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PLA2G4A: Function, Interactions & Clinical significance

Cytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene.

Language: English [EN]
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PLA2G4A topic overview

The analysis highlights Function, Interactions and Clinical significance as prominent areas in the source structure around PLA2G4A.

Related topics
22
Source areas
4
Connected nodes
26
Extracted relationships
105
Concept neighborhoods
14
Bridge connections
26

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 17 topics
Interactions · 2 topics
Overview · 2 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.1.1.4
3.1.1.5
Aliases
PLA2G4A, PLA2G4, cPLA2-alpha, cPLA2, phospholipase A2 group IVA, GURDP
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BCI, 1CJY, 1RLW
Band
1q31.1 · 1 G1|1 63.51 cM
Bgee
seminal vesicula · cartilage tissue · right uterine tube · urinary bladder · caput epididymis

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PLA2G4A connects Entity context

The extracted context around PLA2G4A shows recurring relationship patterns in the source. For example, PLA2G4A → arachidonic acid metabolic process, arachidonic acid secretion, calcium ion binding, calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding, cardiolipin acyl-chain remodeling, cellular response to antibiotic, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, glycerophospholipid catabolic process, Golgi apparatus, hydrolase activity, icosanoid biosynthetic process, icosanoid metabolic process, lipid catabolic process, lipid droplet, lipid metabolism Another extracted example is PLA2G4A → Achilles tendon, caput epididymis, cartilage tissue, cervix, cumulus cell, epithelium of lens, epithelium of stomach, gastrula, germinal epithelium, iris, jejunal mucosa, mucosa of urinary bladder, mucous cell of stomach, Paneth cell, parietal pleura, right uterine tube, seminal vesicula, transitional epithelium of urinary bladder, urinary bladder, urothelium. Use these groups to spot repeated connection types before inspecting the individual relationships.

PLA2G4A

Top relations

Gene ontology · 38
PLA2G4A → arachidonic acid metabolic process, arachidonic acid secretion, calcium ion binding, calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding, cardiolipin acyl-chain remodeling, cellular response to antibiotic, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, glycerophospholipid catabolic process, Golgi apparatus, hydrolase activity, icosanoid biosynthetic process, icosanoid metabolic process, lipid catabolic process, lipid droplet, lipid metabolism
Bgee · 20
PLA2G4A → Achilles tendon, caput epididymis, cartilage tissue, cervix, cumulus cell, epithelium of lens, epithelium of stomach, gastrula, germinal epithelium, iris, jejunal mucosa, mucosa of urinary bladder, mucous cell of stomach, Paneth cell, parietal pleura, right uterine tube, seminal vesicula, transitional epithelium of urinary bladder, urinary bladder, urothelium
RNA expression pattern · 20
PLA2G4A → Achilles tendon, caput epididymis, cartilage tissue, cervix, cumulus cell, epithelium of lens, epithelium of stomach, gastrula, germinal epithelium, iris, jejunal mucosa, mucosa of urinary bladder, mucous cell of stomach, Paneth cell, parietal pleura, right uterine tube, seminal vesicula, transitional epithelium of urinary bladder, urinary bladder, urothelium
Band · 2
PLA2G4A → 1 G1|1 63.51 cM, 1q31.1
Chr. · 2
PLA2G4A → Chromosome 1 (human), Chromosome 1 (mouse)
End · 2
PLA2G4A → 149,837,041 bp, 186,988,981 bp
3.1.1.4 · 1
PLA2G4A → ↗
3.1.1.5 · 1
PLA2G4A → ↗
Aliases · 1
PLA2G4A → PLA2G4A, PLA2G4, cPLA2-alpha, cPLA2, phospholipase A2 group IVA, GURDP
Available structures · 1
PLA2G4A → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BCI, 1CJY, 1RLW

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp gene chr human band phospholipase a2 chromosome enzyme location mouse cytosolic membrane function search activity 988 981 end 186

