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Patched

Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the…

Role in hedgehog signaling, Discovery & Role in disease

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Key facts & relationships

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Alt. symbols
NBCCS, PTCH
Domains
InterPro
HGNC
9585
Locus
Chr. 9 q22.1q31
NCBI gene
5727
OMIM
601309

Topics to explore

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Overview

Discovery

Role in hedgehog signaling

Role in disease

Advanced semantic analysis

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Map overview Semantic statistics

Patched

Nodes29
Edges28
Triples23
Avg. degree1.93
Density0.068966
Components1

How this topic connects Entity context

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Patched

Top relations

related to Role in hedgehog signaling · 6
Patched → Among, Hedgehog, In, Recent, Smoothened, When
related to Role in disease · 5
Patched → Gorlin, Hereditary, Mice, Mutated, PTCH1
Alt. symbols · 1
Patched → NBCCS, PTCH
Domains · 1
Patched → InterPro
HGNC · 1
Patched → 9585
Locus · 1
Patched → Chr. 9 q22.1q31
NCBI gene · 1
Patched → 5727
OMIM · 1
Patched → 601309
RefSeq · 1
Patched → NM_000264
Search for · 1
Patched → Search forStructuresSwiss-modelDomainsInterPro

Important terminology Word statistics

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Important terminology

hedgehog signaling gene mutations smoothened protein receptor ptch1 cell pathway medulloblastoma role activity present ptc negative fly spatial part bound

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PatchedAlt. symbolsNBCCS, PTCH1.00infobox
PatchedDomainsInterPro1.00infobox
PatchedHGNC95851.00infobox
PatchedLocusChr. 9 q22.1q311.00infobox
PatchedNCBI gene57271.00infobox
PatchedOMIM6013091.00infobox
PatchedRefSeqNM_0002641.00infobox
PatchedSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
PatchedStructuresSwiss-model1.00infobox
PatchedSymbolPTCH11.00infobox
PatchedUniProtQ136351.00infobox
Patchedis aessential gene in embryogenesis for proper segmentation in the fly embryo0.90text

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    Min side: 3
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