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Patched: Role in hedgehog signaling, Discovery & Role in disease

Patched (Ptc) is a conserved 12-pass transmembrane protein receptor that plays an obligate negative regulatory role in the Hedgehog signaling pathway in insects and vertebrates. Patched is an essential gene in embryogenesis for proper segmentation in the fly embryo, mutations in which may be embryonic lethal. Patched functions as the receptor for the…

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Patched topic overview

The analysis highlights Role in hedgehog signaling, Discovery and Role in disease as prominent areas in the source structure around Patched.

Related topics
24
Source areas
4
Connected nodes
28
Extracted relationships
23
Concept neighborhoods
17
Bridge connections
28

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Role in hedgehog signaling · 7 topics
Discovery · 6 topics
Role in disease · 6 topics
Overview · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Alt. symbols
NBCCS, PTCH
Domains
InterPro
HGNC
9585
Locus
Chr. 9 q22.1q31
NCBI gene
5727
OMIM
601309

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Role in hedgehog signaling

Role in disease

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Patched connects Entity context

The extracted context around Patched shows recurring relationship patterns in the source. For example, Patched → Among, Hedgehog, In, Recent, Smoothened, When Another extracted example is Patched → Gorlin, Hereditary, Mice, Mutated, PTCH1. Use these groups to spot repeated connection types before inspecting the individual relationships.

Patched

Top relations

related to Role in hedgehog signaling · 6
Patched → Among, Hedgehog, In, Recent, Smoothened, When
related to Role in disease · 5
Patched → Gorlin, Hereditary, Mice, Mutated, PTCH1
Alt. symbols · 1
Patched → NBCCS, PTCH
Domains · 1
Patched → InterPro
HGNC · 1
Patched → 9585
Locus · 1
Patched → Chr. 9 q22.1q31
NCBI gene · 1
Patched → 5727
OMIM · 1
Patched → 601309
RefSeq · 1
Patched → NM_000264
Search for · 1
Patched → Search forStructuresSwiss-modelDomainsInterPro

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

hedgehog signaling gene mutations smoothened protein receptor ptch1 cell pathway medulloblastoma role activity present ptc negative fly spatial part bound

Patched relationships Subject–Predicate–Object triples

TTTA extracted 23 structured relationships around Patched. Examples in this analysis include Patched → Alt. symbols → NBCCS, PTCH and Patched → Domains → InterPro. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PatchedAlt. symbolsNBCCS, PTCH1.00infobox
PatchedDomainsInterPro1.00infobox
PatchedHGNC95851.00infobox
PatchedLocusChr. 9 q22.1q311.00infobox
PatchedNCBI gene57271.00infobox
PatchedOMIM6013091.00infobox
PatchedRefSeqNM_0002641.00infobox
PatchedSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
PatchedStructuresSwiss-model1.00infobox
PatchedSymbolPTCH11.00infobox
PatchedUniProtQ136351.00infobox
Patchedis aessential gene in embryogenesis for proper segmentation in the fly embryo0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Patched bring nearby vocabulary together. In this analysis, examples include Hedgehog, Activity and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Patched
    • Hedgehog
    • Activity
    • Protein
    • Signaling
    • Basal
    • Carcinoma
    • Including
    • Negative
    • Part
    • Spatial
    • Medulloblastoma
    • Pathway
  • patched
    • Hedgehog
    • Activity
    • Protein
    • Signaling
    • Basal
    • Carcinoma
    • Including
    • Negative
    • Part
    • Spatial
    • Medulloblastoma
    • Pathway
  • hedgehog signaling pathway
    • Signaling
    • Patched
    • Smoothened
    • Plays
    • Regulatory
    • Transmembrane
    • Vertebrates
    • Activity
    • Pathway
    • Present
    • Protein
    • Receptor
  • role in hedgehog signaling
    • Signaling
    • Transmembrane
    • Vertebrates
    • Patched
    • Smoothened
    • Chr
    • Activity
    • Pathway
    • Present
    • Protein
    • Receptor
    • Ptch1
  • negative feedback
    • Insects
    • Obligate
    • Plays
    • Regulatory
    • Transmembrane
    • Vertebrates
    • Part
    • Ptc
    • Role
    • Signaling
    • Spatial
    • Activity
  • conserved
    • 12-pass
    • Insects
    • Obligate
    • Plays
    • Regulatory
    • Transmembrane
    • Vertebrates
    • Negative
    • Ptc
    • Role
    • Pathway
    • Protein
  • cell membrane
    • Present
    • Basal
    • Carcinoma
    • Cell
    • Including
    • Membrane
    • Smoothened
    • Medulloblastoma
    • Pathway
    • Receptor
    • Patched
    • Hedgehog
  • basal cell carcinoma
    • Carcinoma
    • Including
    • Medulloblastoma
    • Basal
    • Cell
    • Membrane
    • Present
    • Smoothened
    • Ptch1
    • Patched
    • Mutations
    • Hedgehog

Connections between topic areas Semantic bridges

For Patched, one of the stronger structural bridges in this analysis connects Patched with Role in hedgehog signaling. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PatchedRole in hedgehog signaling · splits 21 ⟂ 8
PatchedDiscovery · splits 22 ⟂ 7
PatchedRole in disease · splits 22 ⟂ 7
PatchedOverview · splits 23 ⟂ 6

Map overview Semantic statistics

Patched

Nodes29
Edges28
Triples23
Avg. degree1.93
Density0.068966
Components1

Source & methodology

TTTA analyzes the structure around Patched to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Role in hedgehog signaling, Discovery & Role in disease, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Patched · EN edition · Analysis: TopicsToTalkAbout

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