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Synaptotagmin: Members, Regions & Standards
Synaptotagmins (SYTs) constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B. There are 17 isoforms in the mammalian synaptotagmin family. There are several C2-domain containing protein families that are related to…
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Synaptotagmin topic overview
The analysis highlights Members, Regions and Standards as prominent areas in the source structure around Synaptotagmin. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.
Related topics
47
Source areas
6
Connected nodes
54
Extracted relationships
69
Related term clusters
36
Bridge connections
54
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Overview · 12 topics
C-terminal C2-domains · 11 topics
Functions · 10 topics
Members · 10 topics
Other important roles · 3 topics
Plasticity and Learning · 2 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Membranome
199
OPM protein
3hn8
OPM superfamily
45
Symbol
SYT
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Advanced semantic analysis
How Synaptotagmin connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around Synaptotagmin shows recurring relationship patterns in the source. For example, Synaptotagmin → C2, C2A, C2B, Ca2, Consistent, D172, D178, D230, D232, D238, D303, D309, D363, D371, NMR, Nuclear, PKC, R233, S235, Subsequent Another extracted example is Synaptotagmin → SYT1, SYT10, SYT11, SYT12, SYT13, SYT14, SYT15, SYT16, SYT17, SYT2, SYT3, SYT4, SYT5, SYT6, SYT7, SYT8, SYT9. Use these groups to spot repeated connection types before inspecting the individual relationships.
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 69 structured relationships around Synaptotagmin. Examples in this analysis include Synaptotagmin → Membranome → 199 and Synaptotagmin → OPM protein → 3hn8. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
Synaptotagmin
Membranome
199
1.00
infobox
Synaptotagmin
OPM protein
3hn8
1.00
infobox
Synaptotagmin
OPM superfamily
45
1.00
infobox
Synaptotagmin
Symbol
SYT
1.00
infobox
increasing the affinity of synaptotagmin for syntaxin.The C2B domain binds to phosphatidylinositol
instance of
protein interactions of synaptotagmin
0.80
text
Syt1
instance of
Synaptotagmins
0.80
text
Syt7 also play a role in calcium-dependent AMPA receptors exocytosis to the neuron membrane
instance of
Synaptotagmins
0.80
text
lysosomes
instance of
Other important rolesSynaptotagmins have been shown to regulate exocytosis in other intracellular organelles
0.80
text
Synaptotagmin
related to C-terminal C2-domains
The C2
0.60
section
Synaptotagmin
related to C-terminal C2-domains
PKC
0.60
section
Synaptotagmin
related to C-terminal C2-domains
Subsequent
0.60
section
Synaptotagmin
related to C-terminal C2-domains
C2
0.60
section
No triples extracted yet.
Related concept clusters Related term clusters
Related term clusters group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around Synaptotagmin bring nearby vocabulary together. In this analysis, examples include Complex, Snare and Exocytosis. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
c2 domains
Domains
Bind
Calcium
Domain
Loops
Top
C2a
Synaptotagmins
C2b
Residues
Synaptotagmin-1
Synaptobrevin
exocytosis
Complex
Snare
Fusion
Syt7
Synaptotagmins
Synaptotagmin
Synaptobrevin
Neurotransmitter
Sensor
Syntaxin
Sensors
Snap-25
voltage-gated calcium channels
Bind
Synaptotagmins
Residues
Binding
Domains
Synaptotagmin-1
Domain
Loops
Top
Complex
Snap-25
Snare
synaptotagmin 7 (syt7)
Syt1
Complex
Exocytosis
Snare
Membrane
Syntaxin
Also
Proteins
Release
Fusion
Synaptotagmin
Syt7
Synaptotagmin
Complex
Snare
Exocytosis
Syntaxin
Fusion
Syt7
Syt1
Calcium
Synaptobrevin
Neurotransmitter
Synaptotagmins
Sensors
synaptotagmin
Complex
Snare
Exocytosis
Syntaxin
Fusion
Syt7
Syt1
Calcium
Synaptobrevin
Neurotransmitter
Synaptotagmins
Sensors
c-terminal
Synaptobrevin
Neurotransmitter
Sensor
Syntaxin
Transmembrane
Complex
Domains
Family
Sensors
Snap-25
Snare
C2
synaptotagmin 2 (syt2)
Complex
Snare
Exocytosis
Syntaxin
Fusion
Syt7
Syt1
Calcium
Synaptobrevin
Neurotransmitter
Synaptotagmins
Sensors
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For Synaptotagmin, one of the stronger structural bridges in this analysis connects Synaptotagmin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
Synaptotagmin
Nodes55
Edges54
Triples69
Avg. degree1.96
Density0.036364
Components1
Source & methodology
TTTA analyzes the structure around Synaptotagmin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Members, Regions & Standards, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