PLA2G4A relationships Subject–Predicate–Object triples

TTTA extracted 105 structured relationships around PLA2G4A. Examples in this analysis include PLA2G4A → 3.1.1.4 → ↗ and PLA2G4A → Aliases → PLA2G4A, PLA2G4, cPLA2-alpha, cPLA2, phospholipase A2 group IVA, GURDP. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PLA2G4A3.1.1.41.00infobox
PLA2G4A3.1.1.51.00infobox
PLA2G4AAliasesPLA2G4A, PLA2G4, cPLA2-alpha, cPLA2, phospholipase A2 group IVA, GURDP1.00infobox
PLA2G4AAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BCI, 1CJY, 1RLW1.00infobox
PLA2G4ABand1q31.11.00infobox
PLA2G4ABand1 G1|1 63.51 cM1.00infobox
PLA2G4ABgeeseminal vesicula1.00infobox
PLA2G4ABgeecartilage tissue1.00infobox
PLA2G4ABgeeright uterine tube1.00infobox
PLA2G4ABgeeurinary bladder1.00infobox
PLA2G4ABgeecaput epididymis1.00infobox
PLA2G4ABgeemucosa of urinary bladder1.00infobox
PLA2G4ABgeegerminal epithelium1.00infobox
PLA2G4ABgeeAchilles tendon1.00infobox
PLA2G4ABgeeparietal pleura1.00infobox
PLA2G4ABgeejejunal mucosa1.00infobox
PLA2G4ABgeeepithelium of lens1.00infobox
PLA2G4ABgeemucous cell of stomach1.00infobox
PLA2G4ABgeeurothelium1.00infobox
PLA2G4ABgeecervix1.00infobox
PLA2G4ABgeeepithelium of stomach1.00infobox
PLA2G4ABgeetransitional epithelium of urinary bladder1.00infobox
PLA2G4ABgeePaneth cell1.00infobox
PLA2G4ABgeecumulus cell1.00infobox
PLA2G4ABgeegastrula1.00infobox
PLA2G4ABgeeiris1.00infobox
PLA2G4ABioGPSMore reference expression data1.00infobox
PLA2G4AChr.Chromosome 1 (human)1.00infobox
PLA2G4AChr.Chromosome 1 (mouse)1.00infobox
PLA2G4ADatabasesNCBI: entry; OMA: entry1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PLA2G4A bring nearby vocabulary together. In this analysis, examples include Search, Location and Acid. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • enzyme
    • Membrane
    • Phospholipase
    • Pla2g4a
    • Gene
    • Clinical
    • Encoded
    • Humans
    • Interactions
    • Acid
    • Activity
    • Arachidonic
    • Cytosol
  • gene
    • Location
    • Phospholipase
    • Chromosome
    • Human
    • Pla2g4a
    • Bp
    • Chr
    • Activity
    • End
    • Function
    • G1
    • Group
  • cytosolic
    • A2
    • Phospholipase
    • Encoded
    • Humans
    • Pla2g4a
    • Gene
    • Acid
    • Activity
    • Arachidonic
    • Cellular
    • Cytosol
    • End
  • phospholipase a2
    • Phospholipase
    • Pla2g4a
    • Activity
    • Cytosolic
    • Function
    • Group
    • Search
    • Gene
    • Location
    • Chromosome
    • Enzyme
    • Human
  • arachidonic acid
    • Acid
    • Arachidonic
    • Membrane
    • Activity
    • Cellular
    • Cytosol
    • Cytosolic
    • Eicosanoids
    • End
    • Factor
    • Function
    • G1
  • function
    • Activity
    • Group
    • Search
    • Location
    • Phospholipase
    • Chromosome
    • Clinical
    • Human
    • Interactions
    • Pla2g4a
    • Bp
    • Chr
  • clinical significance
    • Interactions
    • Activity
    • Function
    • Group
    • Search
    • Location
    • Phospholipase
    • Chromosome
    • Enzyme
    • Human
    • Pla2g4a
    • Bp
  • PLA2G4A
    • Search
    • Location
    • Acid
    • Arachidonic
    • Cellular
    • Cytosol
    • End
    • Factor
    • G1
    • Mouse
    • Nucleus
    • Membrane

Connections between topic areas Semantic bridges

For PLA2G4A, one of the stronger structural bridges in this analysis connects PLA2G4A with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PLA2G4AFunction · splits 9 ⟂ 18
PLA2G4AOverview · splits 24 ⟂ 3
PLA2G4AInteractions · splits 24 ⟂ 3

Map overview Semantic statistics

PLA2G4A

Nodes27
Edges26
Triples105
Avg. degree1.93
Density0.074074
Components1

Source & methodology

TTTA analyzes the structure around PLA2G4A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PLA2G4A · EN edition · Analysis: TopicsToTalkAbout

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