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Perlecan

Perlecan (PLC) also known as basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) or heparan sulfate proteoglycan 2 (HSPG2), is a protein that in humans is encoded by the HSPG2 gene. The HSPG2 gene codes for a 4,391 amino acid protein with a molecular weight of 468,829. It is one of the largest known proteins. The name perlecan…

Cultures, Structure & Function

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Aliases
HSPG2, HSPG, PLC, PRCAN, SJA, SJS, SJS1, heparan sulfate proteoglycan 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3SH4, 3SH5
Band
1p36.12 · 4 D3|4 69.93 cM
Bgee
saphenous vein · popliteal artery · tibial arteries · thoracic aorta · Descending thoracic aorta
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 4 (mouse)

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Overview

Structure

Function

Modification of glycosaminoglycan chains

Degradation

Expression

Disease association

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

Perlecan

Nodes87
Edges86
Triples240
Avg. degree1.98
Density0.022989
Components1

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Perlecan

Top relations

Gene ontology · 35
Perlecan → amyloid-beta binding, angiogenesis, animal organ morphogenesis, basement membrane, brain development, calcium ion binding, cell differentiation, cell migration, collagen-containing extracellular matrix, extracellular exosome, extracellular matrix, extracellular matrix disassembly, extracellular matrix organization, extracellular matrix structural constituent conferring compression resistance, extracellular region, extracellular space, focal adhesion, glycosaminoglycan biosynthetic process, glycosaminoglycan catabolic process, glycosaminoglycan metabolic process
related to Structure · 20
Perlecan → Although HS, CS, DGSDE, Domain, Domain II, Domain III, Domain IV, HS, HS/CS, HSPG2, IG, IV, IVa, IVb, LDL, Removal, The, The C-terminal Domain, The N-terminal, Thus
Bgee · 19
Perlecan → ankle, ascending aorta, Descending thoracic aorta, external carotid artery, genital tubercle, internal carotid artery, left coronary artery, lip, molar, muscle layer of sigmoid colon, muscle of thigh, popliteal artery, right coronary artery, right ventricle, saphenous vein, thoracic aorta, tibial arteries, tibial nerve, tibiofemoral joint
RNA expression pattern · 19
Perlecan → ankle, ascending aorta, Descending thoracic aorta, external carotid artery, genital tubercle, internal carotid artery, left coronary artery, lip, molar, muscle layer of sigmoid colon, muscle of thigh, popliteal artery, right coronary artery, right ventricle, saphenous vein, thoracic aorta, tibial arteries, tibial nerve, tibiofemoral joint
related to Cancer · 18
Perlecan → By, Cancer, ECM, GAG, II, III, In, MeWo, MeWo/70W, More, One, RT101, Since, The, They, This, Thus, While Perlecan
related to Degradation · 13
Perlecan → Addition, Although Whitelock, Another, Cathepsin, Cells, ECM, FGF, FGF-10, FGF-positive, HS-bound, Specific, The, This
related to Cell stressors and their effect on expression · 12
Perlecan → CRE, ERK, FAK, Hypoxia, In, It, Mechanical, The, They, This, Under, When T84
related to Modification of glycosaminoglycan chains · 11
Perlecan → Although, By, Chinese Hamster Ovary, Chondroitin, Differential, GAG, Loss, Modifications, N-terminal, The, This
related to Diabetes and cardiovascular disease · 10
Perlecan → After, Although, Decreased, Diabetes, GAG, HS, It, One, Synthesis, The
related to Expression during development · 10
Perlecan → Again, Basement, C-terminus, Extracellular, Later, Pre-implantation, RT-PCR, The, This, Timing

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Important terminology

expression cells protein cell development sulfate basement heparan gene endothelial chains matrix culture membrane human growth study extracellular mouse tissue

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PerlecanAliasesHSPG2, HSPG, PLC, PRCAN, SJA, SJS, SJS1, heparan sulfate proteoglycan 21.00infobox
PerlecanAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3SH4, 3SH51.00infobox
PerlecanBand1p36.121.00infobox
PerlecanBand4 D3|4 69.93 cM1.00infobox
PerlecanBgeesaphenous vein1.00infobox
PerlecanBgeepopliteal artery1.00infobox
PerlecanBgeetibial arteries1.00infobox
PerlecanBgeethoracic aorta1.00infobox
PerlecanBgeeDescending thoracic aorta1.00infobox
PerlecanBgeeascending aorta1.00infobox
PerlecanBgeeright coronary artery1.00infobox
PerlecanBgeetibial nerve1.00infobox
PerlecanBgeeleft coronary artery1.00infobox
PerlecanBgeemuscle layer of sigmoid colon1.00infobox
PerlecanBgeeright ventricle1.00infobox
PerlecanBgeeinternal carotid artery1.00infobox
PerlecanBgeeexternal carotid artery1.00infobox
PerlecanBgeelip1.00infobox
PerlecanBgeeankle1.00infobox
PerlecanBgeemuscle of thigh1.00infobox
PerlecanBgeemolar1.00infobox
PerlecanBgeegenital tubercle1.00infobox
PerlecanBgeetibiofemoral joint1.00infobox
PerlecanBioGPSMore reference expression data1.00infobox
PerlecanChr.Chromosome 1 (human)1.00infobox
PerlecanChr.Chromosome 4 (mouse)1.00infobox
PerlecanDatabasesNCBI: entry; OMA: entry1.00infobox
PerlecanEnd21,937,310 bp1.00infobox
PerlecanEnd137,297,941 bp1.00infobox
PerlecanEnsemblENSG000001427981.00infobox

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