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Synaptopathy

A synaptopathy is a disease of the brain, spinal cord or peripheral nervous system relating to the dysfunction of synapses. This can arise as a result of a mutation in a gene encoding a synaptic protein such as an ion channel, neurotransmitter receptor, or a protein involved in neurotransmitter release. It can also arise as a result of an autoantibody…

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Synaptopathy

Nodes26
Edges25
Triples7
Avg. degree1.92
Density0.076923
Components1

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Synaptopathy

Top relations

is a · 1
Synaptopathy → disease of the brain

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Important terminology

synaptic also dysfunction synaptopathies result example excitotoxicity ion synapses disease system arise protein channel neurotransmitter involved release ataxia affect function

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Synaptopathyis adisease of the brain0.90text
an ion channelinstance ofThis can arise as a result of a mutation in a gene encoding a synaptic protein0.80text
neurotransmitter receptorinstance ofThis can arise as a result of a mutation in a gene encoding a synaptic protein0.80text
or a protein involved in neurotransmitter releaseinstance ofThis can arise as a result of a mutation in a gene encoding a synaptic protein0.80text
Alzheimer'sinstance ofSynaptic dysfunction can also occur in neurodegenerative disorders0.80text
in FXS result in varying degrees of cellularinstance ofAge-related cochlear synaptic and neural degeneration has also been demonstrated in mice.Molecules such as FMRP1 act as translational repressor thus when ablated0.80text
behavioural abnormalitiesinstance ofAge-related cochlear synaptic and neural degeneration has also been demonstrated in mice.Molecules such as FMRP1 act as translational repressor thus when ablated0.80text

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