Sortilin

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Function

Brain Spinal cord Adrenal gland Thyroid B-lymphocytes

34 related topics

Structure

Exons Isoforms Alternative splicing Crystallization Ligand

15 related topics

Clinical significance

Lysosomal degradation Pathophysiology Neurological disorders Apolipoprotein E Oncology

14 related topics

Overview

Protein Gene Chromosome 1 Glycoprotein Vacuolar protein sorting

21 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: SORT1, Gp95, LDLCQ6, NT3, NTR3, Sortilin 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3F6K, 3G2U, 3G2V, 4MSL, 4N7E, 4PO7
Band: 1p13.3|1p21.3-p13.1 · 3|3 F3
Bgee: inferior ganglion of vagus nerve · corpus epididymis · subthalamic nucleus · postcentral gyrus · globus pallidus
BioGPS: More reference expression data
Chr.: Chromosome 1 (human) · Chromosome 3 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Structure

Exons Exon
Isoforms
Alternative splicing
Crystallization
Ligand
Neurotensin
Ectodomain
Binding sites Binding site
Synthesis Protein synthesis
Precursor protein Protein precursor
Amino acid
Pro-peptide Propeptide
Chaperone Chaperone (protein)
Hydrophobic loops Hydrophobic effect
Protein dimer

Function

Clinical significance

Lysosomal degradation Protein degradation
Pathophysiology
Neurological disorders Neurological disorder
Apolipoprotein E
Oncology
Cancer cell lines
Epithelial cells
Breast cancer
Cell adhesion
Genome-wide Genome-wide association study
Lipid metabolism disorders Lipid metabolism disorder
Statin
Cohort study
Randomized controlled trials Randomized controlled trial

Interactions

Interact Protein-protein interaction
GGA1
GGA2

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes93

Edges92

Triples180

Avg. degree1.98

Density0.021505

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Sortilin

Top relations

Gene ontology · 52

Sortilin → cell differentiation, cell surface, clathrin-coated pit, clathrin-coated vesicle, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, dendrite, early endosome, endocytosis, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, endosome to lysosome transport, endosome transport via multivesicular body sorting pathway, enzyme binding, extrinsic apoptotic signaling pathway via death domain receptors, G protein-coupled receptor signaling pathway, glucose import

Bgee · 20

Sortilin → aortic valve, ascending aorta, corpus callosum, corpus epididymis, dentate gyrus of hippocampal formation granule cell, external globus pallidus, globus pallidus, granulocyte, inferior ganglion of vagus nerve, internal globus pallidus, lumbar subsegment of spinal cord, muscle of thigh, neural layer of retina, pars reticulata, postcentral gyrus, primary visual cortex, spermatid, subthalamic nucleus, superior frontal gyrus, superior vestibular nucleus

RNA expression pattern · 20

related to Clinical marker · 14

Sortilin → Additionally, As, ASCOT, Cancer, CARE, In, JUPITER, Malmo Diet, PROVE IT-TIMI, Several, SORT1, Subsequently, The, This

related to Function · 14

Sortilin → As, B-lymphocytes, BDNF, GLUT4, Golgi, In, It, LDL-cholesterol, Moreover, Other, PCSK9, The, This, VLDL

related to Clinical significance · 6

Sortilin → Alzheimer's, APOE, For, Furthermore, Given, Notably

related to External links · 5

Sortilin → Overview, PDB, PDBe-KB, Q99523, UniProt

related to Protein · 5

Sortilin → Crystallization, In, To, Vps10, Vps10p

Band · 2

Sortilin → 1p13.3|1p21.3-p13.1, 3|3 F3

Chr. · 2

Sortilin → Chromosome 1 (human), Chromosome 3 (mouse)

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene protein sort1 cell human disease chromosome coronary artery bp membrane band metabolism also chr function lipid endosome receptor transport

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Sortilin	Aliases	SORT1, Gp95, LDLCQ6, NT3, NTR3, Sortilin 1	1.00	infobox
Sortilin	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3F6K, 3G2U, 3G2V, 4MSL, 4N7E, 4PO7	1.00	infobox
Sortilin	Band	1p13.3\|1p21.3-p13.1	1.00	infobox
Sortilin	Band	3\|3 F3	1.00	infobox
Sortilin	Bgee	inferior ganglion of vagus nerve	1.00	infobox
Sortilin	Bgee	corpus epididymis	1.00	infobox
Sortilin	Bgee	subthalamic nucleus	1.00	infobox
Sortilin	Bgee	postcentral gyrus	1.00	infobox
Sortilin	Bgee	globus pallidus	1.00	infobox
Sortilin	Bgee	external globus pallidus	1.00	infobox
Sortilin	Bgee	internal globus pallidus	1.00	infobox
Sortilin	Bgee	pars reticulata	1.00	infobox
Sortilin	Bgee	corpus callosum	1.00	infobox
Sortilin	Bgee	superior vestibular nucleus	1.00	infobox
Sortilin	Bgee	dentate gyrus of hippocampal formation granule cell	1.00	infobox
Sortilin	Bgee	superior frontal gyrus	1.00	infobox
Sortilin	Bgee	primary visual cortex	1.00	infobox
Sortilin	Bgee	ascending aorta	1.00	infobox
Sortilin	Bgee	granulocyte	1.00	infobox
Sortilin	Bgee	muscle of thigh	1.00	infobox
Sortilin	Bgee	lumbar subsegment of spinal cord	1.00	infobox
Sortilin	Bgee	aortic valve	1.00	infobox
Sortilin	Bgee	spermatid	1.00	infobox
Sortilin	Bgee	neural layer of retina	1.00	infobox
Sortilin	BioGPS	More reference expression data	1.00	infobox
Sortilin	Chr.	Chromosome 1 (human)	1.00	infobox
Sortilin	Chr.	Chromosome 3 (mouse)	1.00	infobox
Sortilin	Databases	NCBI: entry; OMA: entry	1.00	infobox
Sortilin	End	109,397,918 bp	1.00	infobox
Sortilin	End	108,268,827 bp	1.00	infobox

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Connections between topic areas Semantic bridges

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