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RAPGEF3

Rap guanine nucleotide exchange factor 3 also known as exchange factor directly activated by cAMP 1 (EPAC1) or cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI) is a protein that in humans is encoded by the RAPGEF3 gene.

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Aliases
RAPGEF3, CAMP-GEFI, EPAC, EPAC1, HSU79275, bcm910, Rap guanine nucleotide exchange factor 3
Band
12q13.11 · 15|15 F1
Bgee
right lobe of thyroid gland · apex of heart · right ovary · left lobe of thyroid gland · left ovary
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 15 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

History and discovery

Gene

Protein family

Protein structure and mechanism of activation

Clinical relevance

Pharmacological agonists and antagonists

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Map overview Semantic statistics

RAPGEF3

Nodes50
Edges49
Triples116
Avg. degree1.96
Density0.04
Components1

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RAPGEF3

Top relations

Gene ontology · 34
RAPGEF3 → angiogenesis, cAMP binding, cAMP-mediated signaling, cell population proliferation, cellular response to cAMP, cortical actin cytoskeleton, endomembrane system, establishment of endothelial barrier, extracellular exosome, filopodium, guanyl-nucleotide exchange factor activity, intracellular anatomical structure, intracellular signal transduction, lamellipodium, membrane, microvillus, negative regulation of syncytium formation by plasma membrane fusion, nucleotide binding, plasma membrane, positive regulation of angiogenesis
Bgee · 20
RAPGEF3 → aortic valve, apex of heart, ascending aorta, canal of the cervix, ciliary body, ectocervix, iris, left lobe of thyroid gland, left ovary, motor neuron, renal cortex, retinal pigment epithelium, right kidney, right lobe of thyroid gland, right ovary, right uterine tube, Rostral migratory stream, sural nerve, tendon of biceps brachii, vestibular membrane of cochlear duct
RNA expression pattern · 20
RAPGEF3 → aortic valve, apex of heart, ascending aorta, canal of the cervix, ciliary body, ectocervix, iris, left lobe of thyroid gland, left ovary, motor neuron, renal cortex, retinal pigment epithelium, right kidney, right lobe of thyroid gland, right ovary, right uterine tube, Rostral migratory stream, sural nerve, tendon of biceps brachii, vestibular membrane of cochlear duct
related to history · 16
RAPGEF3 → CNG, De Rooij, EPAC, GEFI, GEFII, GEFs, HCN, Kawasaki, PKA, PKA-dependent, Rap1, Ras, Since, The, This, While
related to Gene · 6
RAPGEF3 → EPAC1a, EPAC1b, Human RAPGEF3, NCBI, Out, While
Band · 2
RAPGEF3 → 12q13.11, 15|15 F1
Chr. · 2
RAPGEF3 → Chromosome 12 (human), Chromosome 15 (mouse)
End · 2
RAPGEF3 → 47,771,040 bp, 97,767,972 bp
Aliases · 1
RAPGEF3 → RAPGEF3, CAMP-GEFI, EPAC, EPAC1, HSU79275, bcm910, Rap guanine nucleotide exchange factor 3
BioGPS · 1
RAPGEF3 → More reference expression data

Important terminology Word statistics

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Important terminology

epac1 camp epac protein gene human bp nucleotide rap proteins exchange epac2 chr band functions also chromosome 12 family cellular

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
RAPGEF3AliasesRAPGEF3, CAMP-GEFI, EPAC, EPAC1, HSU79275, bcm910, Rap guanine nucleotide exchange factor 31.00infobox
RAPGEF3Band12q13.111.00infobox
RAPGEF3Band15|15 F11.00infobox
RAPGEF3Bgeeright lobe of thyroid gland1.00infobox
RAPGEF3Bgeeapex of heart1.00infobox
RAPGEF3Bgeeright ovary1.00infobox
RAPGEF3Bgeeleft lobe of thyroid gland1.00infobox
RAPGEF3Bgeeleft ovary1.00infobox
RAPGEF3Bgeetendon of biceps brachii1.00infobox
RAPGEF3Bgeeright uterine tube1.00infobox
RAPGEF3Bgeesural nerve1.00infobox
RAPGEF3Bgeecanal of the cervix1.00infobox
RAPGEF3Bgeeectocervix1.00infobox
RAPGEF3Bgeeaortic valve1.00infobox
RAPGEF3Bgeemotor neuron1.00infobox
RAPGEF3Bgeeascending aorta1.00infobox
RAPGEF3Bgeeretinal pigment epithelium1.00infobox
RAPGEF3Bgeeciliary body1.00infobox
RAPGEF3Bgeeright kidney1.00infobox
RAPGEF3Bgeevestibular membrane of cochlear duct1.00infobox
RAPGEF3Bgeeiris1.00infobox
RAPGEF3BgeeRostral migratory stream1.00infobox
RAPGEF3Bgeerenal cortex1.00infobox
RAPGEF3BioGPSMore reference expression data1.00infobox
RAPGEF3Chr.Chromosome 12 (human)1.00infobox
RAPGEF3Chr.Chromosome 15 (mouse)1.00infobox
RAPGEF3DatabasesNCBI: entry; OMA: entry1.00infobox
RAPGEF3End47,771,040 bp1.00infobox
RAPGEF3End97,767,972 bp1.00infobox
RAPGEF3EnsemblENSG000000793371.00infobox

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