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NT5E

5′-nucleotidase (5′-NT), also known as ecto-5′-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that in humans is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine.

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3.1.3.35
3.1.3.5
3.1.3.89
3.1.3.91
3.1.3.99
Aliases
NT5E, CALJA, CD73, E5NT, NT, NT5, NTE, eN, eNT, 5'-nucleotidase ecto

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Map overview Semantic statistics

NT5E

Nodes56
Edges55
Triples160
Avg. degree1.96
Density0.035714
Components1

How this topic connects Entity context

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NT5E

Top relations

related to Cancer · 23
NT5E → A1, A2A, A3, Adenosine, CD3, CD73, DC, DCs, Due, Enzyme, Especially, Free, Gαi, His, In, It, MDSC, NK, Subsequently, This
Gene ontology · 22
NT5E → 5'-nucleotidase activity, adenosine biosynthetic process, AMP catabolic process, anchored component of membrane, cell surface, cytosol, dephosphorylation, DNA metabolic process, extracellular exosome, hydrolase activity, hydrolase activity, acting on ester bonds, leukocyte cell-cell adhesion, membrane, metal ion binding, NAD metabolic process, negative regulation of inflammatory response, nucleoplasm, nucleotide binding, nucleotide catabolic process, plasma membrane
Bgee · 20
NT5E → Achilles tendon, canal of the cervix, cartilage tissue, epithelium of stomach, germinal epithelium, granulocyte, jejunal mucosa, left colon, lumbar spinal ganglion, neural layer of retina, proximal tubule, retinal pigment epithelium, right kidney, seminal vesicula, skin of external ear, smooth muscle tissue, stromal cell of endometrium, synovial joint, tendon of biceps brachii, tibia
RNA expression pattern · 20
NT5E → Achilles tendon, canal of the cervix, cartilage tissue, epithelium of stomach, germinal epithelium, granulocyte, jejunal mucosa, left colon, lumbar spinal ganglion, neural layer of retina, proximal tubule, retinal pigment epithelium, right kidney, seminal vesicula, skin of external ear, smooth muscle tissue, stromal cell of endometrium, synovial joint, tendon of biceps brachii, tibia
related to External links · 11
NT5E → Medicine, Medicine Medical Subject Headings, MeSH, National Library, Overview, P21589, PDB, PDBe-KB, This, UniProt, United States National Library
related to Immunosuppression · 9
NT5E → ADP, Also, ATP, CD4, CD73, Immune, They, This, Tregs
related to Anti-tumor immune response · 6
NT5E → For, In, MicroRNAs, RNA, This, Upon
related to Transcription factor binding sites · 6
NT5E → AMP, AP-2, Because, SMAD, SMADs, SP-1
Band · 2
NT5E → 6q14.3, 9|9 E3.1
Chr. · 2
NT5E → Chromosome 6 (human), Chromosome 9 (mouse)

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Important terminology

adenosine cd73 immune cells also enzyme human cancer bp gene expression chr band tumor function binding response chromosome external mouse

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
NT5E3.1.3.351.00infobox
NT5E3.1.3.51.00infobox
NT5E3.1.3.891.00infobox
NT5E3.1.3.911.00infobox
NT5E3.1.3.991.00infobox
NT5EAliasesNT5E, CALJA, CD73, E5NT, NT, NT5, NTE, eN, eNT, 5'-nucleotidase ecto1.00infobox
NT5EAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4H2B, 4H1Y, 4H2F, 4H2I, 4H1S, 4H2G1.00infobox
NT5EBand6q14.31.00infobox
NT5EBand9|9 E3.11.00infobox
NT5EBgeestromal cell of endometrium1.00infobox
NT5EBgeeAchilles tendon1.00infobox
NT5EBgeejejunal mucosa1.00infobox
NT5EBgeesynovial joint1.00infobox
NT5EBgeecartilage tissue1.00infobox
NT5EBgeesmooth muscle tissue1.00infobox
NT5EBgeecanal of the cervix1.00infobox
NT5EBgeetendon of biceps brachii1.00infobox
NT5EBgeegerminal epithelium1.00infobox
NT5EBgeetibia1.00infobox
NT5EBgeeepithelium of stomach1.00infobox
NT5EBgeelumbar spinal ganglion1.00infobox
NT5EBgeeleft colon1.00infobox
NT5EBgeeright kidney1.00infobox
NT5EBgeeseminal vesicula1.00infobox
NT5EBgeegranulocyte1.00infobox
NT5EBgeeneural layer of retina1.00infobox
NT5EBgeeretinal pigment epithelium1.00infobox
NT5EBgeeproximal tubule1.00infobox
NT5EBgeeskin of external ear1.00infobox
NT5EBioGPSMore reference expression data1.00infobox

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