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Infliximab

Infliximab, a chimeric monoclonal antibody, sold under the brand name Remicade among others, is a medication used to treat a number of autoimmune diseases. This includes Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, and Behçet's disease. It is given by slow injection into a vein…

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Key facts & relationships

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AHFS/Drugs.com
Monograph
ATC code
L04AB02 (WHO)
Bioavailability
92% (IV, if 8% left in the syringe)
Biosimilars
infliximab-abda, infliximab-axxq, infliximab-dyyb, infliximab-qbtx, Avsola, Flixabi, Inflectra, Ixifi, Remsima, Renflexis, Zessly, Zymfentra
CAS Number
170277-31-3 Y
ChEMBL
ChEMBL1201581 N

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Overview

Medical uses

Adverse effects

Pharmacology

History

Society and culture

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Map overview Semantic statistics

Infliximab

Nodes94
Edges93
Triples91
Avg. degree1.98
Density0.021277
Components1

How this topic connects Entity context

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Infliximab

Top relations

related to Ulcerative colitis · 12
Infliximab → ACT1, ACT2, At, Colitis Treatment, However, Paul Rutgeerts, Th1, Th2, The Acute, TNF, Ulcerative, William Sandborn
related to history · 10
Infliximab → Centocor, George Kollias, Inc, Jan Vilček, Janssen Biotech, Junming Le, Medicine, New York University School, The, TNF
related to Psoriatic arthritis · 10
Infliximab → Among, AS, Based, In, NSAID, PsA, Results, Several, The, TNF
related to Availability/affordability · 9
Infliximab → CDAI, Crohn's, For, In, NHS, Patients, Since February, The, UK
has effect · 6
Infliximab → Breactivation, Enbrel, Humira, Some, T-cell, TNF-inhibiting
related to Pharmacology · 6
Infliximab → Additionally, DNA-derived, Etanercept, IgG, It, TNF
Legal status · 5
Infliximab → AU: S4 (Prescription only), CA: ℞-only / Schedule D, EU: Rx-only, UK: POM (Prescription only), US: ℞-only
is a · 3
Infliximab → chimeric monoclonal antibody biologic, most frequently used biological agent in treating relapsing polychondritis, therapeutic alternative on the World Health Organization's List of Essential Medicines..mw-parser-output .toclimit-2 .toclevel-1 ul
related to External links · 3
Infliximab → Media, Wikimedia Commons, Wiktionary-logo-en-v2
related to Other · 2
Infliximab → Behçet's, It

Important terminology Word statistics

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Important terminology

approved disease tnf patients treatment antibody use crohn's monoclonal chimeric psoriasis mouse colitis arthritis european united states human ulcerative medical

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
InfliximabAHFS/Drugs.comMonograph1.00infobox
InfliximabATC codeL04AB02 (WHO)1.00infobox
InfliximabBioavailability92% (IV, if 8% left in the syringe)1.00infobox
InfliximabBiosimilarsinfliximab-abda, infliximab-axxq, infliximab-dyyb, infliximab-qbtx, Avsola, Flixabi, Inflectra, Ixifi, Remsima, Renflexis, Zessly, Zymfentra1.00infobox
InfliximabCAS Number170277-31-3 Y1.00infobox
InfliximabChEMBLChEMBL1201581 N1.00infobox
InfliximabChemSpidernone1.00infobox
InfliximabCompTox Dashboard (EPA)DTXSID90405041.00infobox
InfliximabDrugBankDB00065 Y1.00infobox
InfliximabElimination half-life9.5 days1.00infobox
InfliximabFormulaC6428H9912N1694O1987S461.00infobox
InfliximabKEGGD02598 Y1.00infobox
InfliximabLegal statusAU: S4 (Prescription only)1.00infobox
InfliximabLegal statusCA: ℞-only / Schedule D1.00infobox
InfliximabLegal statusUK: POM (Prescription only)1.00infobox
InfliximabLegal statusUS: ℞-only1.00infobox
InfliximabLegal statusEU: Rx-only1.00infobox
InfliximabLicense dataUS DailyMed: Infliximab1.00infobox
InfliximabMedlinePlusa6040231.00infobox
InfliximabMetabolismreticuloendothelial system1.00infobox
InfliximabMolar mass144190.64 g·mol−11.00infobox
InfliximabPregnancy categoryAU: C1.00infobox
InfliximabRoutes of administrationIntravenous, subcutaneous1.00infobox
InfliximabSourceChimeric (mouse/human)1.00infobox
InfliximabTargetTumor necrosis factors (TNF)1.00infobox
InfliximabTrade namesRemicade, others1.00infobox
InfliximabTypeWhole antibody1.00infobox
InfliximabUNIIB72HH48FLU1.00infobox
Infliximabis achimeric monoclonal antibody biologic0.90text
Infliximabis atherapeutic alternative on the World Health Organization's List of Essential Medicines..mw-parser-output .toclimit-2 .toclevel-1 ul0.90text

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