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Synaptotagmin

Synaptotagmins (SYTs) constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B. There are 17 isoforms in the mammalian synaptotagmin family. There are several C2-domain containing protein families that are related to…

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Key facts & relationships

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Membranome
199
OPM protein
3hn8
OPM superfamily
45
Symbol
SYT

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Overview

Functions

C-terminal C2-domains

Plasticity and Learning

Other important roles

Members

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Map overview Semantic statistics

Synaptotagmin

Nodes62
Edges61
Triples83
Avg. degree1.97
Density0.032258
Components1

How this topic connects Entity context

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Synaptotagmin

Top relations

related to C-terminal C2-domains · 28
Synaptotagmin → C2, C2A, C2B, Ca2, Consistent, D172, D178, D230, D232, D238, D303, D309, D363, D371, For, In, NMR, Not, Nuclear, PKC
related to Members · 17
Synaptotagmin → SYT1, SYT10, SYT11, SYT12, SYT13, SYT14, SYT15, SYT16, SYT17, SYT2, SYT3, SYT4, SYT5, SYT6, SYT7, SYT8, SYT9
related to Functions · 10
Synaptotagmin → Although, Based, C2, Ca2, Calcium-binding, In, Synaptotagmins Syt1, Syt2, Syt9, The
related to Other important roles · 8
Synaptotagmin → Apart, BD, Bipolar, Knockout, Suppression, Synaptotagmins, Syt7, This
related to Plasticity and Learning · 8
Synaptotagmin → AMPA, LTP, Moreover, Synaptotagmins, Syt1, Syt7, The, This
related to External links · 4
Synaptotagmin → Medicine Medical Subject Headings, MeSH, National Library, Synaptotagmins
Membranome · 1
Synaptotagmin → 199
OPM protein · 1
Synaptotagmin → 3hn8
OPM superfamily · 1
Synaptotagmin → 45
Symbol · 1
Synaptotagmin → SYT

Important terminology Word statistics

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Important terminology

synaptotagmins calcium domain exocytosis ca2 c2 bind binding domains c2b proteins syt1 residues c2a membrane release protein snap-25 synaptotagmin-1 family

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SynaptotagminMembranome1991.00infobox
SynaptotagminOPM protein3hn81.00infobox
SynaptotagminOPM superfamily451.00infobox
SynaptotagminSymbolSYT1.00infobox
increasing the affinity of synaptotagmin for syntaxin.The C2B domain binds to phosphatidylinositolinstance ofprotein interactions of synaptotagmin0.80text
Syt1instance ofSynaptotagmins0.80text
Syt7 also play a role in calcium-dependent AMPA receptors exocytosis to the neuron membraneinstance ofSynaptotagmins0.80text
lysosomesinstance ofOther important rolesSynaptotagmins have been shown to regulate exocytosis in other intracellular organelles0.80text
Synaptotagminrelated to C-terminal C2-domainsThe C20.60section
Synaptotagminrelated to C-terminal C2-domainsPKC0.60section
Synaptotagminrelated to C-terminal C2-domainsSubsequent0.60section
Synaptotagminrelated to C-terminal C2-domainsC20.60section

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