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SFRP2: Cancer & Overview
Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene. This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence…
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SFRP2 topic overview
The analysis highlights Cancer and Overview as prominent areas in the source structure around SFRP2.
Related topics
10
Source areas
2
Connected nodes
12
Extracted relationships
145
Concept neighborhoods
11
Bridge connections
12
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Overview · 7 topics
Cancer · 3 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Aliases
SFRP2, FRP-2, SARP1, SDF-5, secreted frizzled related protein 2
Band
4q31.3 · 3 E3|3 37.37 cM
Bgee
skin of arm · parietal pleura · gallbladder · vena cava · skin of thigh
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 3 (mouse)
Databases
NCBI: entry; OMA: entry
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How SFRP2 connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around SFRP2 shows recurring relationship patterns in the source. For example, SFRP2 → anterior/posterior pattern specification, apoptotic process, bone morphogenesis, branching involved in blood vessel morphogenesis, canonical Wnt signaling pathway, cardiac left ventricle morphogenesis, cartilage development, cell differentiation, cell-cell signaling, cellular response to extracellular stimulus, cellular response to X-ray, chondrocyte development, collagen fibril organization, collagen-containing extracellular matrix, convergent extension involved in axis elongation, development of primary male sexual characteristics, digestive tract morphogenesis, embryonic digit morphogenesis, endopeptidase activator activity, enzyme activator activity Another extracted example is SFRP2 → aortic valve, ascending aorta, calvaria, condyle, endocardial cushion, external carotid artery, fossa, gallbladder, hand, internal carotid artery, lactiferous duct, parietal pleura, pericardium, renal corpuscle, skin of arm, skin of hip, skin of thigh, trachea, vena cava, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
SFRP2
Top relations
Gene ontology· 83
SFRP2 → anterior/posterior pattern specification, apoptotic process, bone morphogenesis, branching involved in blood vessel morphogenesis, canonical Wnt signaling pathway, cardiac left ventricle morphogenesis, cartilage development, cell differentiation, cell-cell signaling, cellular response to extracellular stimulus, cellular response to X-ray, chondrocyte development, collagen fibril organization, collagen-containing extracellular matrix, convergent extension involved in axis elongation, development of primary male sexual characteristics, digestive tract morphogenesis, embryonic digit morphogenesis, endopeptidase activator activity, enzyme activator activity
Bgee· 20
SFRP2 → aortic valve, ascending aorta, calvaria, condyle, endocardial cushion, external carotid artery, fossa, gallbladder, hand, internal carotid artery, lactiferous duct, parietal pleura, pericardium, renal corpuscle, skin of arm, skin of hip, skin of thigh, trachea, vena cava, ventricular zone
RNA expression pattern· 20
SFRP2 → aortic valve, ascending aorta, calvaria, condyle, endocardial cushion, external carotid artery, fossa, gallbladder, hand, internal carotid artery, lactiferous duct, parietal pleura, pericardium, renal corpuscle, skin of arm, skin of hip, skin of thigh, trachea, vena cava, ventricular zone
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 145 structured relationships around SFRP2. Examples in this analysis include SFRP2 → Aliases → SFRP2, FRP-2, SARP1, SDF-5, secreted frizzled related protein 2 and SFRP2 → Band → 4q31.3. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
SFRP2
Aliases
SFRP2, FRP-2, SARP1, SDF-5, secreted frizzled related protein 2
1.00
infobox
SFRP2
Band
4q31.3
1.00
infobox
SFRP2
Band
3 E3|3 37.37 cM
1.00
infobox
SFRP2
Bgee
skin of arm
1.00
infobox
SFRP2
Bgee
parietal pleura
1.00
infobox
SFRP2
Bgee
gallbladder
1.00
infobox
SFRP2
Bgee
vena cava
1.00
infobox
SFRP2
Bgee
skin of thigh
1.00
infobox
SFRP2
Bgee
trachea
1.00
infobox
SFRP2
Bgee
skin of hip
1.00
infobox
SFRP2
Bgee
lactiferous duct
1.00
infobox
SFRP2
Bgee
pericardium
1.00
infobox
SFRP2
Bgee
ventricular zone
1.00
infobox
SFRP2
Bgee
ascending aorta
1.00
infobox
SFRP2
Bgee
aortic valve
1.00
infobox
SFRP2
Bgee
calvaria
1.00
infobox
SFRP2
Bgee
hand
1.00
infobox
SFRP2
Bgee
endocardial cushion
1.00
infobox
SFRP2
Bgee
renal corpuscle
1.00
infobox
SFRP2
Bgee
condyle
1.00
infobox
SFRP2
Bgee
fossa
1.00
infobox
SFRP2
Bgee
internal carotid artery
1.00
infobox
SFRP2
Bgee
external carotid artery
1.00
infobox
SFRP2
BioGPS
More reference expression data
1.00
infobox
SFRP2
Chr.
Chromosome 4 (human)
1.00
infobox
SFRP2
Chr.
Chromosome 3 (mouse)
1.00
infobox
SFRP2
Databases
NCBI: entry; OMA: entry
1.00
infobox
SFRP2
End
153,789,083 bp
1.00
infobox
SFRP2
End
83,681,623 bp
1.00
infobox
SFRP2
Ensembl
ENSG00000145423
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around SFRP2 bring nearby vocabulary together. In this analysis, examples include External, Via and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
protein
Sfrp2
External
Secreted
Location
Gene
Chromosome
Human
Bp
Chr
Encoded
Humans
Cancer
gene
Location
Protein
Chromosome
Human
Sfrp2
Bp
Chr
Cancer
Cervical
Domain
E3
End
wnt signaling
Signaling
Wnt
Cervical
Domain
E3
End
External
Lesions
Preneoplastic
Uterine
Via
Location
human papillomavirus
Chromosome
Chr
Location
Band
E3
End
Mouse
Protein
Sfrp2
Cervical
Lesions
Preneoplastic
SFRP2
External
Via
Location
Chromosome
Human
Bp
Chr
Cervical
E3
End
Lesions
Preneoplastic
sfrp2
External
Via
Location
Chromosome
Human
Bp
Chr
Cervical
E3
End
Lesions
Preneoplastic
colorectal cancer
Methylation
External
Frizzled
Marker
Potential
Secreted
Gene
Location
Protein
Chromosome
Human
Sfrp2
cancer
Methylation
External
Frizzled
Marker
Potential
Secreted
Gene
Location
Protein
Chromosome
Human
Sfrp2
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For SFRP2, one of the stronger structural bridges in this analysis connects SFRP2 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
SFRP2
Nodes13
Edges12
Triples145
Avg. degree1.85
Density0.153846
Components1
Source & methodology
TTTA analyzes the structure around SFRP2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Cancer & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — SFRP2 · EN edition · Analysis: TopicsToTalkAbout
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