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Epothilone

Epothilones are a class of potential cancer drugs. Like taxanes, they prevent cancer cells from dividing by interfering with tubulin, but in early trials, epothilones have better efficacy and milder adverse effects than taxanes.

History, Applications, Research & Measurement

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Overview

History

Mechanism of action

Medical use and research

Total synthesis

Biosynthesis

Advanced semantic analysis

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Map overview Semantic statistics

Epothilone

Nodes73
Edges72
Triples58
Avg. degree1.97
Density0.027397
Components1

How this topic connects Entity context

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Epothilone

Top relations

related to Biosynthesis · 23
Epothilone → ACP, As, AT, Dehydratase, DH, Enoyl Reductase, EPOS, ER, Figure, In, Ketoreductase, KR, KSQ, N-methylation, NRPS, Once, PKS, PKS-I, S-PCP, The
related to Total synthesis · 14
Epothilone → Carreira, Danishefsky, Due, Epoxidation, Figure, Grubbs, In, Mulzer, Nicolaou, One, Other, Schinzer, The, This
related to Mechanism of action · 11
Epothilone → At, Finally, Furthermore, G2-M, GTP, It, Like, Microtubules, Once, The, This
related to Medical use and research · 9
Epothilone → China, Drug Administration, EMEA, III, In November, October, One, United States Food, Utidelone
related to history · 1
Epothilone → The

Important terminology Word statistics

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Important terminology

cancer epothilones aldehyde paclitaxel microtubule pks epos total also mechanism patupilone phase figure nrps like synthesis taxanes formation breast one

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Epothilonerelated to BiosynthesisThe0.60section
Epothilonerelated to BiosynthesisPKS0.60section
Epothilonerelated to BiosynthesisNRPS0.60section
Epothilonerelated to BiosynthesisIn0.60section
Epothilonerelated to BiosynthesisKetoreductase0.60section
Epothilonerelated to BiosynthesisKR0.60section
Epothilonerelated to BiosynthesisDehydratase0.60section
Epothilonerelated to BiosynthesisDH0.60section
Epothilonerelated to BiosynthesisEnoyl Reductase0.60section
Epothilonerelated to BiosynthesisER0.60section
Epothilonerelated to BiosynthesisPKS-I0.60section
Epothilonerelated to BiosynthesisUnlike PKS0.60section

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    Min side: 3
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