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Serotonin transporter

The serotonin transporter (SERT or 5-HTT), also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4, is a protein that in humans is encoded by the SLC6A4 gene. SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic neuron, in a…

Genetics, Function & Pharmacology

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Aliases
SLC6A4, 5-HTT, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, Solute Carrier Family 6 (neurotransmitter transporter), member 4, solute carrier family 6 member 4, 5-HTTLPR
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5I6X, 5I73, 5I75, 5I6Z, 5I71, 5I74
Band
17q11.2 · 11 B5|11 46.18 cM
Bgee
right lung · jejunal mucosa · mucosa of ileum · lower lobe of lung · placenta
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

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Overview

Mechanism of action

Function

Pharmacology

Genetics

Neuroimaging

Neuroimaging and genetics

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Serotonin transporter

Nodes96
Edges95
Triples151
Avg. degree1.98
Density0.020833
Components1

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Serotonin transporter

Top relations

Gene ontology · 62
Serotonin transporter → actin filament binding, brain development, brain morphogenesis, cellular response to cGMP, cellular response to organic substance, cellular response to retinoic acid, circadian rhythm, cocaine binding, cytosol, dopamine uptake involved in synaptic transmission, dopamine:sodium symporter activity, ejaculation, endomembrane system, endosome, endosome membrane, focal adhesion, integral component of membrane, integral component of plasma membrane, integral component of postsynaptic membrane, integral component of presynaptic membrane
Bgee · 19
Serotonin transporter → adrenal gland, blood, buccal mucosa cell, central gray substance of midbrain, dorsal tegmental nucleus, duodenum, Ileal epithelium, intestinal villus, jejunal mucosa, jejunum, lower lobe of lung, mucosa of ileum, oral cavity, placenta, right lung, set of raphe nuclei of tegmentum of midbrain, superior vestibular nucleus, upper lobe of left lung, yolk sac
RNA expression pattern · 19
Serotonin transporter → adrenal gland, blood, buccal mucosa cell, central gray substance of midbrain, dorsal tegmental nucleus, duodenum, Ileal epithelium, intestinal villus, jejunal mucosa, jejunum, lower lobe of lung, mucosa of ileum, oral cavity, placenta, right lung, set of raphe nuclei of tegmentum of midbrain, superior vestibular nucleus, upper lobe of left lung, yolk sac
related to Neuroimaging · 10
Serotonin transporter → CIT, DAPP, DASB, Healthy, Journal, Neural Transmission, Revised NEO Personality Inventory, SPECT, The, There
related to Genetics · 7
Serotonin transporter → In, Mutations, SLC6A4, Solute, Some, The, These
related to Mechanism of action · 4
Serotonin transporter → In, Right, Serotonin-reuptake, The
related to Function · 3
Serotonin transporter → Neurons, The, Thus
Band · 2
Serotonin transporter → 11 B5|11 46.18 cM, 17q11.2
Chr. · 2
Serotonin transporter → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
Serotonin transporter → 30,236,002 bp, 76,923,166 bp

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Important terminology

serotonin transporter gene polymorphism 5-httlpr sert found slc6a4 binding human bp variation vntr stin2 protein 17 neurotransmitter reuptake family chr

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Serotonin transporterAliasesSLC6A4, 5-HTT, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, Solute Carrier Family 6 (neurotransmitter transporter), member 4, solute carrier family 6 member 4, 5-HTTLPR1.00infobox
Serotonin transporterAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5I6X, 5I73, 5I75, 5I6Z, 5I71, 5I741.00infobox
Serotonin transporterBand17q11.21.00infobox
Serotonin transporterBand11 B5|11 46.18 cM1.00infobox
Serotonin transporterBgeeright lung1.00infobox
Serotonin transporterBgeejejunal mucosa1.00infobox
Serotonin transporterBgeemucosa of ileum1.00infobox
Serotonin transporterBgeelower lobe of lung1.00infobox
Serotonin transporterBgeeplacenta1.00infobox
Serotonin transporterBgeeupper lobe of left lung1.00infobox
Serotonin transporterBgeeduodenum1.00infobox
Serotonin transporterBgeebuccal mucosa cell1.00infobox
Serotonin transporterBgeesuperior vestibular nucleus1.00infobox
Serotonin transporterBgeeoral cavity1.00infobox
Serotonin transporterBgeecentral gray substance of midbrain1.00infobox
Serotonin transporterBgeedorsal tegmental nucleus1.00infobox
Serotonin transporterBgeeblood1.00infobox
Serotonin transporterBgeejejunum1.00infobox
Serotonin transporterBgeeyolk sac1.00infobox
Serotonin transporterBgeeset of raphe nuclei of tegmentum of midbrain1.00infobox
Serotonin transporterBgeeadrenal gland1.00infobox
Serotonin transporterBgeeintestinal villus1.00infobox
Serotonin transporterBgeeIleal epithelium1.00infobox
Serotonin transporterBioGPSMore reference expression data1.00infobox
Serotonin transporterChr.Chromosome 17 (human)1.00infobox
Serotonin transporterChr.Chromosome 11 (mouse)1.00infobox
Serotonin transporterDatabasesNCBI: entry; OMA: entry1.00infobox
Serotonin transporterEnd30,236,002 bp1.00infobox
Serotonin transporterEnd76,923,166 bp1.00infobox
Serotonin transporterEnsemblENSG000001085761.00infobox

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