Perlecan

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Perlecan topic overview

The analysis highlights Cultures, Structure and Function as prominent areas in the source structure around Perlecan.

Related topics: 78
Source areas: 8
Connected nodes: 86
Extracted relationships: 240
Concept neighborhoods: 27
Bridge connections: 86

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 18 topics

Overview · 17 topics

Function · 14 topics

Degradation · 8 topics

Modification of glycosaminoglycan chains · 8 topics

Disease association · 7 topics

Interactions · 5 topics

Expression · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: HSPG2, HSPG, PLC, PRCAN, SJA, SJS, SJS1, heparan sulfate proteoglycan 2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3SH4, 3SH5
Band: 1p36.12 · 4 D3|4 69.93 cM
Bgee: saphenous vein · popliteal artery · tibial arteries · thoracic aorta · Descending thoracic aorta
BioGPS: More reference expression data
Chr.: Chromosome 1 (human) · Chromosome 4 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Modification of glycosaminoglycan chains

Degradation

Expression

Corneal fibroblasts

Disease association

Nude mice
Epithelial-mesenchymal transition
Diabetes
Atherosclerosis
Arthritis
Diabetic albuminuria Diabetic albuminuria?action=edit&redlink=1
Schwartz–Jampel syndrome

Interactions

Interact Protein–protein interaction
FBLN2
FGF7
FGFBP1
Transthyretin

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Perlecan connects Entity context

The extracted context around Perlecan shows recurring relationship patterns in the source. For example, Perlecan → amyloid-beta binding, angiogenesis, animal organ morphogenesis, basement membrane, brain development, calcium ion binding, cell differentiation, cell migration, collagen-containing extracellular matrix, extracellular exosome, extracellular matrix, extracellular matrix disassembly, extracellular matrix organization, extracellular matrix structural constituent conferring compression resistance, extracellular region, extracellular space, focal adhesion, glycosaminoglycan biosynthetic process, glycosaminoglycan catabolic process, glycosaminoglycan metabolic process Another extracted example is Perlecan → Although HS, CS, DGSDE, Domain, Domain II, Domain III, Domain IV, HS, HS/CS, HSPG2, IG, IV, IVa, IVb, LDL, Removal, The, The C-terminal Domain, The N-terminal, Thus. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 35

Perlecan → amyloid-beta binding, angiogenesis, animal organ morphogenesis, basement membrane, brain development, calcium ion binding, cell differentiation, cell migration, collagen-containing extracellular matrix, extracellular exosome, extracellular matrix, extracellular matrix disassembly, extracellular matrix organization, extracellular matrix structural constituent conferring compression resistance, extracellular region, extracellular space, focal adhesion, glycosaminoglycan biosynthetic process, glycosaminoglycan catabolic process, glycosaminoglycan metabolic process

related to Structure · 20

Perlecan → Although HS, CS, DGSDE, Domain, Domain II, Domain III, Domain IV, HS, HS/CS, HSPG2, IG, IV, IVa, IVb, LDL, Removal, The, The C-terminal Domain, The N-terminal, Thus

Bgee · 19

Perlecan → ankle, ascending aorta, Descending thoracic aorta, external carotid artery, genital tubercle, internal carotid artery, left coronary artery, lip, molar, muscle layer of sigmoid colon, muscle of thigh, popliteal artery, right coronary artery, right ventricle, saphenous vein, thoracic aorta, tibial arteries, tibial nerve, tibiofemoral joint

RNA expression pattern · 19

related to Cancer · 18

Perlecan → By, Cancer, ECM, GAG, II, III, In, MeWo, MeWo/70W, More, One, RT101, Since, The, They, This, Thus, While Perlecan

related to Degradation · 13

Perlecan → Addition, Although Whitelock, Another, Cathepsin, Cells, ECM, FGF, FGF-10, FGF-positive, HS-bound, Specific, The, This

related to Cell stressors and their effect on expression · 12

Perlecan → CRE, ERK, FAK, Hypoxia, In, It, Mechanical, The, They, This, Under, When T84

related to Modification of glycosaminoglycan chains · 11

Perlecan → Although, By, Chinese Hamster Ovary, Chondroitin, Differential, GAG, Loss, Modifications, N-terminal, The, This

related to Diabetes and cardiovascular disease · 10

Perlecan → After, Although, Decreased, Diabetes, GAG, HS, It, One, Synthesis, The

related to Expression during development · 10

Perlecan → Again, Basement, C-terminus, Extracellular, Later, Pre-implantation, RT-PCR, The, This, Timing

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

expression cells protein cell development sulfate basement heparan gene endothelial chains matrix culture membrane human growth study extracellular mouse tissue

