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Etanercept

Etanercept, sold under the brand name Enbrel among others, is a biologic medical product that is used to treat autoimmune diseases by interfering with tumor necrosis factor (TNF), a soluble inflammatory cytokine, by acting as a TNF inhibitor. It has US Food and Drug Administration (FDA) approval to treat rheumatoid arthritis, juvenile idiopathic…

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Key facts & relationships

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AHFS/Drugs.com
Monograph
ATC code
L04AB01 (WHO)
Bioavailability
58–76% (SC)
Biosimilars
etanercept-szzs, etanercept-ykro, Benepali, Brenzys, Erelzi, Etacept, Etera, Eticovo, Fubelv, Lifmior, Nepexto, Rymti
CAS Number
185243-69-0
ChEMBL
ChEMBL1201572

Topics to explore

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Overview

Medical uses

Adverse effects

Mechanism of action

History

Society and culture

Advanced semantic analysis

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Map overview Semantic statistics

Etanercept

Nodes57
Edges56
Triples115
Avg. degree1.96
Density0.035088
Components1

How this topic connects Entity context

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Etanercept

Top relations

related to history · 14
Etanercept → Another, Beutler, Brian Seed, Bruce, Dallas, Immmunex, Immunex, Massachusetts General Hospital, November, September, Texas Southwestern Medical Center, The, United States, University
related to Medical uses · 12
Etanercept → Ankylosing, April, AS, In, January, July, May, Moderate, November, Psoriatic, RA, United States
related to Economics · 11
Etanercept → As, By, Canada, Health Plans, IFHP, In, International Federation, Switzerland, The IFHP, The US, US
related to Unrecognized uses · 11
Etanercept → American Academy, An American, Edward Tobinick, Neurology, Novella, Of, Science-Based Medicine, Steven Novella, Tobinick, US, Writing
related to Patents · 10
Etanercept → As, Before, Biologics Price Competition, European Union, However, Innovation Act, Many, October, The, United States
has effect · 7
Etanercept → Drug Administration, FDA, Injection, May, On, Serious, US Food
related to Structure · 6
Etanercept → Fc, IgG1, N-glycans, O-glycans, The, TNF
Legal status · 5
Etanercept → AU: S4 (Prescription only), CA: ℞-only / Schedule D, EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Mechanism of action · 4
Etanercept → Inhibition, It, TNF, Tumor
is a · 3
Etanercept → complex molecule containing 6 N-glycans, fusion protein produced by recombinant DNA, therapeutic alternative on the World Health Organization's List of Essential Medicines

Important terminology Word statistics

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Important terminology

tnf us protein use receptor dna diseases igg1 approved response fusion fc medical european union soluble treat autoimmune immune first

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
EtanerceptAHFS/Drugs.comMonograph1.00infobox
EtanerceptATC codeL04AB01 (WHO)1.00infobox
EtanerceptBioavailability58–76% (SC)1.00infobox
EtanerceptBiosimilarsetanercept-szzs, etanercept-ykro, Benepali, Brenzys, Erelzi, Etacept, Etera, Eticovo, Fubelv, Lifmior, Nepexto, Rymti1.00infobox
EtanerceptCAS Number185243-69-01.00infobox
EtanerceptChEMBLChEMBL12015721.00infobox
EtanerceptChemSpiderNone1.00infobox
EtanerceptCompTox Dashboard (EPA)DTXSID80408501.00infobox
EtanerceptDrugBankDB000051.00infobox
EtanerceptECHA InfoCard100.224.3831.00infobox
EtanerceptElimination half-life70–132 hours1.00infobox
EtanerceptFormulaC2224H3475N621O698S361.00infobox
EtanerceptKEGGD007421.00infobox
EtanerceptLegal statusAU: S4 (Prescription only)1.00infobox
EtanerceptLegal statusCA: ℞-only / Schedule D1.00infobox
EtanerceptLegal statusUK: POM (Prescription only)1.00infobox
EtanerceptLegal statusUS: ℞-only1.00infobox
EtanerceptLegal statusEU: Rx-only1.00infobox
EtanerceptLicense dataUS DailyMed: Etanercept1.00infobox
EtanerceptMedlinePlusa6020131.00infobox
EtanerceptMolar mass51235.07 g·mol−11.00infobox
EtanerceptPregnancy categoryAU: D1.00infobox
EtanerceptPubChem SID78478071.00infobox
EtanerceptRoutes of administrationSubcutaneous1.00infobox
EtanerceptTrade namesEnbrel1.00infobox
EtanerceptUNIIOP401G7OJC1.00infobox
Etanerceptis afusion protein produced by recombinant DNA0.90text
Etanerceptis atherapeutic alternative on the World Health Organization's List of Essential Medicines0.90text
Etanerceptis acomplex molecule containing 6 N-glycans0.90text

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