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Rap guanine nucleotide exchange factor 3 also known as exchange factor directly activated by cAMP 1 (EPAC1) or cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI) is a protein that in humans is encoded by the RAPGEF3 gene.
The analysis highlights History, Clinical relevance and History and discovery as prominent areas in the source structure around RAPGEF3.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around RAPGEF3 shows recurring relationship patterns in the source. For example, RAPGEF3 → angiogenesis, cAMP binding, cAMP-mediated signaling, cell population proliferation, cellular response to cAMP, cortical actin cytoskeleton, endomembrane system, establishment of endothelial barrier, extracellular exosome, filopodium, guanyl-nucleotide exchange factor activity, intracellular anatomical structure, intracellular signal transduction, lamellipodium, membrane, microvillus, negative regulation of syncytium formation by plasma membrane fusion, nucleotide binding, plasma membrane, positive regulation of angiogenesis Another extracted example is RAPGEF3 → aortic valve, apex of heart, ascending aorta, canal of the cervix, ciliary body, ectocervix, iris, left lobe of thyroid gland, left ovary, motor neuron, renal cortex, retinal pigment epithelium, right kidney, right lobe of thyroid gland, right ovary, right uterine tube, Rostral migratory stream, sural nerve, tendon of biceps brachii, vestibular membrane of cochlear duct. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
epac1 camp epac protein gene human bp nucleotide rap proteins exchange epac2 chr band functions also chromosome 12 family cellular
TTTA extracted 116 structured relationships around RAPGEF3. Examples in this analysis include RAPGEF3 → Aliases → RAPGEF3, CAMP-GEFI, EPAC, EPAC1, HSU79275, bcm910, Rap guanine nucleotide exchange factor 3 and RAPGEF3 → Band → 12q13.11. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| RAPGEF3 | Aliases | RAPGEF3, CAMP-GEFI, EPAC, EPAC1, HSU79275, bcm910, Rap guanine nucleotide exchange factor 3 | 1.00 | infobox |
| RAPGEF3 | Band | 12q13.11 | 1.00 | infobox |
| RAPGEF3 | Band | 15|15 F1 | 1.00 | infobox |
| RAPGEF3 | Bgee | right lobe of thyroid gland | 1.00 | infobox |
| RAPGEF3 | Bgee | apex of heart | 1.00 | infobox |
| RAPGEF3 | Bgee | right ovary | 1.00 | infobox |
| RAPGEF3 | Bgee | left lobe of thyroid gland | 1.00 | infobox |
| RAPGEF3 | Bgee | left ovary | 1.00 | infobox |
| RAPGEF3 | Bgee | tendon of biceps brachii | 1.00 | infobox |
| RAPGEF3 | Bgee | right uterine tube | 1.00 | infobox |
| RAPGEF3 | Bgee | sural nerve | 1.00 | infobox |
| RAPGEF3 | Bgee | canal of the cervix | 1.00 | infobox |
| RAPGEF3 | Bgee | ectocervix | 1.00 | infobox |
| RAPGEF3 | Bgee | aortic valve | 1.00 | infobox |
| RAPGEF3 | Bgee | motor neuron | 1.00 | infobox |
| RAPGEF3 | Bgee | ascending aorta | 1.00 | infobox |
| RAPGEF3 | Bgee | retinal pigment epithelium | 1.00 | infobox |
| RAPGEF3 | Bgee | ciliary body | 1.00 | infobox |
| RAPGEF3 | Bgee | right kidney | 1.00 | infobox |
| RAPGEF3 | Bgee | vestibular membrane of cochlear duct | 1.00 | infobox |
| RAPGEF3 | Bgee | iris | 1.00 | infobox |
| RAPGEF3 | Bgee | Rostral migratory stream | 1.00 | infobox |
| RAPGEF3 | Bgee | renal cortex | 1.00 | infobox |
| RAPGEF3 | BioGPS | More reference expression data | 1.00 | infobox |
| RAPGEF3 | Chr. | Chromosome 12 (human) | 1.00 | infobox |
| RAPGEF3 | Chr. | Chromosome 15 (mouse) | 1.00 | infobox |
| RAPGEF3 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| RAPGEF3 | End | 47,771,040 bp | 1.00 | infobox |
| RAPGEF3 | End | 97,767,972 bp | 1.00 | infobox |
| RAPGEF3 | Ensembl | ENSG00000079337 | 1.00 | infobox |
The concept neighborhoods around RAPGEF3 bring nearby vocabulary together. In this analysis, examples include Small, Specific and Cellular. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For RAPGEF3, one of the stronger structural bridges in this analysis connects RAPGEF3 with Clinical relevance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around RAPGEF3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Clinical relevance & History and discovery, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — RAPGEF3 · EN edition · Analysis: TopicsToTalkAbout