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Suppressor of fused homolog is a protein that in humans is encoded by the SUFU gene. In molecular biology, the protein domain suppressor of fused protein (Sufu) has an important role in the cell. The Sufu is important in negatively regulating an important signalling pathway in the cell, the Hedgehog signalling pathway (HH). This particular pathway is…
The analysis highlights Art, Conservation and Function as prominent areas in the source structure around SUFU.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around SUFU shows recurring relationship patterns in the source. For example, SUFU → aorta development, beta-catenin binding, ciliary base, ciliary tip, cilium, coronary vasculature development, cytoplasm, cytoplasmic sequestering of transcription factor, cytosol, determination of left/right symmetry, heart looping, multicellular organism development, negative regulation of DNA-binding transcription factor activity, negative regulation of osteoblast differentiation, negative regulation of protein import into nucleus, negative regulation of smoothened signaling pathway, negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning, negative regulation of transcription by RNA polymerase II, negative regulation of ubiquitin-dependent protein catabolic process, neural tube closure Another extracted example is SUFU → body of tongue, epiblast, internal globus pallidus, mucosa of pharynx, nipple, otic placode, otic vesicle, primary oocyte, saccule, saphenous vein, secondary oocyte, seminiferous tubule, skin of arm, spermatogonium, stromal cell of endometrium, synovial membrane, trigeminal ganglion, vein, yolk sac, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
pathway human gene protein bp chr band cell chromosome hedgehog found 10 transcription domain suppressor fused signalling development location function
TTTA extracted 126 structured relationships around SUFU. Examples in this analysis include SUFU → Aliases → SUFU, PRO1280, SUFUH, SUFUXL, SUFU negative regulator of hedgehog signaling, JBTS32 and SUFU → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1M1L, 4BL8, 4BL9, 4BLA, 4BLB, 4BLD, 4KM8, 4KM9, 4KMD, 4KMH. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| SUFU | Aliases | SUFU, PRO1280, SUFUH, SUFUXL, SUFU negative regulator of hedgehog signaling, JBTS32 | 1.00 | infobox |
| SUFU | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1M1L, 4BL8, 4BL9, 4BLA, 4BLB, 4BLD, 4KM8, 4KM9, 4KMD, 4KMH | 1.00 | infobox |
| SUFU | Band | 10q24.32 | 1.00 | infobox |
| SUFU | Band | 19 C3|19 38.85 cM | 1.00 | infobox |
| SUFU | Bgee | skin of arm | 1.00 | infobox |
| SUFU | Bgee | nipple | 1.00 | infobox |
| SUFU | Bgee | body of tongue | 1.00 | infobox |
| SUFU | Bgee | vein | 1.00 | infobox |
| SUFU | Bgee | stromal cell of endometrium | 1.00 | infobox |
| SUFU | Bgee | synovial membrane | 1.00 | infobox |
| SUFU | Bgee | mucosa of pharynx | 1.00 | infobox |
| SUFU | Bgee | saphenous vein | 1.00 | infobox |
| SUFU | Bgee | trigeminal ganglion | 1.00 | infobox |
| SUFU | Bgee | internal globus pallidus | 1.00 | infobox |
| SUFU | Bgee | otic vesicle | 1.00 | infobox |
| SUFU | Bgee | seminiferous tubule | 1.00 | infobox |
| SUFU | Bgee | saccule | 1.00 | infobox |
| SUFU | Bgee | otic placode | 1.00 | infobox |
| SUFU | Bgee | secondary oocyte | 1.00 | infobox |
| SUFU | Bgee | zygote | 1.00 | infobox |
| SUFU | Bgee | primary oocyte | 1.00 | infobox |
| SUFU | Bgee | spermatogonium | 1.00 | infobox |
| SUFU | Bgee | epiblast | 1.00 | infobox |
| SUFU | Bgee | yolk sac | 1.00 | infobox |
| SUFU | BioGPS | More reference expression data | 1.00 | infobox |
| SUFU | Chr. | Chromosome 10 (human) | 1.00 | infobox |
| SUFU | Chr. | Chromosome 19 (mouse) | 1.00 | infobox |
| SUFU | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| SUFU | End | 102,633,535 bp | 1.00 | infobox |
| SUFU | End | 46,477,243 bp | 1.00 | infobox |
The concept neighborhoods around SUFU bring nearby vocabulary together. In this analysis, examples include Found, Cell and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For SUFU, one of the stronger structural bridges in this analysis connects SUFU with Conservation. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around SUFU to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Conservation & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — SUFU · EN edition · Analysis: TopicsToTalkAbout