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SUFU: Art, Conservation & Function

Suppressor of fused homolog is a protein that in humans is encoded by the SUFU gene. In molecular biology, the protein domain suppressor of fused protein (Sufu) has an important role in the cell. The Sufu is important in negatively regulating an important signalling pathway in the cell, the Hedgehog signalling pathway (HH). This particular pathway is…

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SUFU topic overview

The analysis highlights Art, Conservation and Function as prominent areas in the source structure around SUFU.

Related topics
42
Source areas
6
Connected nodes
48
Extracted relationships
126
Concept neighborhoods
19
Bridge connections
48

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Conservation · 13 topics
Overview · 11 topics
Function · 8 topics
Interactions · 4 topics
Structure · 4 topics
Genes · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SUFU, PRO1280, SUFUH, SUFUXL, SUFU negative regulator of hedgehog signaling, JBTS32
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1M1L, 4BL8, 4BL9, 4BLA, 4BLB, 4BLD, 4KM8, 4KM9, 4KMD, 4KMH
Band
10q24.32 · 19 C3|19 38.85 cM
Bgee
skin of arm · nipple · body of tongue · vein · stromal cell of endometrium
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 19 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Conservation

Structure

Genes

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SUFU connects Entity context

The extracted context around SUFU shows recurring relationship patterns in the source. For example, SUFU → aorta development, beta-catenin binding, ciliary base, ciliary tip, cilium, coronary vasculature development, cytoplasm, cytoplasmic sequestering of transcription factor, cytosol, determination of left/right symmetry, heart looping, multicellular organism development, negative regulation of DNA-binding transcription factor activity, negative regulation of osteoblast differentiation, negative regulation of protein import into nucleus, negative regulation of smoothened signaling pathway, negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning, negative regulation of transcription by RNA polymerase II, negative regulation of ubiquitin-dependent protein catabolic process, neural tube closure Another extracted example is SUFU → body of tongue, epiblast, internal globus pallidus, mucosa of pharynx, nipple, otic placode, otic vesicle, primary oocyte, saccule, saphenous vein, secondary oocyte, seminiferous tubule, skin of arm, spermatogonium, stromal cell of endometrium, synovial membrane, trigeminal ganglion, vein, yolk sac, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

SUFU

Top relations

Gene ontology · 35
SUFU → aorta development, beta-catenin binding, ciliary base, ciliary tip, cilium, coronary vasculature development, cytoplasm, cytoplasmic sequestering of transcription factor, cytosol, determination of left/right symmetry, heart looping, multicellular organism development, negative regulation of DNA-binding transcription factor activity, negative regulation of osteoblast differentiation, negative regulation of protein import into nucleus, negative regulation of smoothened signaling pathway, negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning, negative regulation of transcription by RNA polymerase II, negative regulation of ubiquitin-dependent protein catabolic process, neural tube closure
Bgee · 20
SUFU → body of tongue, epiblast, internal globus pallidus, mucosa of pharynx, nipple, otic placode, otic vesicle, primary oocyte, saccule, saphenous vein, secondary oocyte, seminiferous tubule, skin of arm, spermatogonium, stromal cell of endometrium, synovial membrane, trigeminal ganglion, vein, yolk sac, zygote
RNA expression pattern · 20
SUFU → body of tongue, epiblast, internal globus pallidus, mucosa of pharynx, nipple, otic placode, otic vesicle, primary oocyte, saccule, saphenous vein, secondary oocyte, seminiferous tubule, skin of arm, spermatogonium, stromal cell of endometrium, synovial membrane, trigeminal ganglion, vein, yolk sac, zygote
related to Function · 10
SUFU → BCNS, GCPS, Gli, Greig, HPE3, Mutations, PTCH, SHH, The N-terminal, To
related to Conservation · 9
SUFU → Ci, Consequently, Drosophila, Gli, Hedgehog, Homologues, However, It, The
related to Structure · 4
SUFU → C-terminal, Gli/Ci, In, This
related to Interactions · 3
SUFU → GLI1, GLI3, PEX26
Band · 2
SUFU → 10q24.32, 19 C3|19 38.85 cM
Chr. · 2
SUFU → Chromosome 10 (human), Chromosome 19 (mouse)
End · 2
SUFU → 102,633,535 bp, 46,477,243 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pathway human gene protein bp chr band cell chromosome hedgehog found 10 transcription domain suppressor fused signalling development location function

