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Pikromycin

Pikromycin was studied by Brokmann and Hekel in 1951 and was the first antibiotic macrolide to be isolated. Pikromycin is synthesized through a type I polyketide synthase system in Streptomyces venezuelae, a species of Gram-positive bacterium in the genus Streptomyces. Pikromycin is derived from narbonolide, a 14-membered ring macrolide. Along with the…

Standards, Biosynthesis & Overview

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Overview

Biosynthesis

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Pikromycin

Nodes13
Edges12
Triples32
Avg. degree1.85
Density0.153846
Components1

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Pikromycin

Top relations

related to Biosynthesis · 30
Pikromycin → ACP, AT, Des, DesI-DesVI, DesI-DesVIII, DesVII, DesVIII, DH, ER, Figure, II, In Figure, KR, KS, KSQ, P450, PikAI, PikAII, PikAIII, PikAIV

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Important terminology

narbonolide synthase macrolide streptomyces polyketide venezuelae antibiotic references pks type bacterium desosamine sugar used standard state biosynthesis thioesterase gram-positive erythromycins

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
erythromycinsinstance ofit can be used as a raw material to synthesize antibiotic ketolide compounds0.80text
new epothilonesinstance ofit can be used as a raw material to synthesize antibiotic ketolide compounds0.80text
Pikromycinrelated to BiosynthesisThe0.60section
Pikromycinrelated to BiosynthesisStreptomyces0.60section
Pikromycinrelated to BiosynthesisPikAI0.60section
Pikromycinrelated to BiosynthesisPikAII0.60section
Pikromycinrelated to BiosynthesisPikAIII0.60section
Pikromycinrelated to BiosynthesisPikAIV0.60section
Pikromycinrelated to BiosynthesisThese0.60section
Pikromycinrelated to BiosynthesisRecently0.60section
Pikromycinrelated to BiosynthesisPKS0.60section
Pikromycinrelated to BiosynthesisIn Figure0.60section

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