliases	TREX1, AGS1, CRV, DRN3, HERNS, three prime repair exonuclease 1, RVCLS	1.00	infobox
TREX1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2IOC, 2O4G, 2O4I, 2OA8, 3B6O, 3B6P, 3MXI, 3MXJ, 3MXM, 3U3Y, 3U6F, 4YNQ	1.00	infobox
TREX1	Band	3p21.31	1.00	infobox
TREX1	Band	9\|9 F2	1.00	infobox
TREX1	Bgee	olfactory zone of nasal mucosa	1.00	infobox
TREX1	Bgee	granulocyte	1.00	infobox
TREX1	Bgee	monocyte	1.00	infobox
TREX1	Bgee	spleen	1.00	infobox
TREX1	Bgee	skin of abdomen	1.00	infobox
TREX1	Bgee	skin of leg	1.00	infobox
TREX1	Bgee	anterior pituitary	1.00	infobox
TREX1	Bgee	blood	1.00	infobox
TREX1	Bgee	salivary gland	1.00	infobox
TREX1	Bgee	minor salivary glands	1.00	infobox
TREX1	Bgee	lens	1.00	infobox
TREX1	Bgee	urinary bladder	1.00	infobox
TREX1	Bgee	quadriceps femoris muscle	1.00	infobox
TREX1	Bgee	adrenal gland	1.00	infobox
TREX1	Bgee	bone marrow	1.00	infobox
TREX1	Bgee	muscle tissue	1.00	infobox
TREX1	Bgee	muscle of thigh	1.00	infobox
TREX1	Bgee	white adipose tissue	1.00	infobox
TREX1	BioGPS	More reference expression data	1.00	infobox
TREX1	Chr.	Chromosome 3 (human)	1.00	infobox
TREX1	Chr.	Chromosome 9 (mouse)	1.00	infobox
TREX1	Databases	NCBI: entry; OMA: entry	1.00	infobox
TREX1	End	48,467,645 bp	1.00	infobox
TREX1	End	108,888,802 bp	1.00	infobox
TREX1	Ensembl	ENSG00000213689	1.00	infobox

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