Apixaban

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Apixaban topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Apixaban.

Related topics: 57
Source areas: 6
Connected nodes: 63
Extracted relationships: 92
Concept neighborhoods: 24
Bridge connections: 63

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 19 topics

Medical uses · 16 topics

Side effects · 10 topics

Society and culture · 9 topics

Mechanism of action · 2 topics

History · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol): Interactive image
AHFS/Drugs.com: Monograph
ATC code: B01AF02 (WHO)
Bioavailability: ~50%
CAS Number: 503612-47-3 Y
ChEMBL: ChEMBL231779 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Anticoagulant
Blood clots Venous thromboembolism
Stroke
Atrial fibrillation
Factor Xa
Warfarin
Hip Hip replacement
Knee replacement
By mouth Oral administration
Bleeding
Bleeding around the spine Spinal hematoma
Pregnancy
Breastfeeding
Kidney problems
Interactions with other medications Drug interaction
Direct factor Xa inhibitor
Pfizer
Bristol-Myers Squibb Bristol Myers Squibb
World Health Organization's List of Essential Medicines WHO Model List of Essential Medicines

Medical uses

Side effects

Antiplatelet medications Antiplatelet medication
Selective serotonin reuptake inhibitors Selective serotonin reuptake inhibitor
Serotonin-norepinephrine reuptake inhibitors Serotonin–norepinephrine reuptake inhibitor
Nonsteroidal anti-inflammatory drugs Nonsteroidal anti-inflammatory drug
Andexanet alfa
Food and Drug Administration
Antidote
Hematoma
Catheters Catheter
Hemostasis

Mechanism of action

History

New drug application

Society and culture

Mylan
Patent infringement
Sigmapharm Sigma Pharmaceutical Group
Unichem Unichem Laboratories
Federal Circuit Court Federal Circuit Court of Appeals
Apotex Inc.
Inflation Reduction Act
Centers for Medicare & Medicaid Services
Medicare Medicare (United States)

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Apixaban connects Entity context

The extracted context around Apixaban shows recurring relationship patterns in the source. For example, Apixaban → Apotex Inc, August, BMS, Canadian, Federal Circuit Court, In December, In July, In September, Micro Labs, Mylan, Pfizer, Sigmapharm, Sunshine Lake, The, Unichem, United States, US FDA Another extracted example is Apixaban → ARISTOTLE, BMS, BMS-562247-01, Bristol-Myers Squibb, By, December, Drug Administration, During, European Union, FDA, In August, In March, May, NDA, Pfizer, US Food. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Economics · 17

Apixaban → Apotex Inc, August, BMS, Canadian, Federal Circuit Court, In December, In July, In September, Micro Labs, Mylan, Pfizer, Sigmapharm, Sunshine Lake, The, Unichem, United States, US FDA

related to history · 16

Apixaban → ARISTOTLE, BMS, BMS-562247-01, Bristol-Myers Squibb, By, December, Drug Administration, During, European Union, FDA, In August, In March, May, NDA, Pfizer, US Food

related to Bleeding · 12

Apixaban → Andexanet, ARISTOTLE, Bleeding, Drug Administration, FDA, In, Large, NSAIDs, SNRIs, SSRIs, The, US Food

related to Medical uses · 7

Apixaban → DVT, For, PE, The, To, Treatment, VTE

Legal status · 6

Apixaban → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only

related to Atrial fibrillation · 6

Apixaban → CHA2DS2-VASc, Clinical Excellence, Compared, DOACs, Health, National Institute

related to Mechanism of action · 2

Apixaban → Factor Xa, Xa

3D model (JSmol) · 1

Apixaban → Interactive image

AHFS/Drugs.com · 1

Apixaban → Monograph

ATC code · 1

Apixaban → B01AF02 (WHO)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bleeding people embolism risk may use stroke atrial fibrillation approved factor xa united states warfarin side us pfizer direct blood

