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SUFU

Suppressor of fused homolog is a protein that in humans is encoded by the SUFU gene. In molecular biology, the protein domain suppressor of fused protein (Sufu) has an important role in the cell. The Sufu is important in negatively regulating an important signalling pathway in the cell, the Hedgehog signalling pathway (HH). This particular pathway is…

Art, Conservation & Function

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Conservation

13 related topics

Function

8 related topics

Interactions

4 related topics

Structure

4 related topics

Key facts & relationships

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Aliases
SUFU, PRO1280, SUFUH, SUFUXL, SUFU negative regulator of hedgehog signaling, JBTS32
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1M1L, 4BL8, 4BL9, 4BLA, 4BLB, 4BLD, 4KM8, 4KM9, 4KMD, 4KMH
Band
10q24.32 · 19 C3|19 38.85 cM
Bgee
skin of arm · nipple · body of tongue · vein · stromal cell of endometrium
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 19 (mouse)

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Overview

Function

Interactions

Conservation

Structure

Genes

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Map overview Semantic statistics

SUFU

Nodes49
Edges48
Triples126
Avg. degree1.96
Density0.040816
Components1

How this topic connects Entity context

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SUFU

Top relations

Gene ontology · 35
SUFU → aorta development, beta-catenin binding, ciliary base, ciliary tip, cilium, coronary vasculature development, cytoplasm, cytoplasmic sequestering of transcription factor, cytosol, determination of left/right symmetry, heart looping, multicellular organism development, negative regulation of DNA-binding transcription factor activity, negative regulation of osteoblast differentiation, negative regulation of protein import into nucleus, negative regulation of smoothened signaling pathway, negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning, negative regulation of transcription by RNA polymerase II, negative regulation of ubiquitin-dependent protein catabolic process, neural tube closure
Bgee · 20
SUFU → body of tongue, epiblast, internal globus pallidus, mucosa of pharynx, nipple, otic placode, otic vesicle, primary oocyte, saccule, saphenous vein, secondary oocyte, seminiferous tubule, skin of arm, spermatogonium, stromal cell of endometrium, synovial membrane, trigeminal ganglion, vein, yolk sac, zygote
RNA expression pattern · 20
SUFU → body of tongue, epiblast, internal globus pallidus, mucosa of pharynx, nipple, otic placode, otic vesicle, primary oocyte, saccule, saphenous vein, secondary oocyte, seminiferous tubule, skin of arm, spermatogonium, stromal cell of endometrium, synovial membrane, trigeminal ganglion, vein, yolk sac, zygote
related to Function · 10
SUFU → BCNS, GCPS, Gli, Greig, HPE3, Mutations, PTCH, SHH, The N-terminal, To
related to Conservation · 9
SUFU → Ci, Consequently, Drosophila, Gli, Hedgehog, Homologues, However, It, The
related to Structure · 4
SUFU → C-terminal, Gli/Ci, In, This
related to Interactions · 3
SUFU → GLI1, GLI3, PEX26
Band · 2
SUFU → 10q24.32, 19 C3|19 38.85 cM
Chr. · 2
SUFU → Chromosome 10 (human), Chromosome 19 (mouse)
End · 2
SUFU → 102,633,535 bp, 46,477,243 bp

Important terminology Word statistics

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Important terminology

pathway human gene protein bp chr band cell chromosome hedgehog found 10 transcription domain suppressor fused signalling development location function

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SUFUAliasesSUFU, PRO1280, SUFUH, SUFUXL, SUFU negative regulator of hedgehog signaling, JBTS321.00infobox
SUFUAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1M1L, 4BL8, 4BL9, 4BLA, 4BLB, 4BLD, 4KM8, 4KM9, 4KMD, 4KMH1.00infobox
SUFUBand10q24.321.00infobox
SUFUBand19 C3|19 38.85 cM1.00infobox
SUFUBgeeskin of arm1.00infobox
SUFUBgeenipple1.00infobox
SUFUBgeebody of tongue1.00infobox
SUFUBgeevein1.00infobox
SUFUBgeestromal cell of endometrium1.00infobox
SUFUBgeesynovial membrane1.00infobox
SUFUBgeemucosa of pharynx1.00infobox
SUFUBgeesaphenous vein1.00infobox
SUFUBgeetrigeminal ganglion1.00infobox
SUFUBgeeinternal globus pallidus1.00infobox
SUFUBgeeotic vesicle1.00infobox
SUFUBgeeseminiferous tubule1.00infobox
SUFUBgeesaccule1.00infobox
SUFUBgeeotic placode1.00infobox
SUFUBgeesecondary oocyte1.00infobox
SUFUBgeezygote1.00infobox
SUFUBgeeprimary oocyte1.00infobox
SUFUBgeespermatogonium1.00infobox
SUFUBgeeepiblast1.00infobox
SUFUBgeeyolk sac1.00infobox
SUFUBioGPSMore reference expression data1.00infobox
SUFUChr.Chromosome 10 (human)1.00infobox
SUFUChr.Chromosome 19 (mouse)1.00infobox
SUFUDatabasesNCBI: entry; OMA: entry1.00infobox
SUFUEnd102,633,535 bp1.00infobox
SUFUEnd46,477,243 bp1.00infobox

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