SUFU relationships Subject–Predicate–Object triples

TTTA extracted 126 structured relationships around SUFU. Examples in this analysis include SUFU → Aliases → SUFU, PRO1280, SUFUH, SUFUXL, SUFU negative regulator of hedgehog signaling, JBTS32 and SUFU → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1M1L, 4BL8, 4BL9, 4BLA, 4BLB, 4BLD, 4KM8, 4KM9, 4KMD, 4KMH. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SUFUAliasesSUFU, PRO1280, SUFUH, SUFUXL, SUFU negative regulator of hedgehog signaling, JBTS321.00infobox
SUFUAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1M1L, 4BL8, 4BL9, 4BLA, 4BLB, 4BLD, 4KM8, 4KM9, 4KMD, 4KMH1.00infobox
SUFUBand10q24.321.00infobox
SUFUBand19 C3|19 38.85 cM1.00infobox
SUFUBgeeskin of arm1.00infobox
SUFUBgeenipple1.00infobox
SUFUBgeebody of tongue1.00infobox
SUFUBgeevein1.00infobox
SUFUBgeestromal cell of endometrium1.00infobox
SUFUBgeesynovial membrane1.00infobox
SUFUBgeemucosa of pharynx1.00infobox
SUFUBgeesaphenous vein1.00infobox
SUFUBgeetrigeminal ganglion1.00infobox
SUFUBgeeinternal globus pallidus1.00infobox
SUFUBgeeotic vesicle1.00infobox
SUFUBgeeseminiferous tubule1.00infobox
SUFUBgeesaccule1.00infobox
SUFUBgeeotic placode1.00infobox
SUFUBgeesecondary oocyte1.00infobox
SUFUBgeezygote1.00infobox
SUFUBgeeprimary oocyte1.00infobox
SUFUBgeespermatogonium1.00infobox
SUFUBgeeepiblast1.00infobox
SUFUBgeeyolk sac1.00infobox
SUFUBioGPSMore reference expression data1.00infobox
SUFUChr.Chromosome 10 (human)1.00infobox
SUFUChr.Chromosome 19 (mouse)1.00infobox
SUFUDatabasesNCBI: entry; OMA: entry1.00infobox
SUFUEnd102,633,535 bp1.00infobox
SUFUEnd46,477,243 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SUFU bring nearby vocabulary together. In this analysis, examples include Found, Cell and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • SUFU
    • Found
    • Cell
    • Gene
    • Chromosome
    • Hedgehog
    • Human
    • Pathway
    • Homologues
    • Important
    • Molecular
    • Negative
    • Role
  • sufu
    • Found
    • Cell
    • Gene
    • Chromosome
    • Hedgehog
    • Human
    • Pathway
    • Homologues
    • Important
    • Molecular
    • Negative
    • Role
  • protein
    • Domain
    • Sufu
    • Molecular
    • Suppressor
    • Cell
    • Transcription
    • Gene
    • End
    • Important
    • Mouse
    • Negative
    • Nucleus
  • gene
    • Chromosome
    • Human
    • Location
    • Bp
    • Chr
    • End
    • Mouse
    • Negative
    • Search
    • Signaling
    • Function
    • Sufu
  • molecular biology
    • Cell
    • End
    • Important
    • Mouse
    • Negative
    • Nucleus
    • Protein
    • Role
    • Search
    • Signaling
    • Development
    • Function
  • protein domain
    • Domain
    • Protein
    • Factors
    • Gli
    • Sufu
    • Molecular
    • Transcription
    • Suppressor
    • Cell
    • Gene
    • Important
    • Role
  • cell
    • Important
    • Molecular
    • Role
    • Pathway
    • Development
    • Sufu
    • Hedgehog
    • Protein
    • Crucial
    • End
    • Mouse
    • Negative
  • signalling pathway
    • Development
    • Hedgehog
    • Crucial
    • Nucleus
    • Pathway
    • Signalling
    • Transcription
    • Sufu
    • End
    • Mouse
    • Negative
    • Particular

Connections between topic areas Semantic bridges

For SUFU, one of the stronger structural bridges in this analysis connects SUFU with Conservation. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SUFUConservation · splits 35 ⟂ 14
SUFUOverview · splits 37 ⟂ 12
SUFUFunction · splits 40 ⟂ 9
SUFUInteractions · splits 44 ⟂ 5
SUFUStructure · splits 44 ⟂ 5
SUFUGenes · splits 46 ⟂ 3

Map overview Semantic statistics

SUFU

Nodes49
Edges48
Triples126
Avg. degree1.96
Density0.040816
Components1

Source & methodology

TTTA analyzes the structure around SUFU to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Conservation & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SUFU · EN edition · Analysis: TopicsToTalkAbout

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