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5′-nucleotidase (5′-NT), also known as ecto-5′-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that in humans is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine.
The analysis highlights Clinical significance, Function and Overview as prominent areas in the source structure around NT5E.
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Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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The extracted context around NT5E shows recurring relationship patterns in the source. For example, NT5E → 5'-nucleotidase activity, adenosine biosynthetic process, AMP catabolic process, anchored component of membrane, cell surface, cytosol, dephosphorylation, DNA metabolic process, extracellular exosome, hydrolase activity, hydrolase activity, acting on ester bonds, leukocyte cell-cell adhesion, membrane, metal ion binding, NAD metabolic process, negative regulation of inflammatory response, nucleoplasm, nucleotide binding, nucleotide catabolic process, plasma membrane Another extracted example is NT5E → Achilles tendon, canal of the cervix, cartilage tissue, epithelium of stomach, germinal epithelium, granulocyte, jejunal mucosa, left colon, lumbar spinal ganglion, neural layer of retina, proximal tubule, retinal pigment epithelium, right kidney, seminal vesicula, skin of external ear, smooth muscle tissue, stromal cell of endometrium, synovial joint, tendon of biceps brachii, tibia. Use these groups to spot repeated connection types before inspecting the individual relationships.
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adenosine cd73 immune cells also enzyme human cancer bp gene expression chr band tumor function binding response chromosome external mouse
TTTA extracted 139 structured relationships around NT5E. Examples in this analysis include NT5E → 3.1.3.35 → ↗ and NT5E → Aliases → NT5E, CALJA, CD73, E5NT, NT, NT5, NTE, eN, eNT, 5'-nucleotidase ecto. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| NT5E | 3.1.3.35 | ↗ | 1.00 | infobox |
| NT5E | 3.1.3.5 | ↗ | 1.00 | infobox |
| NT5E | 3.1.3.89 | ↗ | 1.00 | infobox |
| NT5E | 3.1.3.91 | ↗ | 1.00 | infobox |
| NT5E | 3.1.3.99 | ↗ | 1.00 | infobox |
| NT5E | Aliases | NT5E, CALJA, CD73, E5NT, NT, NT5, NTE, eN, eNT, 5'-nucleotidase ecto | 1.00 | infobox |
| NT5E | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4H2B, 4H1Y, 4H2F, 4H2I, 4H1S, 4H2G | 1.00 | infobox |
| NT5E | Band | 6q14.3 | 1.00 | infobox |
| NT5E | Band | 9|9 E3.1 | 1.00 | infobox |
| NT5E | Bgee | stromal cell of endometrium | 1.00 | infobox |
| NT5E | Bgee | Achilles tendon | 1.00 | infobox |
| NT5E | Bgee | jejunal mucosa | 1.00 | infobox |
| NT5E | Bgee | synovial joint | 1.00 | infobox |
| NT5E | Bgee | cartilage tissue | 1.00 | infobox |
| NT5E | Bgee | smooth muscle tissue | 1.00 | infobox |
| NT5E | Bgee | canal of the cervix | 1.00 | infobox |
| NT5E | Bgee | tendon of biceps brachii | 1.00 | infobox |
| NT5E | Bgee | germinal epithelium | 1.00 | infobox |
| NT5E | Bgee | tibia | 1.00 | infobox |
| NT5E | Bgee | epithelium of stomach | 1.00 | infobox |
| NT5E | Bgee | lumbar spinal ganglion | 1.00 | infobox |
| NT5E | Bgee | left colon | 1.00 | infobox |
| NT5E | Bgee | right kidney | 1.00 | infobox |
| NT5E | Bgee | seminal vesicula | 1.00 | infobox |
| NT5E | Bgee | granulocyte | 1.00 | infobox |
| NT5E | Bgee | neural layer of retina | 1.00 | infobox |
| NT5E | Bgee | retinal pigment epithelium | 1.00 | infobox |
| NT5E | Bgee | proximal tubule | 1.00 | infobox |
| NT5E | Bgee | skin of external ear | 1.00 | infobox |
| NT5E | BioGPS | More reference expression data | 1.00 | infobox |
The concept neighborhoods around NT5E bring nearby vocabulary together. In this analysis, examples include Response, Tumor and Cellular. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For NT5E, one of the stronger structural bridges in this analysis connects NT5E with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around NT5E to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — NT5E · EN edition · Analysis: TopicsToTalkAbout
