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Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the…
The analysis highlights Role in hedgehog signaling, Discovery and Role in disease as prominent areas in the source structure around Patched.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Patched shows recurring relationship patterns in the source. For example, Patched → Among, Hedgehog, In, Recent, Smoothened, When Another extracted example is Patched → Gorlin, Hereditary, Mice, Mutated, PTCH1. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
hedgehog signaling gene mutations smoothened protein receptor ptch1 cell pathway medulloblastoma role activity present ptc negative fly spatial part bound
TTTA extracted 23 structured relationships around Patched. Examples in this analysis include Patched → Alt. symbols → NBCCS, PTCH and Patched → Domains → InterPro. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Patched | Alt. symbols | NBCCS, PTCH | 1.00 | infobox |
| Patched | Domains | InterPro | 1.00 | infobox |
| Patched | HGNC | 9585 | 1.00 | infobox |
| Patched | Locus | Chr. 9 q22.1q31 | 1.00 | infobox |
| Patched | NCBI gene | 5727 | 1.00 | infobox |
| Patched | OMIM | 601309 | 1.00 | infobox |
| Patched | RefSeq | NM_000264 | 1.00 | infobox |
| Patched | Search for | Search forStructuresSwiss-modelDomainsInterPro | 1.00 | infobox |
| Patched | Structures | Swiss-model | 1.00 | infobox |
| Patched | Symbol | PTCH1 | 1.00 | infobox |
| Patched | UniProt | Q13635 | 1.00 | infobox |
| Patched | is a | essential gene in embryogenesis for proper segmentation in the fly embryo | 0.90 | text |
The concept neighborhoods around Patched bring nearby vocabulary together. In this analysis, examples include Hedgehog, Activity and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Patched, one of the stronger structural bridges in this analysis connects Patched with Role in hedgehog signaling. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Patched to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Role in hedgehog signaling, Discovery & Role in disease, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Patched · EN edition · Analysis: TopicsToTalkAbout