Perlecan relationships Subject–Predicate–Object triples

TTTA extracted 240 structured relationships around Perlecan. Examples in this analysis include Perlecan → Aliases → HSPG2, HSPG, PLC, PRCAN, SJA, SJS, SJS1, heparan sulfate proteoglycan 2 and Perlecan → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3SH4, 3SH5. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Perlecan	Aliases	HSPG2, HSPG, PLC, PRCAN, SJA, SJS, SJS1, heparan sulfate proteoglycan 2	1.00	infobox
Perlecan	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3SH4, 3SH5	1.00	infobox
Perlecan	Band	1p36.12	1.00	infobox
Perlecan	Band	4 D3\|4 69.93 cM	1.00	infobox
Perlecan	Bgee	saphenous vein	1.00	infobox
Perlecan	Bgee	popliteal artery	1.00	infobox
Perlecan	Bgee	tibial arteries	1.00	infobox
Perlecan	Bgee	thoracic aorta	1.00	infobox
Perlecan	Bgee	Descending thoracic aorta	1.00	infobox
Perlecan	Bgee	ascending aorta	1.00	infobox
Perlecan	Bgee	right coronary artery	1.00	infobox
Perlecan	Bgee	tibial nerve	1.00	infobox
Perlecan	Bgee	left coronary artery	1.00	infobox
Perlecan	Bgee	muscle layer of sigmoid colon	1.00	infobox
Perlecan	Bgee	right ventricle	1.00	infobox
Perlecan	Bgee	internal carotid artery	1.00	infobox
Perlecan	Bgee	external carotid artery	1.00	infobox
Perlecan	Bgee	lip	1.00	infobox
Perlecan	Bgee	ankle	1.00	infobox
Perlecan	Bgee	muscle of thigh	1.00	infobox
Perlecan	Bgee	molar	1.00	infobox
Perlecan	Bgee	genital tubercle	1.00	infobox
Perlecan	Bgee	tibiofemoral joint	1.00	infobox
Perlecan	BioGPS	More reference expression data	1.00	infobox
Perlecan	Chr.	Chromosome 1 (human)	1.00	infobox
Perlecan	Chr.	Chromosome 4 (mouse)	1.00	infobox
Perlecan	Databases	NCBI: entry; OMA: entry	1.00	infobox
Perlecan	End	21,937,310 bp	1.00	infobox
Perlecan	End	137,297,941 bp	1.00	infobox
Perlecan	Ensembl	ENSG00000142798	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Perlecan bring nearby vocabulary together. In this analysis, examples include Expression, Cells and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Perlecan
- Expression
- Cells
- Protein
- Cell
- Development
- Growth
- Sulfate
- Role
- Human
- Study
- Matrix
- Chains
perlecan
- Expression
- Cells
- Protein
- Cell
- Development
- Growth
- Sulfate
- Role
- Human
- Study
- Matrix
- Chains
heparan sulfate proteoglycan
- Sulfate
- Chains
- Domain
- Growth
- Loss
- Human
- Exon
- Perlecan
- Knockout
- Protein
- Culture
- Gene
protein
- Chains
- Domain
- Sulfate
- Cells
- Human
- Membrane
- Could
- Loss
- Shown
- Extracellular
- Matrix
- Expression
gene
- Mouse
- Signaling
- Development
- Knockout
- Human
- Exon
- Perlecan
- Expression
- Heparan
- Sulfate
- Mice
- Tissue
extracellular matrix
- Matrix
- Tissue
- Chains
- Membranes
- Cells
- Development
- Endothelial
- Expression
- Perlecan
- Human
- Could
- Protein
vascular endothelial
- Cells
- Growth
- Matrix
- Treatment
- Extracellular
- Human
- Perlecan
- Study
- Expression
- Effect
- Signaling
- Chains
smooth muscle cells
- Endothelial
- Perlecan
- Culture
- Human
- Expression
- Extracellular
- Matrix
- Protein
- Membranes
- Vitro
- Treatment
- Effect

Connections between topic areas Semantic bridges

For Perlecan, one of the stronger structural bridges in this analysis connects Perlecan with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Perlecan — Structure · splits 68 ⟂ 19

Perlecan — Overview · splits 69 ⟂ 18

Perlecan — Function · splits 72 ⟂ 15

Perlecan — Modification of glycosaminoglycan chains · splits 78 ⟂ 9

Perlecan — Degradation · splits 78 ⟂ 9

Perlecan — Disease association · splits 79 ⟂ 8

Perlecan — Interactions · splits 81 ⟂ 6

Map overview Semantic statistics

Perlecan

Nodes87

Edges86

Triples240

Avg. degree1.98

Density0.022989

Components1

Source & methodology

TTTA analyzes the structure around Perlecan to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Cultures, Structure & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Perlecan · EN edition · Analysis: TopicsToTalkAbout