Apixaban relationships Subject–Predicate–Object triples

TTTA extracted 92 structured relationships around Apixaban. Examples in this analysis include Apixaban → 3D model (JSmol) → Interactive image and Apixaban → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Apixaban	3D model (JSmol)	Interactive image	1.00	infobox
Apixaban	AHFS/Drugs.com	Monograph	1.00	infobox
Apixaban	ATC code	B01AF02 (WHO)	1.00	infobox
Apixaban	Bioavailability	~50%	1.00	infobox
Apixaban	CAS Number	503612-47-3 Y	1.00	infobox
Apixaban	ChEMBL	ChEMBL231779 Y	1.00	infobox
Apixaban	ChemSpider	8358471 Y	1.00	infobox
Apixaban	CompTox Dashboard (EPA)	DTXSID80436500	1.00	infobox
Apixaban	DrugBank	DB07828 Y	1.00	infobox
Apixaban	ECHA InfoCard	100.167.332	1.00	infobox
Apixaban	Elimination half-life	9–14 h	1.00	infobox
Apixaban	Excretion	Bile duct (75%), kidney (25%)	1.00	infobox
Apixaban	Formula	C25H25N5O4	1.00	infobox
Apixaban	IUPHAR/BPS	6390	1.00	infobox
Apixaban	KEGG	D03213 Y	1.00	infobox
Apixaban	Legal status	AU: S4 (Prescription only)	1.00	infobox
Apixaban	Legal status	CA: ℞-only	1.00	infobox
Apixaban	Legal status	UK: POM (Prescription only)	1.00	infobox
Apixaban	Legal status	US: ℞-only	1.00	infobox
Apixaban	Legal status	EU: Rx-only	1.00	infobox
Apixaban	Legal status	In general: ℞ (Prescription only)	1.00	infobox
Apixaban	License data	US DailyMed: Apixaban	1.00	infobox
Apixaban	MedlinePlus	a613032	1.00	infobox
Apixaban	Metabolism	CYP3A4, CYP3A5, CYP1A2 and others	1.00	infobox
Apixaban	Molar mass	459.506 g·mol−1	1.00	infobox
Apixaban	Other names	BMS-562247-01	1.00	infobox
Apixaban	Pregnancy category	AU: C	1.00	infobox
Apixaban	Protein binding	~87%	1.00	infobox
Apixaban	PubChem CID	10182969	1.00	infobox
Apixaban	Routes of administration	By mouth	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Apixaban bring nearby vocabulary together. In this analysis, examples include People, Atrial and Fibrillation. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Apixaban
- People
- Atrial
- Fibrillation
- Stroke
- Approved
- Us
- Embolism
- May
- Risk
- Systemic
- Direct
- Bleeding
apixaban
- People
- Atrial
- Fibrillation
- Stroke
- Approved
- Us
- Embolism
- May
- Risk
- Systemic
- Direct
- Bleeding
stroke
- Systemic
- People
- Embolism
- Prevention
- Risk
- Effects
- Kidney
- Medical
- Used
- Clinical
- December
- Deep
atrial fibrillation
- Fibrillation
- Stroke
- Systemic
- People
- Embolism
- Prevention
- Eliquis
- Risk
- Effects
- Kidney
- Medical
- Medication
non-valvular atrial fibrillation
- Fibrillation
- Stroke
- Systemic
- People
- Embolism
- Prevention
- Eliquis
- Risk
- Effects
- Kidney
- Medical
- Medication
embolism
- Pulmonary
- Systemic
- Fibrillation
- Stroke
- Deep
- Treatment
- Vein
- People
- Thrombosis
- Hip
- Knee
- Prevention
pulmonary embolism
- Treatment
- Vein
- Pulmonary
- Systemic
- Thrombosis
- Fibrillation
- Stroke
- Deep
- People
- Replacement
- Hip
- Knee
deep vein thrombosis
- Deep
- Vein
- Thrombosis
- Hip
- Knee
- Pulmonary
- Replacement
- Treatment
- Embolism
- Prevention
- Approved
- Systemic

Connections between topic areas Semantic bridges

For Apixaban, one of the stronger structural bridges in this analysis connects Apixaban with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Apixaban — Overview · splits 44 ⟂ 20

Apixaban — Medical uses · splits 47 ⟂ 17

Apixaban — Side effects · splits 53 ⟂ 11

Apixaban — Society and culture · splits 54 ⟂ 10

Apixaban — Mechanism of action · splits 61 ⟂ 3

Map overview Semantic statistics

Apixaban

Nodes64

Edges63

Triples92

Avg. degree1.97

Density0.03125

Components1

Source & methodology

TTTA analyzes the structure around Apixaban to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Apixaban · EN edition · Analysis: TopicsToTalkAbout